Cembranoid Diterpenes from the Soft Coral &lt;i&gt;Lobophytum crassum&lt;/i&gt; and Their Anti-inflammatory Activities

Cuong, Nguyen Xuan; Thảo, Nguyễn Phương; Luyen, Bui Thi Thuy; Ngân, Nguyễn Thị Thanh; Thuy, Dinh Thi Thu; Song, Seung‐Wan; Nam, Nguyen Hoai; Kiệm, Phan Văn; Kim, Young Ho; Minh, Châu Văn

doi:10.1248/cpb.c13-00805

Cited by 20 publications

(22 citation statements)

References 12 publications

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“…Inflammation plays a crucial role in many physio/pathological states, and different cell populations are involved in all phases of inflammatory process, including neutrophils, dendritic cells, monocytes/macrophages, and lymphocytes. Previous findings suggested that marine diterpenoids elicit among numerous activities, anti-inflammatory effects on murine macrophages [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 47 , 53 ]. In this study, starting from a previous drug discovery study aimed to fractionate marine samples, we successfully demonstrated that the sponge metabolite DHG possesses promising anti-inflammatory properties in vitro and in vivo.…”

Section: Discussionmentioning

confidence: 99%

“…Cembranoids such as gibberosenes, grandilobatin, sarcocrassocolides, querciformolides, crassarines, crassumolides, sinularolides, durumolides and columnariols have shown capacity to block the expression of iNOS and/or COX-2 by LPS-activated RAW264.7 cells [ 34 ]. Some cembranoids have been identified as modulators of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway [ 35 , 36 , 37 ]. Indeed, in recent years, anti-inflammatory activity for eunicellin-based diterpenoids isolated from soft corals, has been described [ 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

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Immuno-Modulatory and Anti-Inflammatory Effects of Dihydrogracilin A, a Terpene Derived from the Marine Sponge Dendrilla membranosa

Ciaglia

Malfitano

Laezza

et al. 2017

IJMS

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We assessed the immunomodulatory and anti-inflammatory effects of 9,11-dihydrogracilin A (DHG), a molecule derived from the Antarctic marine sponge Dendrilla membranosa. We used in vitro and in vivo approaches to establish DHG properties. Human peripheral blood mononuclear cells (PBMC) and human keratinocytes cell line (HaCaT cells) were used as in vitro system, whereas a model of murine cutaneous irritation was adopted for in vivo studies. We observed that DHG reduces dose dependently the proliferative response and viability of mitogen stimulated PBMC. In addition, DHG induces apoptosis as revealed by AnnexinV staining and downregulates the phosphorylation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), signal transducer and activator of transcription (STAT) and extracellular signal–regulated kinase (ERK) at late time points. These effects were accompanied by down-regulation of interleukin 6 (IL-6) production, slight decrease of IL-10 and no inhibition of tumor necrosis factor-alpha (TNF-α) secretion. To assess potential properties of DHG in epidermal inflammation we used HaCaT cells; this compound reduces cell growth, viability and migration. Finally, we adopted for the in vivo study the croton oil-induced ear dermatitis murine model of inflammation. Of note, topical use of DHG significantly decreased mouse ear edema. These results suggest that DHG exerts anti-inflammatory effects and its anti-edema activity in vivo strongly supports its potential therapeutic application in inflammatory cutaneous diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Immuno-Modulatory and Anti-Inflammatory Effects of Dihydrogracilin A, a Terpene Derived from the Marine Sponge Dendrilla membranosa

Ciaglia

Malfitano

Laezza

et al. 2017

IJMS

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“…Further investigation of this genus revealed more than 250 compounds categorized into cembrane-type diterpenoids [2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58], other types of diterpenoids [59,60,61,62,63,64,65], lipids […”

Section: Introductionmentioning

confidence: 99%

“…Their effect was evaluated on iNOS (inducible nitric oxide synthase) [10,13], COX-2 (cyclooxygenase-2) [10,19], NF- κ B (nuclear factor kappa-light-chain-enhancer of activated B cells) [19,20], and neutrophil elastase release [15,18], as well as superoxide anion [15] and NO reduction [12,23]. Additionally, these compounds showed potent antiviral [31,49] and anti-bacterial activities [40,43], as well as brine shrimp [45] and fish toxicity [45].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Cembranoids from the Soft Coral Lobophytum crassum

et al. 2017

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Cembrane-type diterpenoids are among the most frequently encountered natural products from the soft corals of the genus Lobophytum. In the course of our investigation to identify anti-inflammatory constituents from a wild-type soft coral Lobophytum crassum, two new cembranoids, lobophyolide A (1) and B (2), along with five known compounds (3–7), were isolated. The structures of these natural products were identified using NMR and MS spectroscopic analyses. Compound 1 was found to possess the first identified α-epoxylactone group among all cembrane-type diterpenoids. The in vitro anti-inflammatory effect of compounds 1–5 was evaluated. The results showed that compounds 1–5 not only reduced IL-12 release, but also attenuated NO production in LPS-activated dendritic cells. Our data indicated that the isolated series of cembrane-type diterpenoids demonstrated interesting structural features and anti-inflammatory activity which could be further developed into therapeutic entities.

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“…Natural products are alternatives to these drugs and offer hope for discovering bioactive lead compounds that may be developed into drugs for treatment of inflammatory disorders [12]. Plenty of unique marine natural products and their derivatives, such as sesquiterpenoid, polysaccharide, steroid/sterol and alkaloid, are found to manifest an anti-inflammatory action [13,14,15,16,17,18]. …”

Section: Introductionmentioning

confidence: 99%

Macrolactins from Marine-Derived Bacillus subtilis B5 Bacteria as Inhibitors of Inducible Nitric Oxide and Cytokines Expression

et al. 2016

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In order to find new natural products with anti-inflammatory activity, chemical investigation of a 3000-meter deep-sea sediment derived bacteria Bacillus subtilis B5 was carried out. A new macrolactin derivative was isolated and identified as 7,13-epoxyl-macrolactin A (1). Owing to the existence of the epoxy ring, 1 exhibited a significant inhibitory effect on the expression of inducible nitric oxide and cytokines, compared with previously isolated known macrolactins (2–5). Real-time Polymerase Chain Reaction (PCR) analysis showed that the new compound significantly inhibited the mRNA expressions of inducible nitric oxide synthase (iNOS), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Reverse transcription-PCR analysis demonstrated that the new compound reduced the mRNA expression level of IL-1β in a concentration-dependent manner.

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Cembranoid Diterpenes from the Soft Coral <i>Lobophytum crassum</i> and Their Anti-inflammatory Activities

Cited by 20 publications

References 12 publications

Immuno-Modulatory and Anti-Inflammatory Effects of Dihydrogracilin A, a Terpene Derived from the Marine Sponge Dendrilla membranosa

Immuno-Modulatory and Anti-Inflammatory Effects of Dihydrogracilin A, a Terpene Derived from the Marine Sponge Dendrilla membranosa

Anti-Inflammatory Cembranoids from the Soft Coral Lobophytum crassum

Macrolactins from Marine-Derived Bacillus subtilis B5 Bacteria as Inhibitors of Inducible Nitric Oxide and Cytokines Expression

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