Central amygdala circuits modulate food consumption through a positive valence mechanism

Douglass, Amelia M.; Kucukdereli, Hakan; Ponserre, Marion; Marković, Milica; Gründemann, Jan; Strobel, Cornelia; Morales, Pilar L Alcala; Conzelmann, Karl‐Klaus; Lüthi, Andreas; Klein, Rüdiger

doi:10.1101/145375

Cited by 17 publications

(42 citation statements)

References 57 publications

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“…The PBN has a well-described role in appetite suppression (Carter et al, 2013). Indeed, recent work describing a CeA to PBN projection indicates that GABAergic input from the CeA can promote food consumption (Douglass et al, 2017). Suppression of PBN anorexigenic neuronal ensembles could explain the increase in palatable fluid consumption observed in the previous experiments.…”

Section: Stimulation Of the Nts Ceapbn Projection Fails To Impact Comentioning

confidence: 86%

“…Previous work exploring the Htr2a CeAPBN projection in consumption showed that optogenetic stimulation of this pathway increased the duration of feeding bouts (Douglass et al, 2017). We thus examined whether the number and/or duration of drinking bouts were affected with stimulation of the NTS CeAPBN pathway.…”

Section: Stimulation Of the Nts Ceapbn Projection Promotes Consumptimentioning

confidence: 98%

“…The central nucleus of the amygdala (CeA) is a heterogeneous structure that plays an important role in the regulation of appetitive, aversive, and ethanol-mediated behaviors (Mahler and Berridge, 2009;Tye et al, 2011;Robinson et al, 2014;McCall et al, 2015;Warlow et al, 2017;Kim et al, 2017;Douglass et al, 2017;Hardaway et al, 2019;Salling et al, 2016). While some data have shed light on neuronal subpopulations influencing fear-and feeding-related behaviors in the CeA (Haubensak et al, 2010;Cai et al, 2014;Douglass et al, 2017), it remains unclear which CeA subpopulations and efferents influence ethanol consumption, particularly during early ethanol seeking (Gilpin et al, 2015;de Guglielmo et al, 2019). A promising CeA subpopulation that may regulate ethanol behaviors are the neurons that express the 13 amino-acid neuropeptide neurotensin (NTS).…”

Section: Introductionmentioning

confidence: 99%

“…An additional subpopulation of PBN neurons, the calcitonin gene-related peptide (CGRP) neurons, are part of an important circuit implicated in suppressing both food and fluid intake (Carter et al, 2013;Ryan et al, 2017). An Htr2a CeA-to-PBN (serotonin receptor 2a, Htr2a CeAPBN ) projection promotes feeding, suggesting the possibility of a CeA-to-PBN projection that promotes drinking (Douglass et al, 2017). A number of systems have been suggested as a link between food and ethanol consumption such as neuropeptide-Y (NPY; Kelley et al, 2001;Gilpin et al, 2004) and ghrelin (Leggio, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Manipulations of central amygdala neurotensin neurons alter the consumption of ethanol and sweet fluids in mice

Torruella-Suárez

Vandenberg

Cogan

et al. 2018

Preprint

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The central nucleus of the amygdala plays a significant role in alcohol use and other affective disorders; however, the genetically-defined neuronal subtypes and their projections that govern these behaviors are not well known. Here we show that neurotensin neurons in the central nucleus of the amygdala of male mice are activated by in vivo ethanol consumption and that genetic ablation of these neurons decreases ethanol consumption and preference in non-ethanol dependent animals. This ablation did not impact preference for sucrose, saccharin, or quinine. We found that the most robust projection of the central amygdala neurotensin neurons was to the parabrachial nucleus, a brain region known to be important in feeding behaviors, conditioned taste aversion, and alarm. Optogenetic stimulation of projections from these neurons to the parabrachial nucleus is reinforcing, and increases ethanol drinking as well as consumption of sucrose and saccharin solutions. These data suggest that this central amygdala to parabrachial nucleus projection influences the expression of reward-related phenotypes and is a novel circuit promoting consumption of ethanol and palatable fluids.

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Section: Stimulation Of the Nts Ceapbn Projection Fails To Impact Comentioning

confidence: 86%

Section: Stimulation Of the Nts Ceapbn Projection Promotes Consumptimentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Manipulations of central amygdala neurotensin neurons alter the consumption of ethanol and sweet fluids in mice

Torruella-Suárez

Vandenberg

Cogan

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…This striking difference in behaviour between shock‐resistant and shock‐sensitive animals could not be accounted for by any obvious differences in neuroanatomical placement, although a more refined study of these differences using a larger sample is needed to exclude this possibility. In addition, further study using cell‐type‐specific targeting of the CeA would help understand these effects, as recent studies have shown a role for different neuronal cell types in food seeking (Cai, Haubensak, Anthony, & Anderson, ; Douglass et al., ; Seo et al., ).…”

Section: Discussionmentioning

confidence: 99%

Optogenetic activation of the central amygdala generates addiction‐like preference for reward

Tom

Ahuja

Maniates

et al. 2018

Eur J of Neuroscience

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Drug and behavioural addictions are characterized by an intense and focused pursuit of a single reward above all others. Pursuit of the addictive reward is often compulsively sought despite adverse consequences and better alternative outcomes. Here, we explored the ability of the central amygdala (CeA) to powerfully bias choice, causing specific rewards to be almost compulsively preferred. Rats were trained on an operant choice task in which they could choose to respond on either of the two levers to receive a sucrose reward, one of which was paired with optogenetic stimulation of the CeA using channelrhodopsin-2 (ChR2). Rats developed an almost exclusive preference for the laser-paired reward over the otherwise equal unpaired reward. We found that this preference for stimulation-paired reward persists even when a much larger sucrose reward is offered as an alternative (contingency management) or when this preferred reward is paired with adverse consequences such as progressively larger electric foot shock, time delays or effort requirements. We also report that when challenged with foot shock, a small proportion of these animals (≈20%) retained an exclusive laser-paired reward preference, whereas others began to seek the alternate reward when the shock reached high levels. Lastly, we confirmed that optogenetic CeA stimulation was not independently rewarding if delivered in the absence of a paired sucrose reward. These results suggest a role for the CeA in focusing motivation and desire to excessive levels, generating addiction-like behaviour that persists in the face of more rewarding alternatives and adverse consequences.

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Activation patterns in male and female forebrain circuitries during food consumption under novelty

Greiner,

Witt,

Moran

et al. 2024

Brain Struct Funct

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Central amygdala circuits modulate food consumption through a positive valence mechanism

Cited by 17 publications

References 57 publications

Manipulations of central amygdala neurotensin neurons alter the consumption of ethanol and sweet fluids in mice

Manipulations of central amygdala neurotensin neurons alter the consumption of ethanol and sweet fluids in mice

Optogenetic activation of the central amygdala generates addiction‐like preference for reward

Activation patterns in male and female forebrain circuitries during food consumption under novelty

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