Central and Peripheral Arteriovenous Passage Times of the Retina in Glaucoma

Duijm, H.F.A.; Berg, Thomas; Greve, E. L.

doi:10.1006/exer.1999.0683

Cited by 6 publications

(5 citation statements)

References 14 publications

(24 reference statements)

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“…Corrosion cast preparations of the choroidal vasculature For corrosion cast preparations, three DBA mice of each of six age groups (2,4,6,9,12 and over 20 months old) and three C57 mice of each of three age groups (2, 6 and 20 months old) were used. The procedure of araldite injection and tissue digestion in mice was performed as described previously [21,24].…”

Section: Methodsmentioning

confidence: 99%

“…For NADPH-d-staining of choroidal and retinal whole mounts, the eyes of 18 DBA mice (2,4,6,9,12 and over 20 months old) and ten C57 mice (2, 6 and over 20 months of age) were used. The eyes were fixed for 4 h in 4% paraformaldehyde and rinsed in phosphate buffered saline (PBS, pH 7.2-7.4).…”

Section: Enzyme Histochemistrymentioning

confidence: 99%

“…The important role of primary vascular changes leading to glaucomatous pathology has been emphasized primarily for low tension glaucoma where intraocular pressure (IOP), one of the major risk factors for glaucoma, is not elevated [4,28]. Previous reports, however, also pointed to haemodynamic and vascular changes in primary open angle glaucoma and in various secondary glaucomas [9,18,30].…”

Section: Introductionmentioning

confidence: 96%

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Vascular changes in the posterior eye segment of secondary angle-closure glaucoma: cause or consequence?

May

Mittag

2006

Graefe's Arch Clin Exp Ophthalmo

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Section: Methodsmentioning

confidence: 99%

Section: Enzyme Histochemistrymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Vascular changes in the posterior eye segment of secondary angle-closure glaucoma: cause or consequence?

May

Mittag

2006

Graefe's Arch Clin Exp Ophthalmo

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“…In the most severely affected POAG eyes, despite the IOP reduction induced by appropriate medical or surgical treatments, the fall in the autoregulation mechanisms makes IOP decrease unable to improve OPP. The underlying tools causing this effect are at present unknown [22]. …”

Section: Discussionmentioning

confidence: 99%

Ocular Perfusion Pressure and Visual Field Indice Modifications Induced by α-Agonist Compound (Clonidine 0.125%, Apraclonidine 1.0% and Brimonidine 0.2%) Topical Administration

et al. 2003

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Objective: The aim of this study was to verify the acute effects of α-adrenoreceptor agonist eyedrop administration on visual field parameters and ocular perfusion pressure (OPP) in patients affected by primary open-angle glaucoma. Methods: A prospective, randomized double-blind study was carried out. Sixty-four glaucomatous subjects were enrolled in the clinical trial and subsequently separated into four study groups, of 16 patients each, to compare the systemic and ocular effects of placebo, clonidine 0.125%, apraclonidine 1.0% and brimonidine 0.2%. Results: No significant variations in the ocular or systemic parameters were observed after placebo administration. All the α-adrenoreceptor agonist compounds induced a significant reduction of the intraocular pressure. Clonidine induced significant modifications of mean blood pressure, OPP and visual field indices. The acute administration of apraclonidine did not affect both mean blood pressure and OPP, but a worsening of the visual field was nevertheless recorded. The analyzed parameters did not significantly vary after brimonidine instillation. Conclusions: The present findings demonstrate that the lack of effects on the blood flow and the absence of vasomotor activity at the level of the posterior pole exhibited by brimonidine is related to its α-2 selectivity, as appears by comparing this compound with the other α-agonists available for the management of glaucoma.

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“…The significant associations of low ocular perfusion pressure 12 and other vascular changes in low-tension and hightension glaucoma [1][2][3][4][5][6][7][8][9][10][11][12]23 prompted the question of whether retinal blood flow could predict the progression to OAG prior to the development of increased optic disc cupping. Therefore, we applied a measure of the pressure effects of retinal arterioles in different eyes.…”

Section: Commentmentioning

confidence: 99%

Using the Arteriolar Pressure Attenuation Index to Predict Ocular Hypertension Progression to Open-angle Glaucoma

Cohen

Lee²,

Herndon³

et al. 2003

Arch Ophthalmol

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Background: Vascular phenomena are considered important to optic nerve and visual field progression in open-angle glaucoma(OAG).Arecentlydescribedformulation,thePressure Attenuation Index (PAI), links arteriolar caliber variations to pressure loss along the retinal arteriolar system. Objective: To examine whether the PAI could predict ocular hypertension (OHT) progression to OAG. Methods: The PAI was calculated for 27 eyes of 14 patients with OHT using initial and final digitized optic disc photographs taken during a follow-up interval of 5 to 18 years. Serial stereo color disc photographs and visual fields were analyzed to determine progression. Results: At baseline, the arteriolar tree of 8 subjects with OHT that progressed to OAG (n=8 eyes) demonstrated a 45.8% greater mean PAI value than that of 7 subjects who did not progress (n=7 eyes) (mean±SEM, 5.31±0.93 vs 3.64±0.34; r=0.83). Progression was independent of baseline cup-disc ratio. The PAI values of subjects with stable OHT remained stable after a median follow-up interval of 12.0 years. The PAI values of subjects with OHT that progressed demonstrated a further increase of 19.97%±11.24% during a median follow-up period of 6.0 years. Conclusions: The results support the hypothesis that low end-arteriolar pressure predicts the progression from OHT to OAG. The PAI provides a new, early, reproducible, and physiological method to study vascular phenomena in glaucoma.

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Central and Peripheral Arteriovenous Passage Times of the Retina in Glaucoma

Cited by 6 publications

References 14 publications

Vascular changes in the posterior eye segment of secondary angle-closure glaucoma: cause or consequence?

Vascular changes in the posterior eye segment of secondary angle-closure glaucoma: cause or consequence?

Ocular Perfusion Pressure and Visual Field Indice Modifications Induced by α-Agonist Compound (Clonidine 0.125%, Apraclonidine 1.0% and Brimonidine 0.2%) Topical Administration

Using the Arteriolar Pressure Attenuation Index to Predict Ocular Hypertension Progression to Open-angle Glaucoma

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