Central and peripheral sites of action for the protective effect of opioids of the rat stomach

Ferri, Sergio Solbes; Arrigo-Reina, R.; Candeletti, Sanzio; Costa, Giuliano; Murari, G; Speroni, Ester; Scoto, G.M.

doi:10.1016/s0031-6989(83)80050-2

Cited by 40 publications

(11 citation statements)

References 15 publications

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“…The protective effect we described for opioids on gastric damage in rats induced by exposure to cold and restraint [1][2][3] is also seen against lesions provoked in the rat stomach by ulcerating agents, NaOH and HC1 solutions, for doses up to 20 mg/kg of morphine and 2 mg/kg of DAMME. The finding appeared to be related to an involve ment of specific opiate receptors, since nal trexone, a blocker of these receptors -prefer entially those of the p type -prevented the action of 10 mg of morphine and 1 mg of DAMME.…”

Section: Discussionmentioning

confidence: 96%

“…The importance of prostaglandins is already underlined by the fact that in rats they pre vent [ 13] gastric necrosis elicited by a variety of damaging agents such as absolute ethanol, boiling water and strong chemicals. It has also been shown that administration of opioids to rats results in an increase of pros taglandin production in some organs, includ ing the stomach [2,14]. An analogous hy pothesis of prostaglandin mediation was sug gested for other peptides, such as neuroten sin, whose protective effects on the gastric mucosa in stressed rats were clearly antago nized by indomethacin [15], Additional mechanisms, however, must be considered for opioid effects on gastric lesions in different experimental conditions.…”

Section: Discussionmentioning

confidence: 96%

“…We recently reported that both morphine and the synthetic opioid [D-Ala2, MePhe4, Met(0)5ol] enkephalin (DAMME) have a protective effect against gastric damage in the rat exposed to cold and restraint [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

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Protection by Opioids against Gastric Lesions Caused by Necrotizing Agents

Ferri

Speroni²,

Candeletti³

et al. 1988

Pharmacology

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The synthetic opioid met-enkephalin analog [D-Ala², MePhe⁴, Met(0)⁵ol] enkephalin (DAMME) and the opiate morphine injected intraperitoneally to rats at doses of 0.5–2 and 5–20 mg/kg, respectively, showed a protective effect on gastric damage induced by oral administration of necrotizing agents (0.6 NHCl or 0.2 NNaOH solutions, 1 ml/rat). The protection was prevented by naltrexone (10 mg/kg s.c), an opioid antagonist with long-lasting activity. Histological sections of mucosal samples from animals pretreated with morphine (10 mg/kg i.p.) and DAMME (1 mg/kg i.p.) showed less alteration of the columnar epithelium, with a normal glandular structure, than untreated rats. A mediation of prostaglandins is suggested, since indomethacin (10 mg/kg s.c.) significantly reduced the protective effects of opioids.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 96%

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Protection by Opioids against Gastric Lesions Caused by Necrotizing Agents

Ferri

Speroni²,

Candeletti³

et al. 1988

Pharmacology

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“…Pathological effects of stress are suppressed by endogenous opioids released into bloodstream during stress (24). Intracerebroventricular and intraperitoneal (ip) injections of the opioid peptides reduced the gastric acid secretion, ip injections at the same time increased the production of prostaglandin in the gastric mucosa (25). Studies have shown that suckling during the post-partum period is associated with decreased HPA axis activity (26) and that lactating rats demonstrate blunted adrenocorticotropic hormone (ACTH) and cortisol secretion to various forms of stressors (27).…”

Section: Neuroendocrine Response Of the Body To Stress Factorsmentioning

confidence: 99%

Role of acupuncture in stress management

Cabıoğlu¹

2012

mpj

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Stress factors impair physiological and psychological balance state of the individuals. This situation can cause various diseases. Today, diseases caused by stress are treated with methods like educational program for coping with stress, psychotherapy, drug therapy. Recently, acupuncture treatment is added to these methods. Acupuncture treatment effects to modulate various neurophysiologic mechanisms in during resistance period of stress. This mechanism provides support for the person's psychological state. Acupuncture treatment increases the secretion of hormones such as endomorphine, beta endorphine, enkephalin, serotonin and cortisol from central nervous system. Stress factors increase endomorphin, beta endorphin, enkephalin, serotonin and oxytocin levels in the central nervous system and plasma in the resistance period to stress. Acupuncture applications increase the synthesis and release of endomorphin, beta endorphin, enkephalin, serotonin and oxytocin from the central nervous system which strengthens the individual's resistance period to cope with stress. Therefore, method of acupuncture is also used in the treatment of diseases caused by stress.

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“…Opioid receptors known to influence gas tric functions are present both in the central nervous system (CNS) [1,2] and in the gastric wall [3], so either one or both sites might mediate opioid's protective effect in gastric damage induced by stress [4], In previous studies we reported that intracerebroventricu lar (i.c.v.) or intraperitoneal (i.p.)…”

Section: Introductionmentioning

confidence: 99%

Central and Peripheral Involvement of Endogenous Opioid Peptides in Gastric Protection in Stressed Rats

Scoto

Parenti²

1996

Pharmacology

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The effects of intraperitoneal and intracerebroventricular administration of the inhibitor of endopeptidase EC 24.11 (enkephalinase), thiorphan, and the synthetic enkephalin analogue [D-Ala²-Met⁵]enkephalinamide (DALA) were investigated in cold-restraint-stressed rats. Drugs were administered alone or after pretreatment with naloxone or naloxone methiodide given 20 min prior to the drugs. Thiorphan and DALA, administered centrally (4 µg i.c.v./rat) or peripherally (400 µg/kg), induced a significant gastric protection. Prior treatment with naloxone s.c. (1 mg/kg) inhibited the effect induced by i.e.v. or i.p. injections of thiorphan or DALA. In contrast, s.c. administration of naloxone methiodide (1 mg/ kg) did not affect the response induced by central administration of thiorphan or DALA, but was able to prevent that of thiorphan or DALA when they were administered i.p. These data strongly support the hypothesis of a central and peripheral involvement of endogenous opioid peptides in gastric protection in stressed rats.

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Central and peripheral sites of action for the protective effect of opioids of the rat stomach

Cited by 40 publications

References 15 publications

Protection by Opioids against Gastric Lesions Caused by Necrotizing Agents

Protection by Opioids against Gastric Lesions Caused by Necrotizing Agents

Role of acupuncture in stress management

Central and Peripheral Involvement of Endogenous Opioid Peptides in Gastric Protection in Stressed Rats

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