Centaurium erythraea methanol extract protects red blood cells from oxidative damage in streptozotocin-induced diabetic rats

Centaurium erythraea extract reduces redox imbalance and improves insulin expression and secretion in pancreatic β-cells exposed to oxidative and nitrosative stress

“…Studies on the animal model of diabetes have revealed the antidiabetic and antioxidant effects of extracts pre- pared from CE, supporting its traditional use in diabetes management and stimulating further investigation of its biological activities [14,15,26,27]. Medicinal plants are a valuable source for drug discovery, and a number of active components have been isolated for direct use as drugs, or as a lead compound or pharmacological agent [28,29].…”

“…Suppression of the detrimental effects of H 2 O 2 and SNP by CEe could be because of the H 2 O 2 -and NOscavenging activities [14]. The CEe used in this study was previously phytochemically characterized and its free radical scavenging activity was attributed to major phenolic compounds quantified, such as quercetin, isoquercitrin, naringenin, astragalin, luteolin, apigenin, caffeic, p-coumaric, ferulic and sinapic acids and xanthones [14].…”

“…Suppression of the detrimental effects of H 2 O 2 and SNP by CEe could be because of the H 2 O 2 -and NOscavenging activities [14]. The CEe used in this study was previously phytochemically characterized and its free radical scavenging activity was attributed to major phenolic compounds quantified, such as quercetin, isoquercitrin, naringenin, astragalin, luteolin, apigenin, caffeic, p-coumaric, ferulic and sinapic acids and xanthones [14]. The mechanism involved in the scavenging activity of polyphenolic compounds includes the availability of their hydrogen atom and the possibility of stabilization of • OH and NO • through hydrogen donation or expansion of electron delocalization [40].…”

“…Procedures for the collection of plant material, preparation and phytochemical characterization of the methanol CEe used in the present study were described previously [14].…”

“…Centaurium erythraea Rafn (CE), also known as a common centaury, is a plant from the Gentianaceae family, which is used in Serbian traditional medicine for treating different diseases, including diabetes [13]. We previously presented the phytochemical characterization of the extract prepared from CE (CEe), with secoiridoid glycosides and phenolics (including xanthones and flavonoids) as its major components [14]. We demonstrated a significant in vitro antioxidant potential of CEe, including strong H 2 O 2 -and NO-scavenging activities, as well as the ability to improve the structural and functional properties of pancreatic islets in streptozotocin (STZ)induced diabetic rats [14,15].…”