2020
DOI: 10.1101/2020.12.20.423651
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Centimeter-scale quorum sensing dictates collective survival of differentiating embryonic stem cells

Abstract: SUMMARY“Community effect” conventionally describes differentiation occurring only when enough cells help their local (micrometers-scale) neighbors differentiate. Although new community effects are being uncovered for myriad differentiations, macroscopic-scale community effects - fates of millions of cells all entangled across centimeters - remain elusive. We found that differentiating mouse Embryonic Stem (ES) cells that are scattered as individuals over many centimeters form one macroscopic entity via long-ra… Show more

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References 106 publications
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