Cellulose-g-poly(2-(dimethylamino)ethylmethacrylate) Hydrogels: Synthesis, Characterization, Antibacterial Testing and Polymer Electrolyte Application

Blažic, Roko; Grgić, Dajana Kučić; Roković, Marijana Kraljić; Vidović, Elvira

doi:10.3390/gels8100636

Cited by 11 publications

(6 citation statements)

References 79 publications

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“…PDMAEMA-PEGDA hydrogels reached 100% conversion (Table , Figure S4) and exhibited swelling properties comparable to the other systems. In contrast to all other hydrogels, which retained a pink color owing to the presence of EY trapped within the 3D network, PDMAEMA-PEGDA hydrogels appeared yellow in color (Figure S6d), which is typically observed for PDMAEMA polymers. − …”

Section: Resultsmentioning

confidence: 93%

Self-Healing Hydrogel Scaffolds through PET-RAFT Polymerization in Cellular Environment

Rigby,

Alipio,

Chiaradia

et al. 2023

Biomacromolecules

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Photo electron/energy transfer-reversible addition–fragmentation chain transfer (PET-RAFT) has emerged as a powerful reversible-deactivation radical polymerization technique, enabling oxygen-tolerant polymerizations with exquisite spatiotemporal control through irradiation with visible light. In contrast to traditional free radical photo-polymerization, which often requires the use of DNA-damaging UV irradiation, PET-RAFT offers a more cytocompatible alternative for the preparation of polymeric materials in cell culture environments. Herein, we report the use of PET-RAFT for the fabrication of self-healing hydrogels using commercially available monomers, reaching high monomer conversions and cell encapsulation efficiencies. Our hydrogels showed the expected rheological and mechanical properties for the systems considered, together with excellent cytocompatibility and spatiotemporal control over the polymerization process. Moreover, hydrogels prepared through this method could be cut and healed again by simply adding further monomer and irradiating the system with visible light, even in the presence of mammalian cells. This study demonstrates for the first time the potential of PET-RAFT polymerization as a viable methodology for the synthesis of self-healing hydrogel scaffolds for cell encapsulation.

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Section: Resultsmentioning

confidence: 93%

Self-Healing Hydrogel Scaffolds through PET-RAFT Polymerization in Cellular Environment

Rigby,

Alipio,

Chiaradia

et al. 2023

Biomacromolecules

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“…The intense absorption band of ePTFE located at 1150–1210 cm –1 is ascribed to the –CF 2 asymmetric and symmetric bands, with a shoulder peak around 1240 cm –1 attributed to the C–C band. , These are the dominant peaks in both the virgin and modified ePTFE films. On the other hand, the DMAEMA monomer exhibits characteristic IR peaks, namely, those of C–N around 11450–1190 cm –1 , − CH 2 bending at 1454 cm –1 , ,, CC at 1636 cm –1 , CO from the ester group observed at 1710–1740 cm –1 , ,− ,, the C–H of the ternary amine –N(CH 3 ) 2 at approximately 2771 and 2822 cm –1 , − , and finally, the asymmetric vibration of CH 3 at about 2951–2972 cm –1 . Owing to the shared chemical composition of DMAEMA and TMAEMA, the majority of absorption peaks, such as C–N and CO, are also present in the FT-IR spectra of the TMAEMA monomer.…”

Section: Resultsmentioning

confidence: 99%

Leveraging the Dielectric Barrier Discharge Plasma Process to Create Regenerative Biocidal ePTFE Membranes

