Cemento-ossifying fibroma and juvenile ossifying fibroma: Clarity in terminology

Desai, Rajiv S.; Bansal, Shivani; Shirsat, Pankaj M; Prasad, Pooja; Sattar, Shumail

doi:10.1016/j.oraloncology.2020.105050

Cited by 8 publications

(16 citation statements)

References 2 publications

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“…JPOF can occur in adults but patients are nevertheless significantly younger than those described here (mean 44 years). COF typically shows rimming of activated osteoblasts and occasionally a matrix-free rim at the periphery separating the lesion from preexisting bone, neither of which was observed in the current cases [3,12]. COD typically is centered around the teeth roots and in the majority of cases lacks an expansile growth, a finding distinctly different from the presented cases.…”

Section: Discussioncontrasting

confidence: 58%

“…As long as no additional molecular data suggests the cases from our series to belong to a separate fibro-osseous subtype, we propose to broaden the criteria defining ossifying fibroma and to consider revising the name from cemento-ossifying fibroma to conventional ossifying fibroma comprising odontogenic and non-odontogenic subtypes. However, this opinion is not shared by other authors who recently proposed to more strictly separate COF as an odontogenic neoplasm from the juvenile, non-odontogenic subtypes of OF [3]. Alternatively, a new category of ossifying fibroma of non-odontogenic origin might be required.…”

Section: Discussionmentioning

confidence: 89%

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Ossifying Fibroma of Non-odontogenic Origin: A Fibro-osseous Lesion in the Craniofacial Skeleton to be (Re-)considered

Baumhoer

Haefliger

Ameline

et al. 2021

Head and Neck Pathol

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In the cranio-facial skeleton, a heterogeneous group of well characterized fibro-osseous lesions can be distinguished. Whereas fibrous dysplasia can affect any skeletal bone, ossifying fibroma and cemento-osseous dysplasia exclusively develop in the cranio-facial region, with most subtypes restricted to the tooth bearing areas of the jaws. Herein we present a series of 20 fibro-osseous lesions that developed mostly in the frontal bone and in the mandible, presenting as expansile intramedullary tumors with a unique histologic appearance and an indolent clinical course. We provide evidence that these tumors are distinct from the categories included in the WHO classification and are therefore currently unclassifiable. The definition of cemento-ossifying fibroma as an odontogenic neoplasm developing only in close proximity to teeth should be re-considered and incorporate also extragnathic lesions as shown here.

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Section: Discussioncontrasting

confidence: 58%

Section: Discussionmentioning

confidence: 89%

Ossifying Fibroma of Non-odontogenic Origin: A Fibro-osseous Lesion in the Craniofacial Skeleton to be (Re-)considered

Baumhoer

Haefliger

Ameline

et al. 2021

Head and Neck Pathol

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“…It is considered a distinct condition from the cemento-ossifying fibroma (COF), because of its non-odontogenic origin and particular clinicopathological features. 1,2 In addition, JOF presents a peculiar clinical behavior, with two clinicopathological variants: trabecular JOF (TJOF) and psammomatoid JOF (PJOF). 1,2 While TJOF is more common in the maxilla of individuals up to 12 years of age, available clinical data demonstrate that PJOF can occur not only in young people but in individuals ranging from 3 months to 72 years old.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 In addition, JOF presents a peculiar clinical behavior, with two clinicopathological variants: trabecular JOF (TJOF) and psammomatoid JOF (PJOF). 1,2 While TJOF is more common in the maxilla of individuals up to 12 years of age, available clinical data demonstrate that PJOF can occur not only in young people but in individuals ranging from 3 months to 72 years old. 3 PJOF have no sex predominance and mainly affects extragnathic sites, especially the paranasal sinuses, periorbital bones, and skull base.…”

Section: Introductionmentioning

confidence: 99%

“…3 Microscopically, the TJOF shows a mineralized component composed of highly cellular osteoid, rich in osteoblastic paving, bulky osteoblasts and multinucleated osteoclasts. 1,2 The term psammomatoid, which is used in the PJOF, refers to the calcified, lamellar, concentric, acellular, and basophilic structures commonly observed microscopically. 4 These structures resemble the psammoma bodies found in papillary thyroid carcinoma, meningioma, and other neoplastic conditions.…”

Section: Introductionmentioning

confidence: 99%

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Psammomatoid juvenile ossifying fibroma of frontal sinus surgical and reconstructive approach

Tenório¹,

Bártholo²,

Romañach³

et al. 2022

Autops Case Rep

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Psammomatoid juvenile ossifying fibroma (PJOF) is a benign fibro-osseous lesion that mainly affects the paranasal sinuses and periorbital bones. It may cause significant esthetic and functional impairment. Herein, we describe the diagnosis and surgical approach of an extensive PJOF arising in the frontal sinus of a young male. After complete lesion removal and histopathological confirmation, the bone defect was repaired with a customized polymethylmethacrylate implant. PJOF may present aggressive clinical behavior. The excision of extensive PJOF in the orbitofrontal area can result in significant esthetic defects. Polymethacrylate implants restore functionally and esthetically the involved area.

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A Clinical, Radiological and Histopathological Review of 74 Ossifying Fibromas

Collins

Zegalie

Sassoon

et al. 2023

Head and Neck Pathol

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Background Ossifying fibroma (OF) is a fibro-osseous lesion of the jaws and craniofacial bones. Accurate diagnosis can be challenging due to significant overlap of clinicopathological features. This study aimed to evaluate the clinical, radiological and histological features that can aid in diagnosis and identify characteristics that allow categorisation into the three subtypes: juvenile trabecular, psammomatoid and cemento-ossifying OF. Methods A total of 74 cases of OF were systematically reviewed for their principle features. Of these, 46 cases were evaluated for their radiographic features including size, location and relationship to the teeth. Histological assessment and stereological point counting were performed in 69 cases to assess the pattern, type and proportion of calcification, the nature of the stroma, the border of the lesion and the presence of secondary changes. Fisher’s exact test and Chi-squared tests were used to determine associations between clinicopathological parameters and maxillary, mandibular, odontogenic, non-odontogenic and psammomatoid or trabecular lesions. Results OF showed a female predilection (F: M; 2:1) and a slight bimodal age distribution with peaks in the second (23%) and fourth decades (27%) (Mean age: 32.4 years). 83% of cases presented as an intra-oral swelling, with the mandible being the most common site (73%). Histologically, a range of morphological patterns were seen, with 50% of cases showing mixed trabecular and psammomatoid features. However, there were no significant differences between the variants of OF in terms of age, gender or histological features. Conclusion Histological features of OF cannot be used to differentiate between the subtypes.

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Cemento-ossifying fibroma and juvenile ossifying fibroma: Clarity in terminology

Cited by 8 publications

References 2 publications

Ossifying Fibroma of Non-odontogenic Origin: A Fibro-osseous Lesion in the Craniofacial Skeleton to be (Re-)considered

Ossifying Fibroma of Non-odontogenic Origin: A Fibro-osseous Lesion in the Craniofacial Skeleton to be (Re-)considered

Psammomatoid juvenile ossifying fibroma of frontal sinus surgical and reconstructive approach

A Clinical, Radiological and Histopathological Review of 74 Ossifying Fibromas

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