Centaurium erythrea (Gentianaceae) leaf extract alleviates streptozotocin-induced oxidative stress and β-cell damage in rat pancreas

Sefi, Mediha; Fetoui, Hamadi; Lachkar, Nadya; Tahraoui, Adel; Lyoussi, Badiaâ; Boudawara, Tahia; Zeghal, Najiba

doi:10.1016/j.jep.2011.02.029

Cited by 69 publications

(32 citation statements)

References 52 publications

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“…Traditional knowledge and historic literatures on ethnomedicine provide another aspect of clues for discovering potential therapeutic agents (Yamabe et al, 2010;Sefi et al, 2011;Sunil et al, 2011). Entada phaseoloides (L.) Merr.…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic effect of total saponins from Entada phaseoloides (L.) Merr. in type 2 diabetic rats

Zheng

Gao

Yang

et al. 2012

Journal of Ethnopharmacology

137

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Section: Introductionmentioning

confidence: 99%

Antidiabetic effect of total saponins from Entada phaseoloides (L.) Merr. in type 2 diabetic rats

Zheng

Gao

Yang

et al. 2012

Journal of Ethnopharmacology

137

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“…High xanthone and flavonoid content resulted in significant anti-radical activity in C. erythraea extracts (Sefi et al 2011;Š iler et al 2014). This study provides the first assessment of TPC and ARA in different C. erythraea in vitro cultures with cell suspension culture exhibiting similar amount of TPC and significantly higher ARA than wild plants, even though in vitro shoot and callus cultures contained significantly lower TPC (Fig.…”

Section: Resultsmentioning

confidence: 79%

In vitro culture type and elicitation affects secoiridoid and xanthone LC–ESI–TOF MS profile and production in Centaurium erythraea

Boroduske

Nakurte

Tomsone

et al. 2016

Plant Cell Tiss Organ Cult

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Centaurium erythraea is medicinal plant with high content of secoiridoid glycosides and xanthones with gastroprotective, hepatoprotective and antioxidative properties. In vitro culture based C. erythraea production would offer sustainable and economically feasible alternative to wild plant harvest provided that comparable productivity could be achieved in artificially propagated plants. To identify most productive C. erythraea system the secoiridoid glycoside and xanthone production and profiles using liquid chromatography-mass spectrometry were assessed in in vitro shoot, callus and cell suspension culture-derived material in comparison with wild C. erythraea plants.In vitro shoot culture was the most productive system for C. erythraea secoiridoid production (total yield 86 mg g -1 dw) and cell culture was the most productive system for phenolic compound production (19 mg GAE g -1 dw). The effect of elicitors yeast extract, methyljasmonate (MeJA) and chitosan on secondary metabolite yield indicated that elicitation with MeJA and chitosan significantly decreased yield of sweroside and eustomin, respectively. Significant quantitative differences of major secoiridoids and xanthones indicated that further methodological improvements for increasing yield of major secondary metabolites of in vitro origin need to be explored for in vitro cultivation to become a feasible alternative to C. erythraea wild plant harvest.

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“…Various phytochemicals, such as polyphenols and flavonoids were found in both in vitro and in vivo studies to exhibit anti-inflammatory and antioxidant effects activities. 11,13 Medicinal plants have attracted huge attention due to their diverse range of biological and therapeutic properties. Evidence has accumulated to demonstrate the promising potential of medicinal plants used in various traditional, complementary, and alternative systems.…”

Section: Introductionmentioning

confidence: 99%

“…In general, antioxidantsare grouped into, primary antioxidants which function as scavenger for radical species, or secondary antioxidants which function as peroxide decomposers, metal chelators, oxidative enzyme inhibitors or UV radiation absorbers. 13 The body produces enzymes such as glutathione peroxidase, glutathione reductase, catalase and superoxide dismutase, and produce natural antioxidants such as melatonin, thiol antioxidants, melatonin, specific metal proteins and coenzymes to reduceexcessive free radicals. Another source for the body antioxidants are from herbal-derived compounds, such as polyphenols, carotenoids, vitamin E, vitamin C, and trace elements.…”

mentioning

confidence: 99%

In vitro evaluation of anti-inflammatory and antioxidant effects of Asparagus aphyllus L., Crataegus azarolus L., and Ephedra alata Decne.in monocultures and co-cultures of HepG2 and THP-1-derived macrophages

