Cellulose nanocrystals as carriers in medicine and their toxicities: A review

Seabra, Amedea B.; Bernardes, Juliana S.; Fávaro, Wagner José; Paula, Amauri J.; Durán, Nélson

doi:10.1016/j.carbpol.2017.12.014

Cited by 197 publications

(121 citation statements)

References 60 publications

Supporting

Mentioning

121

Contrasting

Order By: Relevance

“…Carbohydrate scaffolds such as chitosan, cellulose, agar‐agar and alginates, and derivatives thereof, are industrially employed immobilization matrices for enzymes and peptides anchored at high surface densities (Amalraj, Gopi, Thomas, & Haponiuk, ; Bilal & Iqbal, ; Seabra, Bernardes, Fávaro, Paula, & Durán, ; Zdarta, Meyer, Jesionowski, & Pinelo, ). Among those, especially cellulose nanocrystal formulations are being tested for multifunctional layouts, for instance in biomedical and nutraceutical products (Amalraj et al, ; Seabra et al, ; Sharma, Thakur, Bhattacharya, Mandal, & Goswami, ). For installing spatially and stoichiometrically well‐defined biomolecule ensembles (“modules” in Figure ) on predictably shaped nanocarriers, however, protein and nucleic acid biopolymers offer important additional degrees of freedom.…”

Section: Introductionmentioning

confidence: 99%

From stars to stripes: RNA‐directed shaping of plant viral protein templates—structural synthetic virology for smart biohybrid nanostructures

Wege

Koch

2019

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

The self‐assembly of viral building blocks bears exciting prospects for fabricating new types of bionanoparticles with multivalent protein shells. These enable a spatially controlled immobilization of functionalities at highest surface densities—an increasing demand worldwide for applications from vaccination to tissue engineering, biocatalysis, and sensing. Certain plant viruses hold particular promise because they are sustainably available, biodegradable, nonpathogenic for mammals, and amenable to in vitro self‐organization of virus‐like particles. This offers great opportunities for their redesign into novel “green” carrier systems by spatial and structural synthetic biology approaches, as worked out here for the robust nanotubular tobacco mosaic virus (TMV) as prime example. Natural TMV of 300 x 18 nm is built from more than 2,100 identical coat proteins (CPs) helically arranged around a 6,395 nucleotides ssRNA. In vitro, TMV‐like particles (TLPs) may self‐assemble also from modified CPs and RNAs if the latter contain an Origin of Assembly structure, which initiates a bidirectional encapsidation. By way of tailored RNA, the process can be reprogrammed to yield uncommon shapes such as branched nanoobjects. The nonsymmetric mechanism also proceeds on 3'‐terminally immobilized RNA and can integrate distinct CP types in blends or serially. Other emerging plant virus‐deduced systems include the usually isometric cowpea chlorotic mottle virus (CCMV) with further strikingly altered structures up to “cherrybombs” with protruding nucleic acids. Cartoon strips and pictorial descriptions of major RNA‐based strategies induct the reader into a rare field of nanoconstruction that can give rise to utile soft‐matter architectures for complex tasks. This article is categorized under: Biology‐Inspired Nanomaterials > Protein and Virus‐Based Structures Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Biology‐Inspired Nanomaterials > Nucleic Acid‐Based Structures

show abstract

Section: Introductionmentioning

confidence: 99%

From stars to stripes: RNA‐directed shaping of plant viral protein templates—structural synthetic virology for smart biohybrid nanostructures

