Central administration of cocaine- and amphetamine-regulated transcript inhibits food intake in chicks

Tachibana, Tetsuya; Takagi, Tohru; Tomonaga, Shozo; Ohgushi, Atsushi; Ando, Ryuichi; Denbow, D. Michael; Furuse, Mitsuhiro

doi:10.1016/s0304-3940(02)01321-6

Cited by 65 publications

(29 citation statements)

References 16 publications

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“…In birds the evidence for a role of CARTp in regulating feeding behavior is scarce. As mentioned before, intracerebroventricular injection of CARTp alters feeding behavior in chickens (Tachibana et al, ), and recently Cai et al () showed that fasting downregulates CART mRNA in the hypothalamus of chickens. Our results provide further support to a role of CARTp in mediating the regulation of feeding behavior in birds.…”

Section: Discussionmentioning

confidence: 76%

“…In birds, the CART gene is present, and the peptide encoded by it is similar to that in other vertebrates (Murashita et al, ; Cai et al, ). Furthermore, injection of human CARTp into the central nervous system of chicks ( Gallus domesticus ) inhibits food intake (Tachibana et al, ), suggesting that CARTp is expressed and active in the brain of birds. Nevertheless, no characterization of the distribution of CARTp in the avian brain has yet been published.…”

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confidence: 99%

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Immunohistochemical localization of cocaine‐ and amphetamine‐regulated transcript peptide (CARTp) in the brain of the pigeon (Columba livia) and zebra finch (Taeniopygia guttata)

Gutiérrez-Ibáñez

Iwaniuk

Jensen

et al. 2016

J of Comparative Neurology

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Cocaine- and amphetamine-regulated transcript peptides (CARTp) are neuropeptides that act as neurotransmitters in the brain of vertebrates. The expression of CARTp has been characterized in teleosts, amphibians, and several mammalian species, but comparative data in reptiles and birds are nonexistent. In this study, we show the distribution of immunoreactivity against CART peptides (CARTp-ir) in the brains of two bird species: the pigeon (Columba livia) and zebra finch (Taeniopygia guttata). We found CARTp-ir cells and terminals in the brains of both, but no major differences between the two species. As in mammals, teleost fish, and amphibians, CARTp-ir terminals and cells were abundant in subpallial regions, particularly the striatum and nucleus accumbens. We also found CARTp-ir cells and terminals in the hypothalamus, and a large number of CARTp-ir terminals in the substantia nigra, ventral tegmental area, periaqueductal gray, parabrachial nucleus, and dorsal vagal complex. However, in contrast to other vertebrates, CARTp-ir was not found in the olfactory bulb. In addition there was almost no CARTp-ir in the pallium or the hippocampal formation, and little CARTp-ir in the cerebellum. The conserved expression of CARTp in the subpallium, hypothalamus, and dorsal vagal complex of birds suggests that some of the functions of CARTp, such as regulation of food intake and interactions with the social control network and mesolimbic reward system, are conserved among vertebrates. J. Comp. Neurol. 524:3747-3773, 2016. © 2016 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 76%

mentioning

confidence: 99%

Immunohistochemical localization of cocaine‐ and amphetamine‐regulated transcript peptide (CARTp) in the brain of the pigeon (Columba livia) and zebra finch (Taeniopygia guttata)

Gutiérrez-Ibáñez

Iwaniuk

Jensen

et al. 2016

J of Comparative Neurology

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“…In goldfish, cart brain expression also increases following treatment with amphetamine (47). CART is a potent anorexigenic peptide in mammals (48–50) and birds (51), and CART injections inhibit food intake in goldfish (52). …”

Section: Central Controlmentioning

confidence: 99%

“…agrp mRNA abundance in the hypothalamus of rainbow trout (59) and Senegalese sole (60) also responds to changes in the levels of specific fatty acids. Altogether, it is suggested that the role of AgRP in energy homeostasis and its relation to the melanocortin system is conserved across vertebrates (51, 145). …”

