Central administration of endocannabinoids exerts bimodal effects in food intake of rainbow trout

Díaz-Rúa, Adrián; Chivite, Mauro; Comesaña, Sara; Velasco, Cristina; Soengas, José L.; Conde-Sieira, Marta

doi:10.1016/j.yhbeh.2021.105021

Cited by 8 publications

(4 citation statements)

References 54 publications

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“…AEA injection (i.e., the 14-fold-higher dose) did not increase feed intake in the one cow studied. This result is in line with earlier findings by Díaz-Rúa et al (2021) and Jamshidi and Taylor (2001), showing that high AEA doses do not elicit changes in food intake, whereas low doses induce orexigenic effects in rainbow trout and rats.…”

Section: Effects Of Intracerebroventricular Anandamide Administration...supporting

confidence: 93%

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Effects of intracerebroventricular anandamide administration on feed intake and milk yield of dairy cows

Kuhla

Ackern

2022

JDS Communications

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Section: Effects Of Intracerebroventricular Anandamide Administration...supporting

confidence: 93%

“…administration of 10 µg relative to 1 and 0.1 µg of AEA decreased food intake of rats (Gómez et al, 2002). Bimodal effects of AEA concentrations on food intake have also been reported in rainbow trout, with the higher doses of AEA (5 vs. 2 ng/100 g of BW) not affecting food intake levels (Díaz-Rúa et al, 2021).…”

Section: Short Communication Physiologymentioning

confidence: 76%

Effects of intracerebroventricular anandamide administration on feed intake and milk yield of dairy cows

Kuhla

Ackern

2022

JDS Communications

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“…to support this assumption. Previous studies reported increased FAAH mRNA abundance after AEA administration 61 . However, another reason for the change in FAAH mRNA abundance could be the higher leptin concentration in the AEA group.…”

Section: Discussionmentioning

confidence: 93%

The effect of N-arachidonoylethanolamide administration on energy and fat metabolism of early lactating dairy cows

Schwerdtfeger,

Sauerwein,

Albrecht

et al. 2023

Sci Rep

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The aim of the study was to investigate the effect of N-arachidonoylethanolamide (AEA), an endocannabinoid with orexigenic characteristics, on plasma endocannabinoid concentrations, feed intake, energy balance, lipomobilisation, and hepatic lipid metabolism of early-lactating dairy cows. The experiment involved 10 pairs of Holstein half-sibling cows (end of 2nd–3rd pregnancy). Half-sibs of each pair were randomly assigned to either AEA (n = 10) or control (CON) group (n = 10). From day 1 to 30 postpartum, the AEA group received 5 intraperitoneal injections per week of 3 µg/kg body weight AEA and the CON group 0.9% NaCl. In week 1–3 postpartum, AEA administration had no effect on dry matter intake, body weight, or lipomobilisation, but increased plasma triglyceride concentration on d 21 p.p. and mRNA abundances of genes related to hepatic triglyceride synthesis. In week 4 postpartum, the AEA group showed reduced feed intake and whole-body carbohydrate oxidation, but increased whole-body fat oxidation and hepatic lipid accumulation, likely as a result of a counter-regulatory leptin increase. In conclusion, the present study shows a tissue-specific AEA insensitivity and may point to a leptin-controlled regulation of the ECS in early-lactation.

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“…The knowledge about regulation of food intake in fish is mostly restricted to homeostatic mechanisms. Few available studies addressed hedonic mechanisms including our recent studies regarding the involvement of endocannabinoids ( Díaz-Rúa et al, 2020a , b , 2021 ). The involvement of opioids in food intake regulation is a reasonable hypothesis based on findings achieved in several fish species.…”

Section: Introductionmentioning

confidence: 99%

The Opioid System in Rainbow Trout Telencephalon Is Probably Involved in the Hedonic Regulation of Food Intake

et al. 2022

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We hypothesize that opioids are involved in the regulation of food intake in fish through homeostatic and hedonic mechanisms. Therefore, we evaluated in rainbow trout (Oncorhynchus mykiss) hypothalamus and telencephalon changes in precursors, endogenous ligands and receptors of the opioid system under different situations aimed to induce changes in the homeostatic (through fasted/fed/refed fish) and hedonic (through feeding fish a control or a palatable high-fat diet) regulation of food intake. No major changes occurred in parameters assessed related with the nutritional condition of fish (fasted/fed/refed), allowing us to suggest that the opioid system seems not to have an important role in the homeostatic regulation of food intake in rainbow trout. The responses observed in telencephalon of rainbow trout fed the palatable high-fat diet included a decrease in mRNA abundance of the opioid precursor penka, in a way similar to that known in mammals, and increased mRNA abundance of the opioid receptors oprd1 and oprk1 supporting a role for telencephalic opioid system in the hedonic regulation of food intake in fish.

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Central administration of endocannabinoids exerts bimodal effects in food intake of rainbow trout

Cited by 8 publications

References 54 publications

Effects of intracerebroventricular anandamide administration on feed intake and milk yield of dairy cows

Effects of intracerebroventricular anandamide administration on feed intake and milk yield of dairy cows

The effect of N-arachidonoylethanolamide administration on energy and fat metabolism of early lactating dairy cows

The Opioid System in Rainbow Trout Telencephalon Is Probably Involved in the Hedonic Regulation of Food Intake

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