Maggay,

Liao,

Venault

et al. 2023

ACS Appl. Mater. Interfaces

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The utilization of dielectric barrier discharge (DBD) plasma treatment for modifying substrate surfaces constitutes an easy and simple approach with a potential for diverse applications. This technique was used to modify the surface of a commercial porous expanded poly(tetrafluoroethylene) (ePTFE) film with either dimethylaminoethyl methacrylate (DMAEMA) or (trimethylamino)ethyl methacrylate chloride (TMAEMA) monomers, aiming to obtain antibacterial ePTFE. Physicochemical analyses of the membranes revealed that DBD successfully enhanced the surface energy and surface charge of the membranes while maintaining high porosity (>75%) and large pore size (>1.0 μm). Evaluation of the bacteria killing–releasing (K–R) function revealed that both DMAEMA and TMAEMA endowed ePTFE with the ability to kill Escherichia coli bacteria. However, only TMAEMA-grafted ePTFE allowed for the release of dead bacteria from the surface upon washing with sodium hexametaphosphate (SHMP) saline solution, owing to its cationic charge derived from the quaternary amine. Washing with SHMP disturbed the electrostatic force between the polymer brushes and dead bacteria, which caused the release of the dead bacteria. Lastly, dead-end bacteria filtration showed that the TMAEMA-grafted ePTFE was able to kill 99.78% of the bacteria, while approximately 61.55% of bacteria were killed upon contact. The present findings support the feasibility of using DBD plasma treatment for designing surfaces that target bacteria and aid in the containment of disease-causing pathogens.

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“…Furthermore, the polymer network stabilizes particles, thus avoiding the agglomeration of formed particles [72]. In our previous work, it was found that cel-DMAEMA hydrogels enable a reduction in Ag + ions, thus forming Ag particles, which contributed to the antibacterial properties of hydrogels [73]. Here, the influence of PDMAEMA content in hydrogels on the distribution and content of formed Ag particles was investigated in more detail.…”

Section: Hydrogels With Silver Particlesmentioning

confidence: 95%

“…In our previous work [73], the dissolution of cellulose was described. Briefly, cellulose was activated in DMAc at 120 • C for 2 h. The temperature was adjusted to 100 • C and then LiCl (6.6 wt% in DMAc/LiCl solution) was added.…”

Section: Polymerization Reactionmentioning

confidence: 99%

Swelling and Viscoelastic Properties of Cellulose-Based Hydrogels Prepared by Free Radical Polymerization of Dimethylaminoethyl Methacrylate in Cellulose Solution

Blažic

Marušić

Vidović

2023

Gels

Self Cite

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The grafting of a stimuli-responsive polymer (poly(dimethylaminoethyl methacrylate)) onto cellulose was achieved by performing free radical polymerization of a vinyl/divinyl monomer in cellulose solution. The grafting and crosslinking efficiency in the material have been increased by subsequent irradiation of the samples with ionizing radiation (doses of 10, 30, or 100 kGy). The relative amount of poly(dimethylaminoethyl methacrylate) in the prepared hydrogels was determined by infrared spectroscopy. The swelling behavior of the hydrogels was studied thoroughly, including microgelation extent, equilibrium swelling, and reswelling degree, as well as the dependence on the gelation procedure. The dynamic viscoelastic behavior of prepared hydrogels was also studied. The tan δ values indicate a solid-like behavior while the obtained hydrogels have a complex modulus in the range of 14–39 kPa, which is suitable for hydrogels used in biomedical applications. In addition, the incorporation of Ag particles and the adsorption of Fe3+ ions were tested to evaluate the additional functionalities of the prepared hydrogels. It was found that the introduction of PDMAEMA to the hydrogels enhanced their ability to synthesize Ag particles and absorb Fe3+ ions, providing a platform for the potential preparation of hydrogels for the treatment of wounds.

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Cellulose-g-poly(2-(dimethylamino)ethylmethacrylate) Hydrogels: Synthesis, Characterization, Antibacterial Testing and Polymer Electrolyte Application

Cited by 11 publications

References 79 publications

Self-Healing Hydrogel Scaffolds through PET-RAFT Polymerization in Cellular Environment

Self-Healing Hydrogel Scaffolds through PET-RAFT Polymerization in Cellular Environment

Leveraging the Dielectric Barrier Discharge Plasma Process to Create Regenerative Biocidal ePTFE Membranes

Swelling and Viscoelastic Properties of Cellulose-Based Hydrogels Prepared by Free Radical Polymerization of Dimethylaminoethyl Methacrylate in Cellulose Solution

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