Células madre en el tratamiento de la sordera

Pellicer, Marc; Giráldez, Fernando; Pumarola, M.; Barquinero, J

doi:10.1016/s0001-6519(05)78606-4

Cited by 9 publications

(2 citation statements)

References 64 publications

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“…And Parker et al in 2004 studied the potential use of stem cells for cochlear repair ( 23 , 24 ). Also many other stem cell studies have done in the next few years between 2003 and 2010 but most of these studies concentrated on the transplantation of stem cells into damaged inner ear or in vitro studies for generating hair cells from stem cells of different origins ( 25 , 26 ).…”

Section: Discussionmentioning

confidence: 99%

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Role of Endogenous Bone Marrow Stem Cells Mobilization in Repair of Damaged Inner Ear in Rats

Elbana

Abdel-Salam

Morad

et al. 2015

IJSC

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Background and ObjectivesThe utilization of the stem cells is widely used in the last few years in different fields of medicine, either by external transplantation or endogenous mobilization, most of these studies still experimental on animals; few were tried on human as in the spinal cord injury or myocardial infarction. As regard its use in the inner ear, stem cell transplantation was examined in many previous studies, while the mobilization idea is a new method to be experimented in inner ear hair cell regeneration. The present work assessed the possibility of mobilizing endogenous bone marrow derived stem cells (SCs) in rats using granulocyte colony stimulating factor (G-CSF) to induce regeneration and repair to experimentally damaged inner ear hair cells by Amikacin injection.MethodsThe study included thirty adult Sprague Dawley male rats. Experimental induction of inner ear damage was done by repeated intratympanic injection of amikacin sulfate. Mobilization of bone marrow SCs was provoked by subcutaneous injection of GCSF. Cochlear integrity, induction of hearing loss and functional recovery of sensory hearing loss were assessed using Distortion Product Otoacoustic Emission (DPOAEs). The morphological alteration and recovery of the organ of Corti was assessed histologically using the light and scanning electron microscopes.ResultsAfter six month duration, there was improvement in 50% of the sensorineural DPOAE results. Functional recovery coincided with the repair of structural components of organ of Corti.ConclusionsSCs mobilization by G-CSF is a promising alternative method for replacement therapy in sensorineural hearing loss.

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Section: Discussionmentioning

confidence: 99%

“…From a clinical perspective, surgical and technical procedures need to be developed to successfully transplant stem cells into the inner ear. The critical question to be answered is whether transplanted stem cells can migrate to the correct location, differentiate into hair cells and restore hearing or balance ( 25 , 26 ).…”

Section: Introductionmentioning

confidence: 99%

Role of Endogenous Bone Marrow Stem Cells Mobilization in Repair of Damaged Inner Ear in Rats

Elbana

Abdel-Salam

Morad

et al. 2015

IJSC

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Transplantation of Mouse Embryonic Stem Cells into the Cochlea of an Auditory-Neuropathy Animal Model: Effects of Timing after Injury

Lang

Schulte

Goddard

et al. 2008

JARO

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Application of ouabain to the round window membrane of the gerbil selectively induces the death of most spiral ganglion neurons and thus provides an excellent model for investigating the survival and differentiation of embryonic stem cells (ESCs) introduced into the inner ear. In this study, mouse ESCs were pretreated with a neural-induction protocol and transplanted into Rosenthal's canal (RC), perilymph, or endolymph of Mongolian gerbils either 1-3 days (early post-injury transplant group) or 7 days or longer (late post-injury transplant group) after ouabain injury. Overall, ESC survival in RC and perilymphatic spaces was significantly greater in the early post-injury microenvironment as compared to the later post-injury condition. Viable clusters of ESCs within RC and perilymphatic spaces appeared to be associated with neovascularization in the early post-injury group. A small number of ESCs transplanted within RC stained for mature neuronal or glial cell markers. ESCs introduced into perilymph survived in several locations, but most differentiated into glia-like cells. ESCs transplanted into endolymph survived poorly if at all. These experiments demonstrate that there is an optimal time window for engraftment and survival of ESCs that occurs in the early post-injury period.

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Endogenous bone marrow stem cell mobilization in rats: Its potential role in homing and repair of damaged inner ear

Elbana

Abdel-Salam

Morad

et al. 2015

Egyptian Journal of Ear, Nose, Throat and Allied Sciences

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Células madre en el tratamiento de la sordera

Cited by 9 publications

References 64 publications

Role of Endogenous Bone Marrow Stem Cells Mobilization in Repair of Damaged Inner Ear in Rats

Role of Endogenous Bone Marrow Stem Cells Mobilization in Repair of Damaged Inner Ear in Rats

Transplantation of Mouse Embryonic Stem Cells into the Cochlea of an Auditory-Neuropathy Animal Model: Effects of Timing after Injury

Endogenous bone marrow stem cell mobilization in rats: Its potential role in homing and repair of damaged inner ear

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