Central Administration of Kisspeptin-10 Inhibits Water and Sodium Excretion of Anesthetized Male Rats and the Involvement of Arginine Vasopressin

Ten, Shi-Chao; Gu, Shou-Yong; Niu, Yunfei; An, Xiaofei; Yan, Ming; He, Ming

doi:10.3109/07435801003769995

Cited by 17 publications

(8 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…; Ten et al . ), and to increase mEPSC frequency in vasopressin neurones in brain slices from male rats (Yokoyama et al . ).…”

Section: Discussionmentioning

confidence: 99%

“…I.C.V. kisspeptin has been shown to increase plasma vasopressin concentrations in male rats (Han et al 2010;Ten et al 2010), and to increase mEPSC frequency in vasopressin neurones in brain slices from male rats (Yokoyama et al 2014). While this might represent a sex difference in the regulation of vasopressin neurones by kisspeptin, it is possible that paraventricular nucleus vasopressin neurones respond differently than supraoptic nucleus oxytocin neurones to I.C.V.…”

Section: Effects Of Kisspeptin On Vasopressin Neuronesmentioning

confidence: 99%

See 1 more Smart Citation

Development of an excitatory kisspeptin projection to the oxytocin system in late pregnancy

Seymour

Scott

Augustine

et al. 2016

The Journal of Physiology

View full text Add to dashboard Cite

The hormone oxytocin promotes uterine contraction during parturition. Oxytocin is synthesized by magnocellular neurones in the hypothalamic supraoptic and paraventricular nuclei and is released into the circulation from the posterior pituitary gland in response to action potential firing. Systemic kisspeptin administration increases oxytocin neurone activity to elevate plasma oxytocin levels. Here, immunohistochemistry revealed that rats on the expected day of parturition (day 21 of gestation) had a higher density of kisspeptin-positive fibres in the perinuclear zone surrounding the supraoptic nucleus (which provides dense glutamatergic and GABAergic innervation to the supraoptic nucleus) than was evident in non-pregnant rats. Retrograde tracing showed the kisspeptin projections to the perinuclear zone originated from the hypothalamic periventricular nucleus. Quantitative RT-PCR showed that kisspeptin receptor mRNA, Kiss1R mRNA, was expressed in the perinuclear zone-supraoptic nucleus and that the relative Kiss1R mRNA expression does not change over the course of pregnancy. Finally, intracerebroventricular administration of kisspeptin increased the firing rate of oxytocin neurones in anaesthetized late-pregnant rats (days 18-21 of gestation) but not in non-pregnant rats, or in early- or mid-pregnant rats. Taken together, these results suggest that kisspeptin expression is upregulated in the periventricular nucleus projection to the perinuclear zone of the supraoptic nucleus towards the end of pregnancy. Hence, this input might activate oxytocin neurones during parturition.

show abstract

“…; Ten et al . ), and to increase mEPSC frequency in vasopressin neurones in brain slices from male rats (Yokoyama et al . ).…”

Section: Discussionmentioning

confidence: 99%

Section: Effects Of Kisspeptin On Vasopressin Neuronesmentioning

confidence: 99%

Development of an excitatory kisspeptin projection to the oxytocin system in late pregnancy

Seymour

Scott

Augustine

et al. 2016

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…A recent study demonstrated that icv kisspeptin-10 increases plasma vasopressin after 30 min, with a concurrent decrease in sodium excretion and urine production (17). These observations are most easily be explained by increased vasopressin secretion, which would be expected to result from an increased firing rate of vasopressin neurons.…”

Section: Figmentioning

confidence: 96%

“…Previous studies have shown that iv administration of kisspeptin-10 to female rats increases plasma oxytocin levels (5), whereas intracerebroventricular (icv) injection of kisspeptin-10 to male rats increases plasma vasopressin concentrations (17). To date, there are no reports of the effects of icv kisspeptin on oxytocin levels or of iv kisspeptin on vasopressin levels.…”

