Celulitis necrotizante como primera manifestación de una criptococosis diseminada

Bordel-Gómez, M.T.; Zafra-Cobo, M.I.; Cardeñoso-Álvarez, M.E.; Sánchez-Estella, J.; Martín-Arribas, M.I.

doi:10.1016/j.ad.2010.08.004

Cited by 3 publications

(2 citation statements)

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“…La principal puerta de entrada del agente infeccioso es la vía respiratoria. En los pacientes inmunocompetentes, habitualmente la infección se limita a esta localización, desarrollando, en algún caso, una sintomatología y una traducción radiológica escasa con resolución espontánea [1][2][3].…”

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Paniculitis como primera manifestacion de una criptococosis diseminada

Rotela¹,

Agüero²,

Ortíz³

et al. 2017

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Cryptococcosis is an opportunistic fungal infection caused by Cryptococcus neoformans. Encapsulated yeast worldwide distribution, related to pigeon droppings, its main entrance is inhaled. Asymptomatic in immunocompetent, but produces exceptionally pneumonitis and a skin primoinfection. In immunocompromised individuals, it spreads through the blood mainly affecting the central nervous system, skin and bones. We report the case of a 23-year-old woman, veterinary student, chronic insufficient kidney by diffuse glomerulosclerosis of unknown etiology for 2 years, Hypertension and anemia of chronic diseases treated with prednisone, cyclophosphamide boluses monthly, and triweekly hemodialysis; with violet-erythematous nodules on legs and right arm, showing oval birefringent structures, intracytoplasmic PAS positive, yeast, encapsulated, surrounded by a clear halo around a core biopsy of hypodermis, and skin culture positive for Cryptococcus neoformans. Treatment was established with fluconazole 400 mg/d for two weeks, then 200mg/d as crops, with a resolution of skin lesions. Not detected until 12 months of follow-up by Cryptococcus neoformans invasion in other organs.

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“…El sistema nervioso central es, tras los pulmones, el segundo órgano afectado en frecuencia, las manifestaciones clínicas son variables y dependen del perfil del paciente [1].…”

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