Cellulose nanocrystals reinforced highly stretchable thermal-sensitive hydrogel with ultra-high drug loading

Chen, Tianxing; Yang, Yuan; Whittaker, Andrew K.; Li, Yao; Zhao, Qinglan; Wang, Yu; Zhu, Shenmin; Wang, Zhaoyang

doi:10.1016/j.carbpol.2021.118122

Cited by 43 publications

(28 citation statements)

References 40 publications

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“…; which may limit utilization, especially in tissue engineering application [ 166 ]. Some recent studies, e.g., silver nanoparticles/(PNIPAM166-co-n-butyl acrylate9)-poly(ethylene glycol)-(PNIPAM166-co-n-butyl acrylate9) copolymeric hydrogel [ 167 ], cellulose nanocrystals/PNIPAM hydrogel [ 168 ], fibroblast growth factor/sodium alginate (SA)/PNIPAM nanogel [ 169 ], polydopamine nanoparticles/PNIPAM hydrogel, etc. ; showed high stimuli responsiveness [ 167 ], encapsulation efficiency [ 168 ], storage modulus, and water absorption capacity [ 169 ] in tissue engineering and wound healing applications.…”

Section: Formulation Approaches For Tailoring the Mechanical Behavior...mentioning

confidence: 99%

“…Some recent studies, e.g., silver nanoparticles/(PNIPAM166-co-n-butyl acrylate9)-poly(ethylene glycol)-(PNIPAM166-co-n-butyl acrylate9) copolymeric hydrogel [ 167 ], cellulose nanocrystals/PNIPAM hydrogel [ 168 ], fibroblast growth factor/sodium alginate (SA)/PNIPAM nanogel [ 169 ], polydopamine nanoparticles/PNIPAM hydrogel, etc. ; showed high stimuli responsiveness [ 167 ], encapsulation efficiency [ 168 ], storage modulus, and water absorption capacity [ 169 ] in tissue engineering and wound healing applications. Therefore, choosing the best material to form a hybrid system with PNIPAM requires extensive materials study, which can further modulate the properties and functionalities of PNIPAM-based hydrogels in biomedical applications.…”

Section: Formulation Approaches For Tailoring the Mechanical Behavior...mentioning

confidence: 99%

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Poly(N-isopropylacrylamide)-Based Hydrogels for Biomedical Applications: A Review of the State-of-the-Art

Ansari

Rajendran

Mohanto

et al. 2022

Gels

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A prominent research topic in contemporary advanced functional materials science is the production of smart materials based on polymers that may independently adjust their physical and/or chemical characteristics when subjected to external stimuli. Smart hydrogels based on poly(N-isopropylacrylamide) (PNIPAM) demonstrate distinct thermoresponsive features close to a lower critical solution temperature (LCST) that enhance their capability in various biomedical applications such as drug delivery, tissue engineering, and wound dressings. Nevertheless, they have intrinsic shortcomings such as poor mechanical properties, limited loading capacity of actives, and poor biodegradability. Formulation of PNIPAM with diverse functional constituents to develop hydrogel composites is an efficient scheme to overcome these defects, which can significantly help for practicable application. This review reports on the latest developments in functional PNIPAM-based smart hydrogels for various biomedical applications. The first section describes the properties of PNIPAM-based hydrogels, followed by potential applications in diverse fields. Ultimately, this review summarizes the challenges and opportunities in this emerging area of research and development concerning this fascinating polymer-based system deep-rooted in chemistry and material science.

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Section: Formulation Approaches For Tailoring the Mechanical Behavior...mentioning

confidence: 99%

Section: Formulation Approaches For Tailoring the Mechanical Behavior...mentioning

confidence: 99%

Poly(N-isopropylacrylamide)-Based Hydrogels for Biomedical Applications: A Review of the State-of-the-Art

Ansari

Rajendran

Mohanto

et al. 2022

Gels

View full text Add to dashboard Cite

show abstract

“…54 In addition, the pNIPAAM hydrogel network has an ultrahigh drug loading capacity, a fast thermal responsiveness mechanism triggered by near-infrared light (NIR) and high biocompatibility. 55 In short, this multiscale delivery system is expected to be a viable strategy for regenerative IVDs.…”

Section: Temperature Sensitive Hydrogelsmentioning

confidence: 99%

Aggressive strategies for regenerating intervertebral discs: stimulus-responsive composite hydrogels from single to multiscale delivery systems

Gao

Zhang

et al. 2022

J. Mater. Chem. B

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“…Therefore, it has unique advantages in treating tumors. [113][114][115][116][117] Colacino et al [118] fabricated an active targeting CNCs coupled to folic acid (FA) (CNC-FA). They discovered through computer simulations and cellular experiments the potential to increase the ablation of the FA receptor-positive cancer cells without altering the IRE parameters and without causing further damage to healthy tissue (Figure 3).…”

Section: Cncsmentioning

confidence: 99%

New progress in tumor treatment based on nanoparticles combined with irreversible electroporation

et al. 2022

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Nanoknife is a new tumor ablation technology. It forms nano permanent perforation on tumor cells by releasing high-voltage pulses, destroying the intracellular balance and making cells apoptosis rapidly. So nano knife is also known as irreversible electroporation (IRE). IRE ablation technology and nanoparticles (NPs) have unique advantages in tumor treatment. Relevant studies have confirmed that NPs can enhance the effect of IRE ablation, expand the ablation boundary and reduce the threshold intensity of tumor cell perforation. Moreover, IRE combined with the drug-loaded NPs can synergize tumor immunotherapy. Thus, the combination of NPs and IRE has broad research prospects. This paper reviews the mechanism of tumor treatment with NPs combined with IRE and discusses the future challenges and opportunities of combining these two technologies.

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Cellulose nanocrystals reinforced highly stretchable thermal-sensitive hydrogel with ultra-high drug loading

Cited by 43 publications

References 40 publications

Poly(N-isopropylacrylamide)-Based Hydrogels for Biomedical Applications: A Review of the State-of-the-Art

Poly(N-isopropylacrylamide)-Based Hydrogels for Biomedical Applications: A Review of the State-of-the-Art

Aggressive strategies for regenerating intervertebral discs: stimulus-responsive composite hydrogels from single to multiscale delivery systems

New progress in tumor treatment based on nanoparticles combined with irreversible electroporation

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