Central Action of some Cholinergic Drugs (Arecaidine Esters) and Nicotine on Blood Pressure and Heart Rate of Cats

Porsius, A. J.; Zwieten, P. A. van

doi:10.1016/s0079-6123(08)62719-3

Cited by 6 publications

(4 citation statements)

References 2 publications

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“…These results indicate that the activa tion of peripheral as well as central musca rinic receptors by buxaminol-E may account for its hypotensive effect. This suggestion is in agreement with observations that injec tion of a muscarinic agonist [ 13] and physostigmine [14] into the vertebral artery of the cat induced a decrease in blood pressure. Our results are in accordance with the find ing that the blood pressure-decreasing effect of a mixture of buxus alkaloids in rabbits was depressed by atropine [15].…”

Section: Discussionsupporting

confidence: 92%

Effect of the Steroidal Alkaloid Buxaminol-E on Blood Pressure, Acetylcholinesterase Activity and (<sup>3</sup>H)Quinuclidinyl Benzilate Binding in Cerebral Cortex

Kvaltínová¹,

Lukovic²,

Máchová³

et al. 1991

Pharmacology

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Pharmacological properties of the steroidal alkaloid buxaminol-E isolated from Buxus sempervirens varietas bullata were studied in relation to the cholinergic nervous system. In anaesthetised cats buxaminol-E (1.25 μmol/kg) initially induced a small short-lasting increase in blood pressure followed by marked hypotension. Atropine (1.47 μmol/kg) inhibited the hypotensive effect almost completely and methylatropine (1.47 μmol/kg) partially. Buxaminol-E and the muscarinic agonists McN-A-343 and bethanechol inhibited the binding of the muscarinic antagonist (³H)quinuclidinyl benzilate in cat and rabbit cerebral cortex membranes in decreasing order of potency. In about 10-fold higher concentrations they also inhibited acetylcholinesterase activity in cat cerebral cortex in the same order of potency. The results suggest that the hypotensive effect of buxaminol-E could be due to both central and peripheral activation of muscarinic receptors, and to a lesser degree to inhibition of acetylcholinesterase activity.

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Section: Discussionsupporting

confidence: 92%

Effect of the Steroidal Alkaloid Buxaminol-E on Blood Pressure, Acetylcholinesterase Activity and (<sup>3</sup>H)Quinuclidinyl Benzilate Binding in Cerebral Cortex

Kvaltínová¹,

Lukovic²,

Máchová³

et al. 1991

Pharmacology

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“…APE had been shown to exert the negative chronotropic and inotropic effects [11][12][13] and has been considered as a potential candidate for the treatment of Alzheimer's disease [6,7]. However, the ionic mechanisms that might underlie the cardiovascular effects of APE are unclear.…”

Section: Discussionmentioning

confidence: 99%

“…APE has been shown to have cardiovascular effects. APE produces negative chronotropic and inotropic effects in isolated atria [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Activation of muscarinic K+ channels by arecaidine propargyl ester in isolated guinea-pig atrial myocytes

Chen

2005

J Biomed Sci

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Arecaidine propargyl ester (APE) was developed as a potential candidate compound for the treatment of Alzheimer's disease. APE has been shown to have cardiovascular effects. APE produces negative chronotropic and inotropic effects in isolated atria. However, the ionic mechanisms underlying the cardiovascular effects of APE in guinea-pig atria are unclear. The aims of this study were: (1) to examine the shortening effect of APE on action potential duration (APD) and to compare the difference in potency between APE and muscarine in isolated single guinea-pig atrial myocytes by using the current clamp method, (2) to examine by using patch clamp techniques the ionic mechanisms underlying the cardiac effects of APE, and (3) to determine whether the cardiac effects caused by APE affect the usefulness of APE as a potential candidate for the treatment of Alzheimer's disease. The APE significantly reduced the APD in guinea-pig atria and produced no direct effect on ventricular myocytes. APE is approximately 20 times as potent as muscarine in shortening the APD. Attenuation of the APD was consistently accompanied by a hyperpolarization of the resting membrane potential in a concentration-dependent manner. The APE activated muscarinic K+ channels and increased potassium conductance in guinea-pig atrial myocytes. In the cell-attached configuration, the APE contained in the pipette increased the channel-opening probability and decreased the closed-state time interval. The proposal that APE can be used as a potential remedy for the treatment of Alzheimer's disease should be taken into consideration the undesirable cardiovascular side effects that APE causes at lower concentrations.

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“…In the 1930s it was shown that arecoline, one of the major alkaloids in the areca nut, had an effect similar to that of nicotine in stimulating the central nervous system, increasing breathing and perspiration while keeping the heart rate steady (ibid. :291; Chopra et al 1956:23;Juptner 1968;Porsius et al 1978). For reasons of this sort, most of the general literature still classifies the betel quid as a mild stimulant (Lewin 1964:239;Penzer 1956:291;Emboden 1979:146;Burton-Bradley 1966:746).…”

Section: Betel Tobacco and The Brainmentioning

confidence: 99%

From Betel-Chewing to Tobacco-Smoking in Indonesia

Reid¹

1985

J of Asian Stud

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Indonesians, like other Southeast Asians, have been extensive users of mild narcotic analgesics throughout history. Until a century ago the most widespread narcotic was the chewed quid of betel, comprising the areca nut, betel leaves, lime, and sundry optional additives. Europeans introduced both tobacco and opium around 1600, and Indonesians quickly took up the growing of tobacco. Initially smoked by a relatively small elite, tobacco became used almost universally as part of the betel chew by the end of the eighteenth century. At the end of the nineteenth century cigarette-smoking for men became associated with the transformation to “modern” attitudes, and it rapidly replaced betel-chewing. Today virtually all Indonesian men smoke and virtually none chew betel. Among women betel-chewing has no such substitute and is disappearing more slowly.Tobacco has relaxant and sedative effects similar to betel. Whereas the betel ingredients were very cheap, tobacco now consumes about 5 percent of the incomes of Indonesian families, including the poorest. Although betel-chewing provided protection against tooth decay, intestinal parasites, and bacteria, tobacco-smoking is injurious to health in a variety of ways.

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Central Action of some Cholinergic Drugs (Arecaidine Esters) and Nicotine on Blood Pressure and Heart Rate of Cats

Cited by 6 publications

References 2 publications

Effect of the Steroidal Alkaloid Buxaminol-E on Blood Pressure, Acetylcholinesterase Activity and (<sup>3</sup>H)Quinuclidinyl Benzilate Binding in Cerebral Cortex

Effect of the Steroidal Alkaloid Buxaminol-E on Blood Pressure, Acetylcholinesterase Activity and (<sup>3</sup>H)Quinuclidinyl Benzilate Binding in Cerebral Cortex

Activation of muscarinic K+ channels by arecaidine propargyl ester in isolated guinea-pig atrial myocytes

From Betel-Chewing to Tobacco-Smoking in Indonesia

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