Centenarians and their hearts: A prospective registry with comprehensive geriatric assessment, electrocardiogram, echocardiography, and follow-up

Martínez‐Sellés, Manuel; Villa, Bernardo García de la; Cruz-Jentoft, Alfonso J.; Vidán, María Teresa; Gil, Pedro; Cornide, Luis; Cortés, Miriam Ramos; Guerrero, José L.; Cerviño, Sonia María Barros; Castro, Olalla; Pareja, Teresa Fernández; Sánchez, E.; Cimera, D.; Vigara, Marta; Balaguer, Javier; Jimenez, Maria; Fernández, Fernando Veiga; Juanatey, Carlos González; Fernández, Ana Testa; Nozal, Jesús Mateos del; Vázquez, Sandra; Urueña, Noelia; Díaz, Javier López

doi:10.1016/j.ahj.2015.03.005

Cited by 29 publications

(23 citation statements)

References 26 publications

(45 reference statements)

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“…Permanent atrial fibrillation in our patients (20.9 %) occurred more frequently than observed by Klich-Raczka et al (2003) (8.6 %) and Basile et al (2012) (11.9 %), but less often than observed by Martínez-Sellés et al (2015) (26.2 %), Rabunal-Rey et al (2012) (26.3 %), or Lakkireddy et al (2003) (29.5 %). Rabunal-Rey et al (2012) demonstrated that atrial fibrillation is an independent risk factor for mortality.…”

Section: Discussionsupporting

confidence: 42%

“…By contrast, Basile et al (2012) did not find significant differences in age of death in relation to electrocardiographic findings. Lakkireddy et al (2003) and Martínez-Sellés et al (2015) did not report any relationship between ECG findings and mortality in centenarians.…”

Section: Discussionmentioning

confidence: 92%

“…Normal ECGs were observed in 5.7 % of 35 (Klich-Raczka et al 2003), 7.6 % of 132 (Lakkireddy et al 2003), 8.8 % of 80 (Rabunal-Rey et al 2012), 16.7 % of 42 (Basile et al 2012), and 26.2 % of 103 centenarians (Martínez-Sellés et al 2015) in different study participants.…”

Section: Discussionmentioning

confidence: 94%

“…In studies performed by Lakkireddy et al (2003) and Basile et al (2012), ECG features of LVH were found in 3 to 31 % of study participants. Martínez-Sellés et al (2015) used echocardiography to diagnose left ventricular hypertrophy in 45 % of 100 centenarians, while only 5.1 % had ECG features of LVH. False-negative ECG-LVH may be associated with hypertension, increased systolic blood pressure, and prolonged QRS (Bacharova et al 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Estes et al (2015) demonstrated that the Romhilt–Estes score, traditionally used for ECG detection of LVH, may be applied to predict adverse outcomes in the general population. Despite poor correlation between electrocardiographic and echocardiographic features of LVH in centenarians (Martínez-Sellés et al 2015), it seems reasonable to explore a possible association between ECG findings, especially LVH features, and survival probability in this specific age group. We also studied associations between ECG features and a range of clinical, metabolic, and inflammatory markers to ascertain possible influence on ECG features.…”

Section: Introductionmentioning

confidence: 98%

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ECG low QRS voltage and wide QRS complex predictive of centenarian 360-day mortality

