Central Corneal Endothelial Cell Density and Central Corneal Thickness in Ocular Hypertension and Primary Open-Angle Glaucoma

Korey, Michael; Gieser, David K.; Kass, Michael A.; Waltman, Stephen R.; Gordon, Mae E.; Becker, Bernard

doi:10.1016/0002-9394(82)90005-8

Cited by 80 publications

(53 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, several studies reported that increased IOP has little effect on the corneal endothelium. 9,10 Taken together, our results showing that the history of trabeculectomy had little effect on graft survival in spite of poor post-operative IOP control are not surprising.…”

Section: Discussionmentioning

confidence: 54%

Penetrating keratoplasty for bullous keratopathy after trabeculectomy

Fukuoka

Honda

Usui

et al. 2008

Eye

View full text Add to dashboard Cite

Purpose To evaluate the results of penetrating keratoplasty (PK) in eyes with bullous keratopathy having previously undergone trabeculectomy. Methods We reviewed medical records of patients that had undergone PK for bullous keratopathy having previously undergone trabeculectomy. A total of 34 eyes in 34 patients were included in the study. As a control group, we reviewed the medical records of 26 eyes in 26 patients that had no history of glaucoma and who had undergone PK for bullous keratopathy in the same period at the same institutes. Kaplan-Meier survival analysis was performed to estimate the cumulative probability of successful intraocular pressure (IOP) control, immune reaction-free graft, and graft survival. Results Visual acuity improved by more than two lines in 30-34 eyes (88%). Log-rank tests showed a statistically significant difference in the cumulative probability of successful IOP control between eyes with functioning blebs and eyes with non-functioning blebs (P ¼ 0.0005), but not between the experimental subjects of 34 eyes and the control group (P ¼ 0.198). The log-rank test did not show statistically significant differences in the cumulative probability of immune reactionfree grafts and graft failure between the subjects and the control group and between eyes with functioning blebs and eyes with non-functioning blebs. Conclusion The outcomes for PK in bullous keratopathy are good for patients having previously undergone trabeculectomy. Surgical procedures should be performed before PK in eyes with non-functioning blebs even when IOP is controllable with medication.

show abstract

Section: Discussionmentioning

confidence: 54%

Penetrating keratoplasty for bullous keratopathy after trabeculectomy

Fukuoka

Honda

Usui

et al. 2008

Eye

View full text Add to dashboard Cite

show abstract

“…Data from one study suggest a lower ECD in patients with glaucoma than in those without glaucoma, however, with no significant differences for pleomorphism and polymegathism (Gagnon et al 1997). Ocular hypertension and primary open-angle glaucoma had no adverse effect on ECD in another study (Korey et al 1982). Some authors have reported a more pronounced endothelial cell deterioration in eyes with both PES and glaucoma than in eyes with only glaucoma (Inoue et al 2002;Wali et al 2009).…”

Section: Discussionmentioning

confidence: 90%

Corneal endothelial cells 6–7 years following cataract surgery in patients with pseudoexfoliation syndrome

Østern

Drolsum

2010

Acta Ophthalmologica

View full text Add to dashboard Cite

Abstract.Purpose: To assess the condition of the corneal endothelium an extended period after cataract surgery in eyes with and without pseudoexfoliation syndrome (PES).Methods: Forty‐six patients with PES who underwent cataract surgery in the Eye Department, Oslo University Hospital, in 2001 and 2002 were enrolled and compared to 101 matched controls without PES who had surgery in the same period. They were re‐examined 6–7 years following surgery with measurements taken of corneal endothelial cell density (ECD), pleomorphism, polymegathism and corneal thickness.Results: Mean ECD was 2024 ± 371 cells/mm2 in eyes with PES and 2144 ± 365 cells/mm2 in eyes without PES. The difference was not statistically significant. No significant difference in polymegathism and pleomorphism was noted. Mean corneal thickness was 543 and 547 μm in eyes with and without PES, respectively (not statistically significant). The presence of glaucoma in pseudoexfoliative eyes was not associated with endothelial cell changes.Conclusion: Six to 7 years following cataract surgery, no statistically significant differences were established in ECD, pleomorphism, polymegathism and corneal thickness in eyes with and without PES. No clinical signs of corneal decompensation were noted amongst the participants.

show abstract

“…34 Similar to the observations of previous reports, we identified no significant difference in CCT based on gender in this study. [35][36][37] The relationship between CCT and age has been extensively studiedFalthough the majority of authors report a gradual decrease in CCT with advancing age after infancy, [38][39][40][41][42] in contrast, others have reported no change or an increase in CCT with advancing age. 36,43 The relationship between significant endothelial dysfunction and increased corneal thickness is well established, 3,[44][45][46] and recognized causes of increased corneal thickness include anterior segment disease and previous intraocular surgery.…”

Section: Discussionmentioning

confidence: 99%

Identifying relationships between tomography-derived corneal thickness, curvature, and diameter and in vivo confocal microscopic assessment of the endothelium in healthy corneas of young adults

Patel

McGhee

2008

Eye

View full text Add to dashboard Cite

Purpose Despite the importance of a healthy endothelial layer in anterior segment surgery, the possible influence of corneal parameters on endothelial cell density (ECD) has largely been ignored in the young adult eye. This study investigated the possible associations between corneal tomographic parameters and ECD values in young adults. Methods Subjects aged 21-30 years, with normal corneas were recruited. Mean ECD, mean cell area (MCA), coefficient of variation for cell area (COVA), and proportion of hexagonal cells were derived by in vivo confocal microscopy. The Orbscan II system was used to measure corneal parameters including: thickness, horizontal corneal diameter, corneal curvature, anterior and posterior elevation, and eccentricity. Results Sixty-two subjects (42 female, 20 male) were included (mean age 25±3 years). Overall mean ECD was 3169±309 cells/mm 2 with no differences between genders. Mean percentage of hexagonality was 53 ± 5%, male subjects (55%) had a higher percentage of hexagonal cells than female subjects (51%) (P ¼ 0.02). Central corneal thickness (CCT) was 529±43 lm. Central ECD was significantly correlated with CCT (Pearson's r ¼ 0.26, P ¼ 0.04). However, horizontal corneal diameter (r ¼ 0.19, P ¼ 0.14), anterior corneal curvature (r ¼ À0.07, P ¼ 0.6), and posterior corneal curvature (r ¼ À0.07, P ¼ 0.6) were not correlated with ECD or percentage of hexagonality. There was no statistically significant association between anterior chamber depth (3.6±0.3 mm) and ECD (r ¼ 0.15, P ¼ 0.3). Conclusion Corneal thickness is related to ECD in normal young adult eye, with lower ECD values identified in thinner corneas; however, corneal diameter and corneal curvature do not have a significant correlation with ECD.

show abstract

Central Corneal Endothelial Cell Density and Central Corneal Thickness in Ocular Hypertension and Primary Open-Angle Glaucoma

Cited by 80 publications

References 19 publications

Penetrating keratoplasty for bullous keratopathy after trabeculectomy

Penetrating keratoplasty for bullous keratopathy after trabeculectomy

Corneal endothelial cells 6–7 years following cataract surgery in patients with pseudoexfoliation syndrome

Identifying relationships between tomography-derived corneal thickness, curvature, and diameter and in vivo confocal microscopic assessment of the endothelium in healthy corneas of young adults

Contact Info

Product

Resources

About