Central administration of zinc increases renal sodium and potassium excretion in rats

Castro-e-Silva, Emilio De; Luz, Carla Patrícia Novais; Marinho, C.A.; Castro, L.; Sarmento, C; Gonzalez, V.; Oliveira, Pedro Dantas; Nascimento, Thais; Santana, Pedro Augusto de; Lima, A.K.S.; Fregoneze, J.B.

doi:10.1016/s0006-8993(99)01930-7

Brain Research

1999

DOI: 10.1016/s0006-8993(99)01930-7

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Central administration of zinc increases renal sodium and potassium excretion in rats

Emilio De Castro-e-Silva

Carla Patrícia Novais Luz

C.A. Marinho

et al.

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“…The authors attributed these skin lesions to a depletion of Zn ions caused by the presence of excess ligands in the commercial formulations of nonionic linear GBCAs (16, 17). Indeed, increased excretion of Zn after administration of linear GBCAs has been described in several experimental setups and species, including humans (18–20).…”

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confidence: 99%

Evaluating the role of zinc in the occurrence of fibrosis of the skin: A preclinical study

Pietsch

Pering

Lengsfeld

et al. 2009

Magnetic Resonance Imaging

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Purpose:To investigate the possible role of Zn as a trigger for NSF we were using a previously established preclinical model. The depletion of endogenous Zinc ions (Zn) caused by the administration of gadolinium-based contrast agents (GBCAs) has been suggested as a possible pathomechanism for nephrogenic systemic fibrosis (NSF). Materials and Methods:In the Zn supplementation study, rats were injected with Gadodiamide, Omniscan, and Magnevist with or without Zn supplementation. In the Zn depletion study, animals were kept on a Zn-deficient diet or a special control diet and received injections of Omniscan, OptiMARK, Magnevist, Gadovist, and Gd-EDTA. Gd, Zn, and Cu concentrations in tissue were measured and histology of the skin was performed.Results: As seen in earlier studies, a difference in Gd concentration in the skin was observed following treatment with the different GBCAs. High Gd concentration in the skin correlated with the occurrence of NSF-like skin lesions. We observed no differences in the occurrence of skin lesions between the Zn supplementation and the Zn-deficient groups compared to their respective control groups. Conclusion:We found no significant effect of Zn on the initiation of NSF-like skin lesions. The results further support data from previous studies highlighting the importance of complex stability of the investigated GBCAs.

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confidence: 99%

Evaluating the role of zinc in the occurrence of fibrosis of the skin: A preclinical study

Pietsch

Pering

Lengsfeld

et al. 2009

Magnetic Resonance Imaging

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Ingestive behaviors and metabolic fuels after central injections of 5-HT1A and 5-HT1D/1B receptors agonists in the pigeon

et al. 2004

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Central administration of zinc reduces salt intake in rats

Castro-e-Silva

Ferreira

Magrani

et al. 2002

Physiology & Behavior

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Central administration of zinc increases renal sodium and potassium excretion in rats

Cited by 3 publications

References 46 publications

Evaluating the role of zinc in the occurrence of fibrosis of the skin: A preclinical study

Evaluating the role of zinc in the occurrence of fibrosis of the skin: A preclinical study

Ingestive behaviors and metabolic fuels after central injections of 5-HT1A and 5-HT1D/1B receptors agonists in the pigeon

Central administration of zinc reduces salt intake in rats

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