Center-based patient care enhances survival of elderly patients suffering from peripheral arterial disease

Abstract

These data imply that multi-morbid elderly PAD patients still benefit by intensified specialist care compared to the usual primary care setting. KEY MESSAGES Center-based patient care improves survival in patients with peripheral arterial disease; mortality was reduced from 82 to 21 events per 1000 patient-years (rate ratio 0.26). Mortality was related to age (HR 1.46), CRP (HR 1.36), and nephropathy (HR 2.7). A multifactorial approach combining adequate drug prescription, accomplishment of agreed goals and repetitive training to initiate, implement, and persist treatment adaptations was applied.

Thrombospondin-4 increases with the severity of peripheral arterial disease and is associated with diabetes

“…This study was approved by the institutional ethics committee and follows the Declaration of Helsinki and Good Clinical Practice. Frozen blood samples from the VMC Vienna cohort [21] were used for this study. Patient recruitment and characteristics have been previously described [21].…”

“…Frozen blood samples from the VMC Vienna cohort [21] were used for this study. Patient recruitment and characteristics have been previously described [21]. In brief, patients with stable PAD (Fontaine I-II) ranging from 40-90 years were included in this cohort.…”

From the eye into the foot?

“…Likewise, Bartnik et al [4] demonstrated an increase of previously unknown prediabetes and diabetes in patients with myocardial infarction to 31% remaining normal glucose tolerant, 26% to have previously unknown prediabetes and 43% overt diabetes mellitus, of which 28% were unknown. In contrast, Höbaus et al [5], after serial testing, demonstrated only 10% of PAD patients remaining normal glucose tolerant, 42% to have prediabetes and 48% to have diabetes mellitus, of which 40% were unknown.…”

Vascular peroxidase 1 is independently associated with worse kidney function in patients with peripheral artery disease

“…The current investigation is part of the prospective VMC (vascular medicine center) Vienna observational study of PAD-patients [17], and was designed as exploratory data analyses of longitudinally acquired data. Research participants were recruited at the Division of Angiology, Department of Medicine II of the Medical University and General Hospital of Vienna.…”

“…Research participants were recruited at the Division of Angiology, Department of Medicine II of the Medical University and General Hospital of Vienna. The study included women and men between 40 and 90 years of age, with PAD Fontaine stage I or stage II, and excluded patients having type 1 diabetes mellitus, serum creatinine level above 3 mg/dL, hormone replacement therapy, connective tissue disease, malignant disease, or critical illness within the last six months [17]. Based on the eligibility criteria of the main study, a subset of 236 stable participants, who returned for the first followup visit at 6 months, were enrolled for the purpose of the current study.…”