Central circuits mediating patterned autonomic activity during active vs. passive emotional coping

Bandler, Richard; Keay, Kevin A.; Floyd, Nicole S.; Price, Joseph L.

doi:10.1016/s0361-9230(00)00313-0

Cited by 518 publications

(457 citation statements)

References 63 publications

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“…Human DBS and animal studies have identified that dlPAG activation triggers active coping strategies, involving sympathoexcitation, hyperventilation and short‐duration, non‐opioid‐mediated analgesia [Bandler et al, 2000; Green et al, 2005; Keay and Bandler, 2001; Pereira et al, 2010]. Our results are consistent with these observations.…”

Section: Discussionsupporting

confidence: 91%

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Connectivity‐based segmentation of the periaqueductal gray matter in human with brainstem optimized diffusion MRI

Ezra

Faull

Jbabdi

et al. 2015

Human Brain Mapping

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The periaqueductal gray matter (PAG) is a midbrain structure, involved in key homeostatic neurobiological functions, such as pain modulation and cardiorespiratory control. Animal research has identified four subdivisional columns that differ in both connectivity and function. Until now these findings have not been replicated in humans. This study used high‐resolution brainstem optimized diffusion magnetic resonance imaging and probabilistic tractography to segment the human PAG into four subdivisions, based on voxel connectivity profiles. We identified four distinct subdivisions demonstrating high spatial concordance with the columns of the animal model. The resolution of these subdivisions for individual subjects permitted detailed examination of their structural connectivity without the requirement of an a priori starting location. Interestingly patterns of forebrain connectivity appear to be different to those found in nonhuman studies, whereas midbrain and hindbrain connectivity appears to be maintained. Although there are similarities in the columnar structure of the PAG subdivisions between humans and nonhuman animals, there appears to be different patterns of cortical connectivity. This suggests that the functional organization of the PAG may be different between species, and as a consequence, functional studies in nonhumans may not be directly translatable to humans. This highlights the need for focused functional studies in humans. Hum Brain Mapp 36:3459–3471, 2015. © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 91%

“…Animal studies have identified a rostral‐cephalic somatotrophic organization of inputs into the individual segments of the PAG, this may explain the pattern of segmentation observed. [Bandler et al, 2000; Keay and Bandler, 2001, 2002; Parry et al, 2008]. …”

Section: Discussionmentioning

confidence: 99%

Connectivity‐based segmentation of the periaqueductal gray matter in human with brainstem optimized diffusion MRI

Ezra

Faull

Jbabdi

et al. 2015

Human Brain Mapping

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“…Functional neuroimaging studies in humans indicate that PAG activation by nociceptive inputs is modulated by attention, emotion, expectation of pain and expectation-related placebo analgesia [54][55][56][57][58][59][60][61]. Experimental studies using chemical microstimulation indicate that the different columns of the PAG organize different coping strategies to pain and other stressors [62][63][64][65][66]. The lateral and dorsolateral PAG initiate flight or fight responses associated with tachycardia, hypertension, and redistribution of blood flow, i.e., sympathoexcitatory responses mediated by neurons of the ventrolateral medulla (VLM), which activate sympathetic preganglionic neurons controlling cardiovascular effectors [65][66][67][68].…”

Section: Descending Pain Modulatory Systemmentioning

confidence: 99%

“…Experimental studies using chemical microstimulation indicate that the different columns of the PAG organize different coping strategies to pain and other stressors [62][63][64][65][66]. The lateral and dorsolateral PAG initiate flight or fight responses associated with tachycardia, hypertension, and redistribution of blood flow, i.e., sympathoexcitatory responses mediated by neurons of the ventrolateral medulla (VLM), which activate sympathetic preganglionic neurons controlling cardiovascular effectors [65][66][67][68]. In contrast, neurons of the ventrolateral PAG column initiate sympathoinhibitory responses (hypotension and bradycardia) that are associated with immobility and hyporeactivity to the environment.…”

Section: Descending Pain Modulatory Systemmentioning

confidence: 99%

Nociception and autonomic nervous system

et al. 2013

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The International Association for the Study of Pain (IASP) defines pain as ''an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage''. Pain may also be experienced in absence of noxious stimuli and together with temperature and other bodily feelings constitute the interoception redefined as the sense of the physiological condition of the entire body, not just the viscera. The main characteristic of these feelings is the affective aspect. Emotion, motivation, and consequent behavior connected with these feelings characterize their homeostatic role. This implies an interaction between neural structures involved in pain sensation and autonomic control. The aim of this review is to focus on pain perception, mainly on pain matrix structures' connections with the autonomic nervous system.

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“…Its autonomic effects have been well studied in animals [92,[114][115][116][117] and changes noted with DBS [101]. We have demonstrated a positive correlation between the degree of analgesia in patients receiving PAG DBS and the magnitude of blood pressure reduction [118], and have shown that whereas dorsal PAG stimulation can acutely elevate blood pressure, ventral stimulation reduces it [119,120].…”

Section: Physiologymentioning

confidence: 72%

Neuropathic Pain and Deep Brain Stimulation

Pereira

Aziz

2014

Neurotherapeutics

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Deep brain stimulation (DBS) is a neurosurgical intervention the efficacy, safety, and utility of which are established in the treatment of Parkinson's disease. For the treatment of chronic, neuropathic pain refractory to medical therapies, many prospective case series have been reported, but few have published findings from patients treated with current standards of neuroimaging and stimulator technology over the last decade . We summarize the history, science, selection, assessment, surgery, programming, and personal clinical experience of DBS of the ventral posterior thalamus, periventricular/periaqueductal gray matter, and latterly rostral anterior cingulate cortex (Cg24) in 113 patients treated at 2 centers (John Radcliffe, Oxford, UK, and Hospital de São João, Porto, Portugal) over 13 years. Several experienced centers continue DBS for chronic pain, with success in selected patients, in particular those with pain after amputation, brachial plexus injury, stroke, and cephalalgias including anesthesia dolorosa. Other successes include pain after multiple sclerosis and spine injury. Somatotopic coverage during awake surgery is important in our technique, with cingulate DBS under general anesthesia considered for whole or hemibody pain, or after unsuccessful DBS of other targets. Findings discussed from neuroimaging modalities, invasive neurophysiological insights from local field potential recording, and autonomic assessments may translate into improved patient selection and enhanced efficacy, encouraging larger clinical trials.

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Central circuits mediating patterned autonomic activity during active vs. passive emotional coping

Cited by 518 publications

References 63 publications

Connectivity‐based segmentation of the periaqueductal gray matter in human with brainstem optimized diffusion MRI

Connectivity‐based segmentation of the periaqueductal gray matter in human with brainstem optimized diffusion MRI

Nociception and autonomic nervous system

Neuropathic Pain and Deep Brain Stimulation

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