Central and peripheral pain intervention by Ophiorrhiza rugosa leaves: Potential underlying mechanisms and insight into the role of pain modulators

Chy, Md. Nazim Uddin; Adnan, Md.; Chowdhury, Md. Riad; Pagano, Ester; Kamal, A.T.M. Mostafa; Oh, Ki‐Kwang; Cho, Dong Ha; Capasso, Raffaele

doi:10.1016/j.jep.2021.114182

Cited by 68 publications

(23 citation statements)

References 56 publications

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“…acute and chronic inflammations. In this test, protein denaturation can occur due to the disruption of various electrostatic, hydrogen, hydrophobic, and disulfide bonds and heat-denatured proteins have been found to be more effective than all-natural proteins for the inducement of delayed hypersensitivity [20,21]. Furthermore, it has been established that conventional NSAIDs such as phenylbutazone and indomethazine act not only by inhibiting the development of endogenous prostaglandins by inhibiting the COX enzyme but also by preventing protein denaturation [22].…”

Section: Discussionmentioning

confidence: 99%

Chemical Profiling, Pharmacological Insights and In Silico Studies of Methanol Seed Extract of Sterculia foetida

Alam

Banu

Aziz

et al. 2021

Plants

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Sterculia foetida, also known as jangli badam in Bangladesh, is a traditionally used plant that has pharmacological activities. A qualitative phytochemical analysis was performed to assess the metabolites in a methanolic extract of S. foetida seeds (MESF), and the cytotoxic, thrombolytic, anti-arthritics, analgesic, and antipyretic activities were examined using in vitro, in vivo, and in silico experiments. Quantitative studies were performed through gas chromatography-mass spectroscopy (GC-MS) analysis. The brine shrimp lethality bioassays and clot lysis were performed to investigate the cytotoxic and thrombolytic activities, respectively. The anti-arthritics activity was assessed using the albumin denaturation assay. Analgesic activity was determined using the acetic acid-induced writhing test and the formalin-induced paw-licking test. A molecular docking study was performed, and an online tool was used to perform ADME/T (absorption, distribution, metabolism, and excretion/toxicity) and PASS (Prediction of Activity Spectra for Substances). GC-MS analysis identified 29 compounds in MESF, consisting primarily of phenols, terpenoids, esters, and other organic compounds. MESF showed moderate cytotoxic activity against brine shrimp and significant thrombolytic and anti-arthritics activities compared with the relative standards. The extract also showed a dose-dependent and significant analgesic and antipyretic activities. Docking studies showed that 1-azuleneethanol, acetate returned the best scores for the tested enzymes. These findings suggested that MESF represents a potent source of thrombolytic, anti-arthritic, analgesic, antipyretic agents with moderate cytotoxic effects.

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Section: Discussionmentioning

confidence: 99%

Chemical Profiling, Pharmacological Insights and In Silico Studies of Methanol Seed Extract of Sterculia foetida

Alam

Banu

Aziz

et al. 2021

Plants

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“…Medicinal plants have long been used for treating deadly diseases like cancer, diabetes and heart diseases because of the presence of bioactive phytochemical constituents [ 1 ]. They also have healing effects against allergic syndrome, inflammation, oxidative damage, free radical and DNA (deoxyribonucleic acid) damage [ [2] , [3] , [4] ]. Phytotherapy has less intense side effects than conventional synthetic drugs; and could be used as an alternative source of therapies.…”

Section: Introductionmentioning

confidence: 99%

A flavone from the ethyl acetate extract of Leea rubra leaves with DNA damage protection and antineoplastic activity

Das

Parvin

Hasan

et al. 2022

Biochemistry and Biophysics Reports

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“…Previous studies have suggested that medicinal herbs and plants have strong potential values for improving human health and preventing and treating diseases, such as inhibiting tumor growth [ 9 , 10 ], relieving central and peripheral pain [ 11 ], antidepression [ 12 ], and preventing and treating neurological disorders [ 13 ], gastrointestinal diseases [ 14 ], viral infections, and even COVID-19 [ 15 ]. Astragalus membranaceus Bunge is a commonly used Chinese medicinal herb and also used as food material with a history of more than 2000 years.…”

Section: Introductionmentioning

confidence: 99%

Effects of Astragalus Polysaccharides on CD8+ Tissue-Resident Memory T Cells in Mice with Herpes Simplex

Shi

Zhang

Liu

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. This study aimed to explore whether astragalus polysaccharides (APS) could treat herpes simplex by increasing tissue-resident memory CD8+ T cells (CD8+ TRM cells) and analyze its potential mechanism using the network pharmacologic approach. Methods. C57BL/6J male mice aged 6–8 weeks were divided into a model group with HSV-1 infection treated by saline, a control group without HSV-1 infection but treated by saline, and an APS group with HSV-1 infection treated by APS. Clinical signs were observed, and the disease score was recorded every day. The skin lesions on day 9 after infection were taken for flow cytometric analysis to evaluate CD8+ TRM cells. Network pharmacologic analysis was performed to select the potential protein targets of astragalus associated with herpes simplex. Besides, Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed. The peripheral blood from the retroorbital venous plexus was collected to evaluate the levels of serum interferon-γ (IFN-γ) and interleukin 12 (IL-12). The comparisons of clinical signs, the disease score, CD8+ TRM cells, the serum IFN-γ, and IL-12 levels were performed among the three groups. Results. Compared with the model group, the disease score in the APS group was significantly lower ( p < 0.05 ). On the day 9 after HSV-1 infection, there was no significant difference in the body weight of mice among the three groups. However, compared with the control group or model group, the spleen weight in the APS group increased significantly ( p < 0.05 ). The surface antigens of CD8+ TRM cells had no significant difference between the control group and the model group, while compared with the model group, the surface antigens of CD8 ( p < 0.05 ), CD69 ( p < 0.05 ), and CD103 ( p < 0.05 ) in the APS group increased significantly. Moreover, the serum IL-12 ( p < 0.05 ) and IFN-γ ( p < 0.01 ) levels in the APS group increased significantly compared with the model group. Conclusion. Our study suggested that APS could alleviate the symptoms of the mice infected with HSV-1, and CD8+ TRM cells in the skin lesions and the levels of IL-12 and IFN-γ in the serum of mice with HSV-1 infection increased after the APS treatment, of which the specific underlying mechanism requires further experiments to clarify. In addition, the antiviral effect of APS might be worthy of further development and utilization.

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Central and peripheral pain intervention by Ophiorrhiza rugosa leaves: Potential underlying mechanisms and insight into the role of pain modulators

Cited by 68 publications

References 56 publications

Chemical Profiling, Pharmacological Insights and In Silico Studies of Methanol Seed Extract of Sterculia foetida

Chemical Profiling, Pharmacological Insights and In Silico Studies of Methanol Seed Extract of Sterculia foetida

A flavone from the ethyl acetate extract of Leea rubra leaves with DNA damage protection and antineoplastic activity

Effects of Astragalus Polysaccharides on CD8+ Tissue-Resident Memory T Cells in Mice with Herpes Simplex

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