CENP‐50 is required for papilloma development in the two‐stage skin carcinogenesis model

Saito, Megumi; Kagawa, Naoko; Okumura, Kazuhiro; Munakata, Haruka; Isogai, Emiko; Fukagawa, Tatsuo; Wakabayashi, Yuichi

doi:10.1111/cas.14533

Cited by 2 publications

(2 citation statements)

References 37 publications

(77 reference statements)

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“…A few studies have linked these proteins with tumors. One study indicated that CENPU was essential for papilloma development in a skin carcinogenesis model (33). In the current study, we found that CENPU was significantly upregulated in the tumor tissues of patients with LUAD.…”

Section: Discussionsupporting

confidence: 62%

A five-gene expression signature of centromeric proteins with prognostic value in lung adenocarcinoma

Wang¹,

Chen²,

Meng³

et al. 2023

Transl Cancer Res

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Background: Centromere proteins (CENPs) form a large protein family. Sixteen proteins in this family are positioned at the centromere throughout the cell cycle. The overexpression of CENPs is common in many cancers and predicts a poor prognosis. However, a comprehensive analysis of CENPs expression has not been conducted, and their clinical significance in lung adenocarcinoma (LUAD) is unclear.Methods: We investigated the expression differences of the CENP family in LUAD using The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) cohorts. Kaplan-Meier curve survival analysis was performed to assess their independent prognostic values. We then tested 5 clinical LUAD specimens by quantitative real time polymerase chain reaction (qRT-PCR). The risk model was constructed with least absolute shrinkage and selection operator (LASSO). Cox regression analyses were carried out to determine independent prognostic indicators. Weighted gene coexpression network analysis (WGCNA) was employed to define the coexpression networks. Results:The messenger RNA (mRNA) expression of 15 differential CENP proteins was higher in LUAD than in normal lung tissues. Among them, 10 CENP proteins had significant prognostic value. The risk model comprising CENPF, CENPU, CENPM, CENPH, and CENPW showed a significant correlation [hazard ratio (HR) 1.75, 95% confidence interval (CI): 1.3-2.35; P=2e−04]. However, the prognostic accuracy was not strong [1-year survival: area under curve (AUC) 0.63; 3-year survival: AUC 0.62; 5-year survival: AUC 0.6]. The qRT-PCR results showed that the 5 CENPs were upregulated in LUAD tissues compared to in normal lung tissues. A total of 441 hub genes coexpressed with the 5 CENPs were identified.Conclusions: CENPF, CENPU, CENPM, CENPH, and CENPW have prognostic values and may be potential targets for LUAD treatment.

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Section: Discussionsupporting

confidence: 62%

A five-gene expression signature of centromeric proteins with prognostic value in lung adenocarcinoma

Wang¹,

Chen²,

Meng³

et al. 2023

Transl Cancer Res

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“…The role of various genes and cellular signaling pathways involved in developing skin tumors can be investigated in this two-stage skin carcinogenesis model by using a genetically engineered mouse model [ 10 ]. Genetically modified mice have been used to analyze various genes (i.e., oncogenic transcription factors, constitutive centromere-related network proteins) [ 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

A wild-derived inbred mouse strain, MSM/Ms, provides insights into novel skin tumor susceptibility genes

2021

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Cancer is one of the most catastrophic human genetic diseases. Experimental animal cancer models are essential for gaining insights into the complex interactions of different cells and genes in tumor initiation, promotion, and progression. Mouse models have been extensively used to analyze the genetic basis of cancer susceptibility. They have led to the identification of multiple loci that confer, either alone or in specific combinations, an increased susceptibility to cancer, some of which have direct translatability to human cancer. Additionally, wild-derived inbred mouse strains are an advantageous reservoir of novel genetic polymorphisms of cancer susceptibility genes, because of the evolutionary divergence between wild and classical inbred strains. Here, we review mapped Stmm ( skin t umor m odifier of M SM) loci using a Japanese wild-derived inbred mouse strain, MSM/Ms, and describe recent advances in our knowledge of the genes responsible for Stmm loci in the 7,12-dimethylbenz(a)anthracene (DMBA)/12- O -tetradecanoylphorbol-13-acetate (TPA) two-stage skin carcinogenesis model.

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CENP‐50 is required for papilloma development in the two‐stage skin carcinogenesis model

Cited by 2 publications

References 37 publications

A five-gene expression signature of centromeric proteins with prognostic value in lung adenocarcinoma

A five-gene expression signature of centromeric proteins with prognostic value in lung adenocarcinoma

A wild-derived inbred mouse strain, MSM/Ms, provides insights into novel skin tumor susceptibility genes

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