Central and Peripheral Actions of Adenosine and Its Analogues on Intestinal Myoelectric Activity and Propulsion in Rats

Fargeas, M. J.; Fioramonti, Jean; Buéno, Lionel

doi:10.1111/j.1365-2982.1990.tb00018.x

Cited by 7 publications

References 26 publications

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Adenosine and pain relief: A clinical overview

Segerdahl¹,

Sollevi²

1998

Drug Dev. Res.

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This overview summarizes the current clinical state of knowledge in the field of adenosine‐mediated pain reduction, also including a condensed experimental background of relevance for clinical implementation. Clinical investigations have been systematically performed and include experimental pain models in volunteers, as well as studies in acute perioperative pain and in chronic neuropathic pain. Adenosine has been administered as a low‐dose intravenous infusion and as an intrathecal injection. Effects on pain and on signs of hyperexcitability in the nervous system have been investigated, both after administration of adenosine alone and in combination with well‐known analgesic agents. The different modes of adenosine administration demonstrate reduced pain, primarily in modalities that involve mechanisms of hyperexcitability of the central nervous system, i.e., central sensitization. Because this phenomenon is an important factor in chronic pain conditions, the promising results of pain relief in patients with neuropathic pain suggest that this is especially relevant for future development and research. In addition, the potential use of adenosine in combination with other pain‐modulating agents deserves further evaluation. Drug Dev. Res. 45:151–158, 1998. © 1998 Wiley‐Liss, Inc.

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Adenosine and pain relief: A clinical overview

Segerdahl¹,

Sollevi²

1998

Drug Dev. Res.

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Roles of Purines in Nociception and Pain

Salter¹,

Sollevi²

2001

Purinergic and Pyrimidinergic Signalling I

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Differences between jejunal myoelectric activity after a meal and during phase 2 of migrating motor complexes in healthy humans

et al. 1992

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Using an intraluminal probe with six pairs of annular electrodes, the myoelectric activity of the proximal jejunum was recorded during 48-hr sessions in 16 healthy volunteers receiving evening and noon meals (1000 kcal) and breakfast (400 kcal). In 10 subjects receiving no drug, the characteristics of the migrating motor complexes (period, duration of each phase, velocity of propagation of phase 3, duration of the postprandial disruption) varied markedly between subjects but were relatively constant from the first to the second day of recording. Single spike bursts propagated at a rate of 2-5 cm/sec, clusters of 3-10 spike bursts propagated at a rate of 0.5-1 cm/sec, and similar clusters recurring repetitively each 1.5-2 min were observed after the meals and very rarely in the fasted state during phase 2 of nocturnal migrating motor complexes. In six subjects, oral administration of codeine (50 mg) 1 hr before a meal induced migrating motor complexes in the postprandial state, with characteristics similar to that observed in the fasted state except a longer duration of phase 2. Single spike bursts and isolated and repetitive clusters of spike bursts were observed during phase 2 of the codeine-induced migrating motor complexes and after meals preceded by placebo, but very rarely during the phase 2 of nocturnal (fasted state) migrating motor complexes. It is concluded that the patterns of jejunal contractions consisting of propagated single spike bursts and isolated or repetitive spike bursts characterize the postprandial state in healthy humans and are dependent upon digesta flow.

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Central and Peripheral Actions of Adenosine and Its Analogues on Intestinal Myoelectric Activity and Propulsion in Rats

Cited by 7 publications

References 26 publications

Adenosine and pain relief: A clinical overview

Adenosine and pain relief: A clinical overview

Roles of Purines in Nociception and Pain

Differences between jejunal myoelectric activity after a meal and during phase 2 of migrating motor complexes in healthy humans

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