Purpose
To determine the variability in CT measurements of proximal thoracic aortic diameters obtained using double-oblique short axis and semiautomatic centerline analysis techniques.
Methods
Institutional review board approval, with waiver of informed consent, was obtained for this HIPAA-compliant, retrospective study. Cardiac gated thoracic aortic CT scans were evaluated in 25 patients. Maximum aortic diameter measurements at the annulus, sinuses, sinotubular junction and ascending aorta were generated using double-oblique short axis and semiautomatic centerline analysis techniques. Intraobserver and interobserver variability and variability between techniques were assessed using the Wilcoxon signed rank test, Spearman’s correlation coefficients and Bland-Altman plots.
Results
Mean intraobserver diameter differences using double oblique views ranged from −0.3 – 0.6 mm. The 95% confidence interval for difference in diameters was ±2.4 – ±5.1 mm for radiologist #1 and ±2.6 – ±5.2 mm for radiologist #2, depending on location. Mean intraobserver diameter differences using centerline analysis ranged from 0.2 – 2.3 mm, and the 95% confidence interval for difference in diameters was ±2.0 – ±4.6 mm, depending on location. Significant interobserver differences were seen for both double oblique views and centerline analysis. Measurements obtained using the two methods were strongly correlated (r = 0.81 – 0.99), although they were consistently larger using centerline analysis (95% confidence interval, ±1.8 – ±3.2 mm).
Conclusions
Although measurement variability of the proximal thoracic aorta was generally low using double oblique and centerline analysis techniques, differences of up to approximately 5 mm in diameter occurred within the 95% confidence interval. Neither technique was clearly more reliable than the other.