mentioning

confidence: 97%

Kisspeptin Activation of Supraoptic Nucleus Neurons in Vivo

Scott

Brown

2011

Endocrinology

View full text Add to dashboard Cite

Oxytocin and vasopressin are synthesized by magnocellular neurosecretory cells in the hypothalamic supraoptic and paraventricular nuclei and are released from the posterior pituitary gland into the circulation. Intravenous administration of the ligand for the G protein-coupled receptor 54 receptor, kisspeptin-10, increases plasma oxytocin levels and intracerebroventricular kisspeptin-10 increases vasopressin levels, indicating that kisspeptin might play a role in various physiological functions via stimulation of oxytocin and vasopressin secretion. Because posterior pituitary hormone secretion is dependent on action potential (spike) discharge, we used in vivo extracellular single unit recording to determine the effects of kisspeptin-10 on supraoptic nucleus neurons in urethane-anaesthetized female rats. Intravenous kisspeptin-10 (100 μg) increased the firing rate of oxytocin neurons from 3.7 ± 0.8 to 4.7 ± 0.8 spikes/sec (P = 0.0004), but only a quarter of vasopressin neurons responded to iv kisspeptin-10, showing a short (<3 sec) high-frequency (>15 spikes/sec) burst of firing. By contrast, intracerebroventricular kisspeptin-10 (2 and 40 μg) did not alter oxytocin or vasopressin neuron firing rate. To investigate the pathway involved in the peripheral action of kisspeptin-10, we used i.p. capsaicin to desensitize vagal afferents, which prevented the i.v. kisspeptin-10-induced increase of oxytocin neuron firing rate. This is the first report to show that peripheral, but not central, kisspeptin-10 increases the activity of oxytocin neurons and a proportion of vasopressin neurons and that endogenous kisspeptin regulation of supraoptic nucleus neurons is likely via vagal afferent input, with kisspeptin acting as a hormone rather than as a neuropeptide in this system.

show abstract

“…Central administration of KP-10 also inhibits sodium excretion and the urine flow, presumably by increasing the plasma vasopressine concentration [30].…”

Section: Discussionmentioning

confidence: 99%

The action of kisspeptin-13 on passive avoidance learning in mice. Involvement of transmitters

Telegdy

Adamik

2013

Behavioural Brain Research

View full text Add to dashboard Cite

Kisspeptins are G protein-coupled receptor ligands originally identified as human metastasis suppressor gene products that have the ability to suppress melanoma and breast cancer metastasis and recently found to play an important role in initiating the secretion of gonadotropin-releasing hormone at puberty. Kisspeptin-13 is an endogenous isoform that consists of 13 amino acids. The action of kisspeptin in the regulation of gonadal function has been widely studied, but little is known as concerns its function in limbic brain structures. In the brain, the gene is transcribed within the hippocampal dentate gyrus. This paper reports on a study the effects of kisspeptin-13 on passive avoidance learning and the involvement of the adrenergic, serotonergic, cholinergic, dopaminergic and GABA-A-ergic, opiate receptors and nitric oxide in its action in mice. Mice were pretreated with a nonselective α-adrenergic receptor antagonist, phenoxybenzamine, an α2-adrenergic receptor antagonist, yohimbine, a β-adrenergic receptor antagonist, propranolol, a mixed 5-HT1/5-HT2 serotonergic receptor antagonist, methysergide, a nonselective 5-HT2 serotonergic receptor antagonist, cyproheptadine, a nonselective muscarinic acetylcholine receptor antagonist, atropine, D2, D3, D4 dopamine receptor antagonist, haloperidol, a γ-aminobutyric acid subunit A (GABAA) receptor antagonist, bicuculline, naloxone, a nonselective opioid receptor antagonist and nitro-l-arginine, a nitric oxide synthase inhibitor. Kisspeptin-13 facilitated learning and memory consolidation in a passive avoidance paradigm. Phenoxybenzamine, yohimbine, propranolol, methysergide, cyproheptadine, atropine, bicuculline and nitro-l-arginine prevented the action of kisspeptin-13 on passive avoidance learning, but haloperidol and naloxone did not block the effects of kisspeptin-13. The results demonstrated that the action of kisspeptin-13 on the facilitation of passive avoidance learning and memory consolidation is mediated, at least in part, through interactions of the α2-adrenergic, beta-adrenergic, 5-HT2 serotonergic, muscarinic cholinergic and GABA-A-ergic receptor systems and nitric oxide.

show abstract

Central Administration of Kisspeptin-10 Inhibits Water and Sodium Excretion of Anesthetized Male Rats and the Involvement of Arginine Vasopressin

Abstract: Central administration of kisspeptin-10 could inhibit sodium excretion and urine flow in anesthetized male rats, which is probably mediated by increasing the plasma AVP concentration and is independent of plasma ANP concentration and renal sympathetic nerve activity.

Cited by 17 publications

References 16 publications

Development of an excitatory kisspeptin projection to the oxytocin system in late pregnancy

Development of an excitatory kisspeptin projection to the oxytocin system in late pregnancy

Kisspeptin Activation of Supraoptic Nucleus Neurons in Vivo

The action of kisspeptin-13 on passive avoidance learning in mice. Involvement of transmitters

Contact Info

Product

Resources

About