Cembrane diterpenoids from the Taiwanese soft coral Sinularia flexibilis

Lin, Yun‐Sheng; Chen, Chung‐Hsiung; Liaw, Chia‐Ching; Chen, Yu‐Chen; Kuo, Yao‐Haur; Shen, Ya‐Ching

doi:10.1016/j.tet.2009.09.031

Cited by 63 publications

(36 citation statements)

References 26 publications

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“…We recently reported six new cembranoids querciformolides A-D and granosolides A and B, along with two known metabolites from the soft coral Sinularia querciformis and S. granosa. 7) In continuation of our search for bioactive metabolites from the above two soft corals, we have further isolated eight metabolites including three new cembranoids, granosolides C and D (1, 2) and querciformolide E (3), along with four known metabolites, flexibilisolide A (4), 8) flexilarin (5), 9) sinulariolide (6) 10) and sinulaflexiolide E (7).…”

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confidence: 99%

Cembranoids from the Soft Corals Sinularia granosa and Sinularia querciformis

Huang

et al. 2010

CHEMICAL & PHARMACEUTICAL BULLETIN

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Two new cembranoids, namely granosolides C (1) and D (2), along with one known cembranoid 4, were isolated from the soft coral Sinularia granosa. Chemical investigation of Sinularia querciformis also afforded one new cembranoid, querciformolide E (3), along with four known cembranoids 4-7. The structures of these compounds were elucidated on the basis of their spectroscopic data. Both 4 and 5 were shown to significantly inhibit the accumulation of the pro-inflammatory inducible nitric oxide synthase protein in lipopolysaccharide-stimulated RAW264.7 macrophage cells.

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confidence: 99%

Cembranoids from the Soft Corals Sinularia granosa and Sinularia querciformis

Huang

et al. 2010

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Sinularia grandilobata didapati senyawa Sinugrandisterols A-D, trihydroxysteroids (Ahmed et al, 2007). Sinularia flexibilis ditemukan senyawa cembrane diterpenoids (Lin et al, 2009). Lobophytum sarcophytoides ditemukan steroid dan cembranoid (Lu et al, 2010).…”

Section: Pendahuluanunclassified

Screening on the Potential Bioactive Compounds of Antibacterial Activity in Soft Coral Collected From South Bangka Island Waters and Lampung Bay

Rozirwan¹,

Bengen²,

Zamani³

et al. 2015

J. Ilmu dan Teknologi Kelautan Tropis

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Soft corals contain bioactive compounds that can be used as a marine natural product. The puposes of this study was to determine of the soft corals inhibitionKeywords: bioactive compounds, Lobophytum, Nephthea, Sarcophyton, Sinularia, soft coral ABSTRAK Karang lunak telah diketahui mengandung senyawa bioaktif yang dapat dijadikan sebagai marine natural produk. Penelitian ini bertujuan untuk menentukan jenis-jenis karang lunak yang memiliki potensi senyawa bioaktif sebagai antibakteri. Metode yang dilakukan meliputi pengumpulan sampel karang lunak yang diambil dari dua perairan Bangka Selatan dan Teluk Lampung, ekstraksi sampel (dengan pelarut n-Hex, EtOAc dan MeOH), dan pengujian aktivitas antibakteri serta identifikasi spesies target penelitian. Hasil dari penanganan sampel menunjukkan bahwa biomassa sampel basah sampai kering cukup bervariasi, selisih penyusutan tertinggi adalah pada sampel genus Nephthea, Lobophytum, Sarcophyton, dan Sinularia. Hasil ekstraksi dari 12 sampel karang lunak diperoleh nilai berat ekstrak terendah pada pelarut semipolar (EtOAc), sedangkan berat ekstrak dalam n-Hex dan MeOH bervariasi. Daya hambat antibakteri dari keseluruhan ekstrak sampel ditunjukkan pada ekstrak karang lunak dalam pelarut EtOAc dan sebagian ekstrak dalam pelarut MeOH. Nilai daya hambat tertinggi ditunjukkan pada karang lunak spesies Sinularia polydactyla dan S. flexibilis dengan kategori kuat.

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“…Dendronpholides C (171), and J (176) showed a selective and significant inhibition against BGC-823 (IC 50 = 0.05, 0.20 μg/mL, respectively) [65,66]. The soft coral Sinularia flexibilis produced an abundance of cembranoids, including flexibilisin A (186), and flexibilisin B (187) [67], sinulaflexiolides E-H (188-191) [43], sinuflexibilin (192) [68], sinuladiterpene I (193) [69], flexilarins B, and C (194, 195) [70]. Sinulaflexiolide E showed selective inhibitory activity against the gastric gland carcinoma cell line BGC-823 at 0.12 μM [43].…”

Section: Isopropyl/ Isopropenyl Acid Cembranesmentioning

confidence: 99%

“…Two cembranolides, sinularin (394), and dihydrosinularin (395) were isolated from the soft coral Sinularia flexibilis from Hayman island on the Great Barrier Reef of Australia [118]. Flexilarins A (396), was isolated from the same species, collected from the southern coast of Taiwan [70]. Chemical investigations of the soft coral Lobophytum durum have led to the isolation of three unprecedented hemiketal cembranolides, durumhemiketalolides A-C (397-399).…”

Section: -Membered Lactonementioning

confidence: 99%

“…Chromatographic investigation of the octocoral Sinularia flexibilis afforded eight new diterpenes, sinuladiterpenes A-H (406-413), Compound 407 exhibited in vitro cytotoxic activity against human colon adenocarcinoma (WiDr) cell line with ED 50 8.37 μg/ml [69,121]. Moreover, a series of analogs were also isolated from Sinularia flexibilis, including sinulaflexiolides B-D, J, and K (414-418) [43], flexilarins D-J (419-425) [70], sinulariolone (426) [122], sandensolide monoacetate (427) and flexibolide (428) [123], and sinulariolide (429) [124]. Sinulaflexiolides D (416) showed selective inhibitory activity against the gastric gland carcinoma cell line BGC-823 at 8.5 μM.…”

Section: -Membered Lactonementioning

confidence: 99%

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Cembrane Diterpenes Chemistry and Biological Properties

Yang¹,

Zhou²,

Lin³

et al. 2012

COC

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Cembrane-type diterpenoids are a large and structurally varied group of natural products isolated from both terrestrial and marine organisms. The present paper reviews all the metabolites of cembrane diterpenes, reported up to 2010. The natural products discussed in this review can be divided into several different structural families featuring a variety of ring sizes and oxidation patterns. The currently known biological activities will be presented as well.

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Cembrane diterpenoids from the Taiwanese soft coral Sinularia flexibilis

Cited by 63 publications

References 26 publications

Cembranoids from the Soft Corals Sinularia granosa and Sinularia querciformis

Cembranoids from the Soft Corals Sinularia granosa and Sinularia querciformis

Screening on the Potential Bioactive Compounds of Antibacterial Activity in Soft Coral Collected From South Bangka Island Waters and Lampung Bay

Cembrane Diterpenes Chemistry and Biological Properties

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