Central and cardiac stress resilience consistently linked to integrated immuno‐neuroendocrine responses across stress models in male mice

Helman, Tessa; Headrick, John P.; Peart, Jason Nigel John; Stapelberg, Nicolas J. C.

doi:10.1111/ejn.15747

Cited by 3 publications

(1 citation statement)

References 130 publications

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“…However, no studies have yet discovered a correlation between ST2related SNPs and depression. An experimental study was conducted on male mice to investigate the role of IL-33 in the brain (47). The findings suggest that chronic unpredictable mild stress (CUMS) and social stress (SS) may lead to anxiety or depression-like behavior, whereas restraint stress (RS) appears to reduce depression-like behavior.…”

Section: Discussionmentioning

confidence: 99%

The role of IL-33 in depression: a systematic review and meta-analysis

Liu,

Ren

et al. 2023

Front. Psychiatry

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Depression has long been considered a disease involving immune hyperactivation. The impact of pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6, and IL-8 on depression has been widely studied. However, the effect of IL-33, another pro-inflammatory cytokine, has been less researched. Currently, research on the correlation between IL-33 and depression risk is inconsistent. In response to these divergent results, we conducted a review and meta-analysis aimed at resolving published research on the correlation between IL-33 and depression risk, and understanding the potential role of IL-33 in the development and treatment of depression. After searching different databases, we analyzed 8 studies. Our meta-analysis showed that IL-33 had a positive correlation with reduced risk of depression. The pooled standard mean differences (SMD) = 0.14, 95% confidence interval (CI): 0.05–0.24. Subgroup analysis results showed that IL-33 and ST2 levels in cerebrospinal fluid and serum is positive correlated with reduced risk of major depressive disorder (MDD) and bipolar disorder (BD). According to the characteristics of the included literature, the results mainly focuses on Caucasian. Furthermore, according to the subgroup analysis of depression-related data sources for disease or treatment, the correlation between IL-33 and depression risk is reflected throughout the entire process of depression development and treatment. Therefore, the change of IL-33 level in serum and cerebrospinal fluid can serve as useful indicators for assessing the risk of depression, and the biomarker provides potential treatment strategies for reducing the burden of the disease.

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Section: Discussionmentioning

confidence: 99%

The role of IL-33 in depression: a systematic review and meta-analysis

Liu,

Ren

et al. 2023

Front. Psychiatry

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The sex-dependent response to psychosocial stress and ischaemic heart disease

Helman

Headrick

Stapelberg

et al. 2023

Front. Cardiovasc. Med.

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Stress is an important risk factor for modern chronic diseases, with distinct influences in males and females. The sex specificity of the mammalian stress response contributes to the sex-dependent development and impacts of coronary artery disease (CAD). Compared to men, women appear to have greater susceptibility to chronic forms of psychosocial stress, extending beyond an increased incidence of mood disorders to include a 2- to 4-fold higher risk of stress-dependent myocardial infarction in women, and up to 10-fold higher risk of Takotsubo syndrome—a stress-dependent coronary-myocardial disorder most prevalent in post-menopausal women. Sex differences arise at all levels of the stress response: from initial perception of stress to behavioural, cognitive, and affective responses and longer-term disease outcomes. These fundamental differences involve interactions between chromosomal and gonadal determinants, (mal)adaptive epigenetic modulation across the lifespan (particularly in early life), and the extrinsic influences of socio-cultural, economic, and environmental factors. Pre-clinical investigations of biological mechanisms support distinct early life programming and a heightened corticolimbic-noradrenaline-neuroinflammatory reactivity in females vs. males, among implicated determinants of the chronic stress response. Unravelling the intrinsic molecular, cellular and systems biological basis of these differences, and their interactions with external lifestyle/socio-cultural determinants, can guide preventative and therapeutic strategies to better target coronary heart disease in a tailored sex-specific manner.

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The Relationship between Psychological Stress and Anthropometric, Biological Outcomes: A Systematic Review

Rog,

Nowak,

Wingralek

2024

Medicina

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Background and Objectives: Challenges and threats to global security and the growing demands of today’s society lead to significantly increased exposure to stress. Stress can negatively affect numerous physiological processes, including metabolic changes. An unhealthy lifestyle might intensify this disruption. The aim of the systematic review was to establish the effect of psychological stress on metabolic and anthropometric factors in healthy individuals. Materials and Methods: The study was conducted according to the PRISMA guidelines; and the risk of bias (ROB) assessment was based on the Newcastle–Ottawa Scale (NOS). A literature search of the MEDLINE/PubMed database was conducted using specific search terms. Results: We identified 32 articles meeting the inclusion criteria for the review with the different experimental designs and aims. Most of the papers were at high ROB. The included studies were conducted in groups of adults and children/teenagers. The most-often-applied tool to measure stress severity was the Perceived Stress Scale (PSS). Twenty-two studies analyzed the connection between stress and body composition, and bioimpedance analysis (BIA) was the most often used method. For biological parameters, the most frequently analyzed was cortisol (n = 9). The other examined factors included glucose, insulin, parameters related to food intake regulation, carbohydrates, lipid metabolism, inflammation, and oxidative stress. The included studies were incompliance in relation to the assessment method and type of assessed biological fluids. Conclusions: The vast majority of studies do not support the effect of chronic distress on anthropometric measurements and biological markers levels. However, many of them suggest adverse, synergistic effects of unhealthy lifestyle patterns and the stress on the examined variables. Further experiments should implement a similar and repeatable methodology.

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Central and cardiac stress resilience consistently linked to integrated immuno‐neuroendocrine responses across stress models in male mice

Cited by 3 publications

References 130 publications

The role of IL-33 in depression: a systematic review and meta-analysis

The role of IL-33 in depression: a systematic review and meta-analysis

The sex-dependent response to psychosocial stress and ischaemic heart disease

The Relationship between Psychological Stress and Anthropometric, Biological Outcomes: A Systematic Review

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