Centering the Needs of Transgender, Nonbinary, and Gender-Diverse Populations in Neuroendocrine Models of Gender-Affirming Hormone Therapy

Aghi, Krisha; Goetz, Teddy G.; Pfau, Daniel R.; Sun, Simón D.; Roepke, Troy A.; Guthman, Eartha Mae

doi:10.1016/j.bpsc.2022.07.002

Cited by 7 publications

(3 citation statements)

References 137 publications

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“…For instance, there have been significant efforts to be inclusive of SGMs in toxicology research and medicine, with researchers further outlining how animal models can be used to address the health of individuals participating in gender affirming hormone therapies. 70 , 71 Additionally, in the realm of environmental justice, focus is being dedicated to the disparity in environmental exposures for marginalized populations such as LGBTQIA+ individuals. 72 Concepts such as the public health exposome can guide these efforts to translate the findings from exposomic research into tangible changes.…”

Section: Incorporating Sex and Gender In Exposome Researchmentioning

confidence: 99%

Exposomics as a tool to investigate differences in health and disease by sex and gender

et al. 2023

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The health and disease of an individual is mediated by their genetics, a lifetime of environmental exposures, and interactions between the two. Genetic or biological sex, including chromosome composition and hormone expression, may influence both the types and frequency of environmental exposures an individual experiences, as well as the biological responses an individual has to those exposures. Gender identity, which can be associated with social behaviors such as expressions of self, may also mediate the types and frequency of exposures an individual experiences. Recent advances in exposome-level analysis have progressed our understanding of how environmental factors affect health outcomes; however, the relationship between environmental exposures and sex- and gender-specific health remains underexplored. The comprehensive, non-targeted, and unbiased nature of exposomic research provides a unique opportunity to systematically evaluate how environmental exposures interact with biological sex and gender identity to influence health. In this forward-looking narrative review, we provide examples of how biological sex and gender identity influence environmental exposures, discuss how environmental factors may interact with biological processes, and highlight how an intersectional approach to exposomics can provide critical insights for sex- and gender-specific health sciences.

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Section: Incorporating Sex and Gender In Exposome Researchmentioning

confidence: 99%

Exposomics as a tool to investigate differences in health and disease by sex and gender

et al. 2023

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“…As described by the authors, careful use of minimally invasively collected biomarker samples as part of well‐designed mixed‐methods studies potentially allow the identification of specific pathways leading to the embodiment of adverse social conditions; in doing so, researchers can better understand risk for poor health and well‐being, and envision potential pathways for intervention. This research approach is already being applied (e.g., Aghi et al, 2022; DuBois & Juster, 2022).…”

Section: Introductionmentioning

confidence: 99%

Minimally invasive biomarkers in human population biology research, part 2: An introduction to the special issue

Snodgrass

2022

American J Hum Biol

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Over the past several decades, biomarkers have become indispensable tools in human biology, allowing researchers to investigate biocultural and evolutionary questions and to generate basic data on health and well-being. Human biologists are central players in biomarker methods development, pioneering the creation of "field friendly," minimally invasively collected biomarker approaches, as well as leading the innovative use of biomarkers, most notably to map the complex pathways from social and environmental conditions to altered physiology to health effects. This special issue, Part 2 of a collection focused on minimally invasively collected biomarkers, is comprised of nine papers that jointly contribute to driving the science of biomarker methods development and application. This compilation of papers engages with topics such as biological normalcy, ecoimmunology, and the ethics of working with vulnerable and underserved populations. It also focuses attention on research areas at present not emphasized in human biology such as bone turnover markers as a window onto osteoporosis and osteoarthritis and the use of cancer-related biomarkers in population screening and epidemiology. Taken together, these papers help draw the roadmap for future biomarker work, emphasizing: (1) the need for systematic and transparent approaches to assay validation, with open access publication; (2) simultaneous measurement of multiple biomarkers and expanded use of instrument platforms that increase the range of physiological, genomics, and omics markers available to researchers; and, (3) increased attention to ethics and researcher responsibilities, encouraging a mindset that recognizes our obligation to provide benefits to individuals and communities and to help redress past abuses.

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“…To address this exigent issue, we recently published a review outlining how to best design such studies [ 5 ]. Studies on the influence of estrogen-based GAHT (E-GAHT)/testosterone-based GAHT (T-GAHT) on physiological or neurological processes should be evaluated on whether “classic” endocrinological techniques (gonadectomy with surgical pellet implantation) or new GAHT models are most appropriate.…”

mentioning

confidence: 99%

Using Animal Models for Gender-Affirming Hormone Therapy

Aghi,

Goetz,

Pfau

et al. 2023

Journal of the Endocrine Society

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We have recently proposed experimental design guidelines and areas of study for preclinical rodent models of gender-affirming hormone therapy in neuroscience. These guidelines also apply to any field subject to the influences of gonadal steroid hormones, including metabolism and growth, cancer, and physiology. This perspective briefly describes our suggestions for these fields. Studying the effects of exogenous steroid hormones will have translational benefits for the community. We also discuss the need for equitable practices for cisgender scientists who wish to implement these guidelines and engage with the community. It is necessary that community-informed practices are implemented in preclinical research to maximize the benefit to transgender, nonbinary, and/or gender diverse (TNG) healthcare, which is currently in jeopardy in the United States, Europe, and across the globe.

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Centering the Needs of Transgender, Nonbinary, and Gender-Diverse Populations in Neuroendocrine Models of Gender-Affirming Hormone Therapy

Cited by 7 publications

References 137 publications

Exposomics as a tool to investigate differences in health and disease by sex and gender

Exposomics as a tool to investigate differences in health and disease by sex and gender

Minimally invasive biomarkers in human population biology research, part 2: An introduction to the special issue

Using Animal Models for Gender-Affirming Hormone Therapy

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