Central blood pressure, arterial stiffness and the heart in hypertensive patients

Kohara, Katsuhiko

doi:10.1038/hr.2009.171

Cited by 8 publications

(9 citation statements)

References 16 publications

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“…The relationship between smoking cessation and arterial wall thickness and stiffness has been reported by van den Berkmortel et al8 CBP can now be measured noninvasively, and CBP measurement using such methods has yielded many new findings. It is well known that elevation in CBP, rather than elevation in brachial blood pressure, is more closely associated with the onset of cardiovascular events 9. The impact of smoking cessation with nicotine replacement on arterial stiffness remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Effects of smoking cessation on central blood pressure and arterial stiffness

Takami¹,

Saito²

2011

VHRM

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Purpose:Smoking affects arterial stiffness, thus causing an elevation in central blood pressure (CBP). The present study was designed to examine whether smoking cessation treatment improved CBP and arterial stiffness.Patients and methods:We conducted an observational study of 70 patients receiving smoking cessation treatment. Before and 60 weeks after the start of a 12-week varenicline treatment, we measured brachial blood pressure, CBP, brachial-ankle pulse wave velocity (baPWV), normalized radial augmentation index (rAIx@75), left ventricular weight, and left ventricular diastolic function of each patient. The data were compared between the patients who succeeded in quitting smoking (smoking cessation group; n = 37) and those who failed to quit smoking (smoking group; n = 33).Results:Baseline characteristics were similar in both groups. Brachial blood pressure remained unchanged in both groups. CBP, baPWV, and rAIx@75 decreased significantly in the smoking cessation group, while these parameters showed no significant change in the smoking group. Thus, CBP, baPWV, and rAIx@75 showed greater decrease in the smoking cessation group than in the smoking group (CBP, −7.1 ± 1.4 mmHg vs 1.2 ± 2.7 mmHg; P < 0.01; baPWV, −204 ± 64 cm/s vs −43 ± 72 cm/s; P < 0.01; rAIx@75, −6.4 ± 2.8% vs −1.0 ± 3.9%; P < 0.01). Left ventricular weight and left ventricular diastolic function remained unchanged in both groups.Conclusion:Patients in the smoking cessation group showed significant improvement in CBP, baPWV, and rAIx@75. These results indicate that smoking cessation can improve arterial stiffness and CBP.

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Section: Introductionmentioning

confidence: 99%

Effects of smoking cessation on central blood pressure and arterial stiffness

Takami¹,

Saito²

2011

VHRM

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“…В исследовании PROOF была доказана четкая связь между увеличением артериальной жесткости и развитием гипертрофии ЛЖ [12]. Также показана связь между миокардиальным и сосудистым фиброзом, лежащим в основе повышения артериальной жесткости [13]. В нашей работе у пациентов всех групп с АГ ИММЛЖ был значимо выше, чем у лиц из КГ.…”

Section: Discussionunclassified

Arterial Stiffness Parameters and Subendocardial Viability Ratio in Patients with Arterial Hypertension Affected by Subclinical and Clinical Atherosclerosis

Гумерова

Gomonova

Sayganov

2022

Racionalʹnaâ farmakoterapiâ v kardiologii

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Aim. Assessment the arteries' stiffness parameters and subendocardial viability ratio in hypertensive patients with various degrees of severity of the atherosclerotic process manifestation.Material and methods. 133 hypertensive patients were divided into 3 groups, similar in age and sex, depending on the severity of the atherosclerotic process: hypertensive patients without atherosclerosis (n=42; 53.3±7.6 years); patients with hypertension and subclinical atherosclerosis (SА) (n=52; 56.5±8.0 years); patients with hypertension and coronary artery disease (CAD) (n=39; 57.4±6.8years) and control group which consisted of individuals without cardiovascular diseases (n=33; 54.6±8.4 years). All participants underwent 24-hour blood pressure monitoring with assessment of arterial stiffness parameters and subendocardial viability ratio (SERV).Results. Subjects from all groups with hypertension have significantly higher mean systolic blood pressure (SBP) (131.1±11.9, 127.8±14.8, 128.6±15.3 respectively; p<0.001), as well as central systolic blood pressure (SBPao) (122.0±11.0, 118.8±12.7, 119.9±13.3 respectively; p<0.001), pulse pressure (PP) (46.4±9.8, 45.6±10.6, 48.9±12.0 respectively; p<0.05) and central pulse pressure (PPao) (35.5±8.5, 34.9±8.5, 38.5±9.6 respectively; p<0.05), pulse wave velocity in aorta (PWVao) (11.3±1.5, 12.3±1.8, 11.5±1.7 respectively; p<0.05) compared with control group (SBP 116.3±7.3; SBPao 108.9±6.4, PP 39.9±6.5, PPao 30.9±5.4, PWVao 10.4±1.3). In hypertensive patients with SA, PWVao was significantly higher compared to other groups (p<0.05). With bringing the indicator to SBP 100 mmHg and HR=60 beats/min, there were no differences between the control group and the group with hypertension (p=0.3), also groups with hypertension+SA and hypertension+CAD did not significantly differ from each other (p=0.6). SERV in subjects with hypertension+SA was significantly lower than in patients with hypertension (p<0.05) and no significant differences were detected with the group with hypertension+CAD (p=0.77).Conclusions. In hypertensive patients with SA, a decrease in subendocardial perfusion is associated with an increase in pulse wave velocity in aorta. Moreover, such a decrease in perfusion approaches to the values of patients suffering from coronary artery disease, which indicates significant changes in the small vessels of the heart that form the coronary reserve.

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“… 17 , 18 , 19 When central BP is combined with measurements of arterial stiffness, we can generate a full picture of how cardiovascular hemodynamics respond to BFR with RE. 20 , 21 , 22 …”

Section: Introductionmentioning

confidence: 99%