Szewieczek

Gąsior

Duława

et al. 2016

AGE

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We examined the electrocardiographic (ECG) findings of centenarians and associated them with >360-day survival. Physical and functional assessment, resting electrocardiogram and laboratory tests were performed on 86 study participants 101.9 ± 1.2 years old (mean ± SD) (70 women, 16 men) and followed for at least 360 days. Centenarian ECGs were assessed for left ventricular hypertrophy (LVH) according to the Romhilt–Estes score, Sokolow–Lyon criteria and Cornell voltage criteria which were positive for 12.8, 6.98, and 10.5 % of participants, respectively. Fifty-two study participants (60 %) survived ≥360 days. Multivariate logistic regression analysis revealed a negative relationship between 360-day survival and the following: R II <0.45 mV adjusted for CRP (odds ratio (OR) = 0.108, 95 % confidence interval (CI) = 0.034–0.341, P < .001), R aVF < 0.35 mV adjusted for CRP (OR = 0.151, 95 % CI = 0.039–0.584, P < .006), Sokolow–Lyon voltage <1.45 mV adjusted for CRP (OR = 0.178, 95 % CI = 0.064–0.492, P = .001), QRS ≥90 ms adjusted for CRP (OR = 0.375, 95 % CI = 0.144–0.975, P = .044), and Romhilt–Estes score ≥5 points adjusted for sex and Barthel Index (OR = 0.459, 95 % CI = 0.212–0.993, P = .048) in single variable ECG models. QRS voltage correlated positively with systolic and pulse pressure, serum vitamin B12 level, sodium, calcium, phosphorous, TIMP-1, and eGFR. QRS voltage correlated negatively with BMI, WHR, serum leptin, IL-6, TNF-α, and PAI-1 levels. QRS complex duration correlated positively with CRP; QTc correlated positively with TNF-α. Results suggest that Romhilt–Estes LVH criteria scores ≥5 points, low ECG QRS voltages (Sokolow–Lyon voltage <1.45 mV), and QRS complexes ≥90 ms are predictive of centenarian 360-day mortality.

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Section: Discussionsupporting

confidence: 42%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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ECG low QRS voltage and wide QRS complex predictive of centenarian 360-day mortality

Szewieczek

Gąsior

Duława

et al. 2016

AGE

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Rationale and design of the FELICITAR registry (Frailty Evaluation After List Inclusion, Characteristics and Influence on Transplantation and Results)

Ayesta

Astiz

Masa

et al. 2018

Clinical Cardiology

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Frailty reflects a state of decreased physiological reserve and vulnerability to stressors. Its prevalence among patients with cardiovascular disease is as high as 60%. Frailty is associated with a poor prognosis for patients with heart failure, increasingly frequent hospitalization, and death. The recent published listing criteria for heart transplantation of the International Society for Heart and Lung Transplantation recommend assessing frailty (class IIb recommendation, level of evidence C). However, this recommendation is not based on prospective studies, and frailty scores have only been validated in patients age > 65 years. The aim of the FELICITAR registry (Frailty Evaluation After List Inclusion, Characteristics and Influence on Transplantation and Results) is to assess the impact of frailty on prognosis before and after heart transplantation. A series of 100 patients from 3 Spanish centers will be included as soon as they are added to the national heart transplantation waiting list. Frailty will be evaluated again every 3 months until heart transplantation and at 3, 6, and 12 months thereafter. Depression, cognitive assessment, and quality of life also will be analyzed. The 2 primary endpoints are all-cause mortality and prevalence of frailty assessed using the Fried frailty index. Results from this study may show that frailty is frequent in patients with advanced heart failure listed for heart transplantation and is associated with a poor prognosis both before and after surgery. The findings may contribute to a better understanding of the characteristics of the optimal candidate for heart transplantation.

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Association between lifetime risk of atrial fibrillation and mortality in the oldest old

Kheirbek

Fokar

Moore

et al. 2018

Clinical Cardiology

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Centenarians and their hearts: A prospective registry with comprehensive geriatric assessment, electrocardiogram, echocardiography, and follow-up

Cited by 29 publications

References 26 publications

ECG low QRS voltage and wide QRS complex predictive of centenarian 360-day mortality

ECG low QRS voltage and wide QRS complex predictive of centenarian 360-day mortality

Rationale and design of the FELICITAR registry (Frailty Evaluation After List Inclusion, Characteristics and Influence on Transplantation and Results)

Association between lifetime risk of atrial fibrillation and mortality in the oldest old

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