Kmail¹,

Lyoussi²,

Zaid³

et al. 2017

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Introduction: Asparagus aphyllus L.,Crataegus azarolus L., and Ephedra alata Decne.have been used in traditional Greco-Arab herbal medicine to treat various metabolic and inflammatory diseases. However, to our knowledge, no scientific evidences regarding their anti-inflammatory effects have been published yet.This study aimedto evaluate the antioxidant and anti-inflammatory properties of Asparagus aphyllus L., Crataegus azarolus L., and Ephedra alata Decne.extracts using in vitro mono and co-culture systems. Methods: In the first phase of the current study we measured the total phenol, flavones and flavonol contents as well as the antioxidant activity using the DPPH scavenging assay, ABTS assay, and reducing power of the three plant extracts. In second phase, we used THP-1-derived macrophages as a monoculture and co-culture with hepatic cell line (HepG2) to assess the effects of the three plant extracts on the production of LPSinduced pro-inflammatory (IL-6 and TNF -) and anti-inflammatory (IL-10) cytokines.Results: All three extracts exhibit relatively high levels of phenolics, flavones and flavonols, which correlate with their antioxidant capacities.All three extracts were found to modulate the secretion levels of TNF -, IL-6 and IL-10 at non-toxic concentrations as measured with MTT and LDH assays. Conclusion: Taken together, our results suggest that the traditional uses of these extracts as anti-inflammatory remedies may be mediated by their significant antioxidant capacity, inhibition of pro-inflammatory cytokines secretion concomitant with enhancement of anti-inflammatory cytokines secretion.Key words: Anti-inflammatory, Antioxidant; Asparagus aphyllus L.; Crataegus azarolus L.;Ephedra alata Decne. INTRODUCTIONInflammation is the first response of the immune system to infection, irritation, as well as to various other diseases such as cancer, cardiovascular diseases, obesity, hypertension, diabetes, autoimmune, and neurodegenerative disorders.1 it involves directed migration and activation of leukocytes (neutrophils, monocytes and eosinophils) to the site of damage. Inflammation is linked to oxidant/antioxidant imbalance (an elevation in the reactive oxygen speciesin parallel to low levels of antioxidants). High levels of inflammatory markers and low level of antioxidants are observed in many inflammatory diseases 2,3 as well as in many pathological conditions such as malignancy, cardiovascular disease, diabetes type 2, kidney malfunction, gastrointestinal disorders, microbial infection, fibrogenesis, and neurological diseases. The imbalance between production of antioxidants versus getting rid of free radical species leads to oxidative stress. [4][5][6] Inflammation is driven by the release of a wide range of pro-inflammatory mediators, such as the pro-inflammatory cytokines IL-1β, IL-TNF-α, IL-6, IL 8, and IFN-γ. Anti-inflammatory cytokines that includes IL-1 receptor antagonist, IL-4, IL-6, IL-10, IL-11, and IL-13 down regulate the inflammatory response. Chemo-therapeutic anti-inflammatory dr...

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Centaurium erythrea (Gentianaceae) leaf extract alleviates streptozotocin-induced oxidative stress and β-cell damage in rat pancreas

Cited by 69 publications

References 52 publications

Antidiabetic effect of total saponins from Entada phaseoloides (L.) Merr. in type 2 diabetic rats

Antidiabetic effect of total saponins from Entada phaseoloides (L.) Merr. in type 2 diabetic rats

In vitro culture type and elicitation affects secoiridoid and xanthone LC–ESI–TOF MS profile and production in Centaurium erythraea

In vitro evaluation of anti-inflammatory and antioxidant effects of Asparagus aphyllus L., Crataegus azarolus L., and Ephedra alata Decne.in monocultures and co-cultures of HepG2 and THP-1-derived macrophages

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