Cellulose I Nanolayers Designed by Self‐Assembly of its Thiosemicarbazone on a Gold Substrate

Yokota, Shingo; Kitaoka, Takuya; Sugiyama, Junji; Wariishi, Hiroyuki

doi:10.1002/adma.200602761

Cited by 38 publications

(25 citation statements)

References 25 publications

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“…Monosaccharides Glucose (α-D-Glc) -to study the interaction with lectins [17,55] Mannose (α-D-Man) -to specifically detect E. coli bacteria [27,56]-to load anti-HIV prodrug candidates on gold nanoparticles using "thiol-forthiol" ligand place exchange reactions [57]-to study the interactions with lectin Con A to understand more complex carbohydrate-proteins [58,59] (cont. )…”

Section: Sacc Terminal Carbohydrates Applicationsmentioning

confidence: 99%

Self-Assembled Monolayers of Carbohydrate Derivatives on Gold Surfaces

Bhattarai¹,

Neupane²,

Mikhaylov³

et al. 2017

Carbohydrate

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Self-assembled monolayers (SAMs) presenting carbohydrates (glycans) have been widely prepared on gold surfaces to mimic the carbohydrate surfaces that are involved in molecular recognition phenomena in living cells. The binding affinity of carbohydrate immbolized on SAM surfaces to various carbohydrate-binding proteins (such as lectins) can be studied by optical, electrochemical, piezoelectrical and thermal sensing techniques. The lectins present on the surface of pathogens (e.g., bacteria or viruses) can be used as targets for capturing onto carbohydrates immobilized on SAM surfaces. The immobilized carbohydrates can also be used for detecting different types of disease biomarkers present in bodily fluids. Synergistic properties of carbohydrate SAMs and gold nanoparticles can be used for vaccine preparation and drug delivery. By studying different types of glycans, their properties, and the behavior toward recognition of specific pathogens and biomarkers, we can develop not only new therapeutics but also enhance the diagnostic strategies of various diseases. In this chapter, we discuss carbohydrate-terminated SAMs and their common preparation strategies. Next, we focus on roles of different components of SAMs, characterization techniques, and applications.

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Section: Sacc Terminal Carbohydrates Applicationsmentioning

confidence: 99%

Self-Assembled Monolayers of Carbohydrate Derivatives on Gold Surfaces

Bhattarai¹,

Neupane²,

Mikhaylov³

et al. 2017

Carbohydrate

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“…Bacterial cellulose (BC) produced by Acetobacter xylinum is a form of the natural polymer cellulose, [14][15][16][17] whose network is composed of nanofi bers with a dia meter of about 30 nm. [ 18,19 ] BC nanowhiskers have excellent properties including high biocompatibility and a high crystallinity [ 20,21 ] that increases the modulus of whiskers to about 150 GPa.…”

Section: Polymer Graftingmentioning

confidence: 99%

Stimuli‐Responsive Nanocomposite: Potential Injectable Embolization Agent

Chen

Huang

Sun

et al. 2013

Macromol. Rapid Commun.

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Liver cancer remains a significant medical problem and one promising therapeutic approach is to embolize the tumor. One emerging embolization strategy is to use thermoresponsive materials that can be injected but gel at the tumor site. It is now reported on thermoresponsive nanocomposites generated by grafting poly(N-isopropylacrylamide) chains on bacterial cellulose nanowhiskers. Chemical and physical evidences are provided for grafting and demonstrated a sol-gel transition when the temperature is increased above 34.3 °C. Cytotoxicity test in human umbilical vein endothelial cells indicates the excellent biocompatibility of these nanocomposites for use as embolic materials. These results suggest that the nanocomposites offer appropriate properties for embolization of hepatocellular carcinoma.

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“…A flat cellulose nanolayer was prepared on a gold-covered SPR sensor chip (Moritex Corp.) by the terminus immobilization of Cel-TSC in an NMMO solvent [14]. The cellulose-modified SPR chip was thoroughly washed with 80% NMMO/H2O solution at 105°C for 30 min, then with water.…”

Section: Spr Analysismentioning

confidence: 99%

“…SPR analysis was carried out using a model cellulose substrate prepared on a gold-coated SPR sensor chip. This cellulose nanolayer comprised pure cellulose molecules [9,14] and a crystal structure similar to native cellulose (cellulose I) [14], whereas a pulp fiber surface possesses some carboxyl groups [8]. Figure 3 shows the SPR sensorgrams measured in a deionized water system.…”

Section: Affinity Of Cb-a-pam For Cellulosementioning

confidence: 99%