Wege

Koch

2019

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

show abstract

“…In contrast, some of its derivatives have been employed in food industries, such as cellulose acetate (CA) (Dairi, Ferfera‐Harrar, Ramos, & Garrigós, ), methylcellulose (Sun et al., ), ethylcellulose (Munk, Utoft, Larsen, Needham, & Risbo, ), hydroxyethyl cellulose (HEC) (Gong, Hou, Yang, & Guo, ), sodium carboxymethylcellulose (NaCMC) (Wang et al., ), and hydroxypropylcellulose (Yang & Li, ). According to the manufacturing process, the physicochemical properties of cellulose nanostructures can be classified into three groups: cellulose nanocrystals, cellulose nanofibers, and bacterial cellulose (also called microbial cellulose) (Azeredo, Rosa, & Mattoso, ; Seabra, Bernardes, Fávaro, Paula, & Durán, ). These nanostructures can be self‐assembled spontaneously into supramolecular structures due to the hydrophilic and hydrophobic groups in their structures (Yang & Li, ).…”

Section: Scps In Foodmentioning

confidence: 99%

Self‐Assembled Carbohydrate Polymers for Food Applications: A Review

Valencia

Zare‬

Makvandi

et al. 2019

Comp Rev Food Sci Food Safe

103

View full text Add to dashboard Cite

The self‐assembled natural and synthetic polymers are booming. However, natural polymers obtained from native or modified carbohydrate polymers (CPs), such as celluloses, chitosan, glucans, gums, pectins, and starches, have had special attention as raw material in the manufacture of self‐assembled polymer composite materials having several forms: films, hydrogels, micelles, and particles. The easy manipulation of the architecture of the CPs, as well as their high availability in nature, low cost, and being sustainable and green polymers have been the main positive points in the use of them for different applications. CPs have been used as building blocks for composite structures, and their easy orientation and ordering has given rise to self‐assembled CPs (SCPs). These macromolecules have been little studied for food applications. Nonetheless, their research has grown mainly in the last 5 years as encapsulated food additive wall materials, food coatings, and edible films. The multifaceted properties (systems sensitive to pH, temperature, ionic strength, types of ions, mechanical force, and enzymes) of these devices are leading to the development of advanced food materials. This review article focused on the analysis of SCPs for food applications in order to encourage other research groups for their preparation and implementation.

show abstract

“…Like other nanomaterials, NC shows a high surface to volume ratio and improved solubility compared to natural cellulose. Here, we will focus on materials obtained by self‐assembly of substituted cellulose, since NC has been extensively reviewed (Amalraj, Gopi, Thomas, & Haponiuk, ; Jorfi & Foster, ; Picheth et al, ; Seabra, Bernardes, Fávaro, Paula, & Durán, ).…”

Section: Polysaccharidesmentioning

confidence: 99%

Carbohydrate‐based nanomaterials for biomedical applications

Gim

Zhu

Seeberger

et al. 2019

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

Carbohydrates are abundant biomolecules, with a strong tendency to form supramolecular networks. A host of carbohydrate-based nanomaterials have been exploited for biomedical applications. These structures are based on simple monoor disaccharides, as well as on complex, polymeric systems. Chemical modifications serve to tune the shapes and properties of these materials. In particular, carbohydrate-based nanoparticles and nanogels were used for drug delivery, imaging, and tissue engineering applications. Due to the reversible nature of the assembly, often based on a combination of hydrogen bonding and hydrophobic interactions, carbohydrate-based materials are valuable substrates for the creations of responsive systems. Herein, we review the current research on carbohydratebased nanomaterials, with a particular focus on carbohydrate assembly. We will discuss how these systems are formed and how their properties are tuned. Particular emphasis will be placed on the use of carbohydrates for biomedical applications.

show abstract

Cellulose nanocrystals as carriers in medicine and their toxicities: A review

Cited by 197 publications

References 60 publications

From stars to stripes: RNA‐directed shaping of plant viral protein templates—structural synthetic virology for smart biohybrid nanostructures

From stars to stripes: RNA‐directed shaping of plant viral protein templates—structural synthetic virology for smart biohybrid nanostructures

Self‐Assembled Carbohydrate Polymers for Food Applications: A Review

Carbohydrate‐based nanomaterials for biomedical applications

Contact Info

Product

Resources

About