Section: Central Controlmentioning

confidence: 99%

Appetite-Controlling Endocrine Systems in Teleosts

et al. 2017

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Mammalian studies have shaped our understanding of the endocrine control of appetite and body weight in vertebrates and provided the basic vertebrate model that involves central (brain) and peripheral signaling pathways as well as environmental cues. The hypothalamus has a crucial function in the control of food intake, but other parts of the brain are also involved. The description of a range of key neuropeptides and hormones as well as more details of their specific roles in appetite control continues to be in progress. Endocrine signals are based on hormones that can be divided into two groups: those that induce (orexigenic), and those that inhibit (anorexigenic) appetite and food consumption. Peripheral signals originate in the gastrointestinal tract, liver, adipose tissue, and other tissues and reach the hypothalamus through both endocrine and neuroendocrine actions. While many mammalian-like endocrine appetite-controlling networks and mechanisms have been described for some key model teleosts, mainly zebrafish and goldfish, very little knowledge exists on these systems in fishes as a group. Fishes represent over 30,000 species, and there is a large variability in their ecological niches and habitats as well as life history adaptations, transitions between life stages and feeding behaviors. In the context of food intake and appetite control, common adaptations to extended periods of starvation or periods of abundant food availability are of particular interest. This review summarizes the recent findings on endocrine appetite-controlling systems in fish, highlights their impact on growth and survival, and discusses the perspectives in this research field to shed light on the intriguing adaptations that exist in fish and their underlying mechanisms.

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“…In the bombesin-like peptides, gastrin-releasing peptide (GRP) and neuromedin B (both are homologs of bombesin) also suppress food intake after central injection (Tachibana et al, 2010b). Other peptides including vasotocin, mesotocin, neuromedin S, neuromedin U, neuropeptide FF, neuropeptide K, neuropeptide S, substance P, cocaine- and amphetamine-regulated transcript, and calcitonin gene-related peptide were reported to suppress feeding behavior (Tachibana et al, 2003b, 2004b, 2010a,c; Shousha et al, 2005b; Cline et al, 2007a,b, 2009a; Prall and Cline, 2008; Masunari et al, 2013). Most of the above are also known as anorexigenic peptides in mammalian species, although GHRH is thought to be an orexigenic neuropeptide in mammals.…”

Section: Anorexigenic Neuropeptidesmentioning

confidence: 99%

Neuropeptide Control of Feeding Behavior in Birds and Its Difference with Mammals

Tachibana

Tsutsui

2016

Front. Neurosci.

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Feeding is an essential behavior for animals to sustain their lives. Over the past several decades, many neuropeptides that regulate feeding behavior have been identified in vertebrates. These neuropeptides are called “feeding regulatory neuropeptides.” There have been numerous studies on the role of feeding regulatory neuropeptides in vertebrates including birds. Some feeding regulatory neuropeptides show different effects on feeding behavior between birds and other vertebrates, particularly mammals. The difference is marked with orexigenic neuropeptides. For example, melanin-concentrating hormone, orexin, and motilin, which are regarded as orexigenic neuropeptides in mammals, have no effect on feeding behavior in birds. Furthermore, ghrelin and growth hormone-releasing hormone, which are also known as orexigenic neuropeptides in mammals, suppress feeding behavior in birds. Thus, it is likely that the feeding regulatory mechanism has changed during the evolution of vertebrates. This review summarizes the recent knowledge of peptidergic feeding regulatory factors in birds and discusses the difference in their action between birds and other vertebrates.

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Central administration of cocaine- and amphetamine-regulated transcript inhibits food intake in chicks

Cited by 65 publications

References 16 publications

Immunohistochemical localization of cocaine‐ and amphetamine‐regulated transcript peptide (CARTp) in the brain of the pigeon (Columba livia) and zebra finch (Taeniopygia guttata)

Immunohistochemical localization of cocaine‐ and amphetamine‐regulated transcript peptide (CARTp) in the brain of the pigeon (Columba livia) and zebra finch (Taeniopygia guttata)

Appetite-Controlling Endocrine Systems in Teleosts

Neuropeptide Control of Feeding Behavior in Birds and Its Difference with Mammals

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