Cellulose alters the expression of nuclear factor kappa B-related genes and Toll-like receptor-related genes in human peripheral blood mononuclear cells

Vogt, Leonie M.; Boekschoten, Mark V.; Groot, Philip J. de; Faas, Marijke M.; Vos, Paul de

doi:10.1016/j.jff.2015.08.011

Cited by 5 publications

(4 citation statements)

References 79 publications

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“…Moreover, an increased cellular immune response was observed with the addition of CEL into the diet, which coincides with previous reports of CEL immunomodulatory activity. This may result from the changes in gene expression of several molecules upon stimulation with CEL; molecules, such as nuclear factor kappa B (NF-κB), are activated via signaling pathways when CEL bind Toll-like and c-type lectin receptors, besides several genes within these pathways, are downregulated in their expression, which modulates cytokine profiles and immune status [ 83 , 84 ]. Additionally, as discussed above, CUR has been shown to be an effective natural chemoprotector against the toxic effects of AFB1 through three primary mechanisms, its antioxidant effects, immunomodulatory actions, and inhibitory activities against cytochrome P450 isoenzymes, without forgetting its significant hepatoprotective properties [ 40 , 85 ], which, due to the increase in its bioavailability, and thus, its efficiency and functionality were potentialized.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Cellulosic Polymers and Curcumin to Reduce Aflatoxin B1 Toxic Effects on Performance, Biochemical, and Immunological Parameters of Broiler Chickens

Solís-Cruz

Hernández-Patlán

Petrone

et al. 2019

Toxins

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To evaluate the effect of cellulosic polymers (CEL) and curcumin (CUR) on aflatoxin B1 (AFB1) toxic effects on performance, and the biochemical and immunological parameters in broiler chickens, 150 one-day-old male broiler chicks were randomly allocated into five groups with three replicates of 10 chickens per pen: Negative Control (feed); AFB1 (feed + 2 ppm AFB1); CUR (feed + 2 ppm AFB1 + Curcumin 0.2%); CEL (feed + 2 ppm AFB1 + 0.3% Cellulosic polymers); and, CEL + CUR (feed + 2 ppm AFB1 + 0.3% Cellulose polymers + 0.2% Curcumin). Every week, body weight, body weight gain, feed intake, and feed conversion ratio were calculated. On day 21, liver, spleen, bursa of Fabricius, and intestine from five broilers per replicate per group were removed to obtain relative organ weight. Histopathological changes in liver, several biochemical biomarkers, antibody titers, and muscle and skin pigmentation were also recorded. Dietary addition of 0.3% CEL and 0.2% CUR separately significantly diminished some of the toxic effects resulting from AFB1 on performance parameters, relative organs weight, histopathology, immune response, and serum biochemical variables (P < 0.05); however, the combination of CUR and CEL showed a better-integrated approach for the management of poultry health problems that are related with the consumption of AFB1, since they have different mechanisms of action with different positive effects on the responses of broiler chickens.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Cellulosic Polymers and Curcumin to Reduce Aflatoxin B1 Toxic Effects on Performance, Biochemical, and Immunological Parameters of Broiler Chickens

Solís-Cruz

Hernández-Patlán

Petrone

et al. 2019

Toxins

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“…A recent study reported an immunomodulatory potential of cellulose and demonstrated cellulose-mediated activation of toll-like receptor (TLR) dependent pathways, primarily involving TLR2 and TLR4 receptors, in THP-1 cells . Of all the known TLRs, TLR4 acts as signal-transducing receptor for LPS, a Gram-negative bacterial cell wall component. − Upon treatment, LPS is shown to trigger a rapid inflammatory response through the release of several pro-inflammatory cytokines/chemokines including IL-1β, IL-6, IL-8, and TNFα .…”

Section: Discussionmentioning

confidence: 99%

In Vitro Toxicity Evaluation of Lignin-(Un)coated Cellulose Based Nanomaterials on Human A549 and THP-1 Cells

et al. 2016

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A significant amount of research toward commercial development of cellulose based nanomaterials (CNM) is now in progress with some potential applications. Using human A549 and THP-1 cells, we evaluated the biological responses of various CNMs, made out of similar material but with functional and morphological variations. While A549 cells displayed minimal or no cytotoxic responses following exposure to CNMs, THP-1 cells were more susceptible to cytotoxicity, cellular damage and inflammatory responses. Further analysis of these biological responses evaluated using hierarchical clustering approaches was effective in discriminating (dis)-similarities of various CNMs studied and identified potential inflammatory factors contributing to cytotoxicity. No correlation between cytotoxicity and surface properties of CNMs was found. This study clearly highlights that, in addition to the source and characteristics of CNMs, cell type-specific differences in the recognition/uptake of CNMs along with their inherent capability to respond to external stimuli are crucial for assessing the toxicity of CNMs.

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“…Cellulose, methylcellulose, and agarose are all also used commonly in the biomedical industry. Cellulose does induce toll-like receptor (TLR)2-mediated NF-κB activation, promoting immunomodulatory responses, 37 however, these materials are mainly considered inert and suitable for in vitro assays. The limitation of using these materials is that mammalian cells lack receptors to bind to these plant-based polysaccharides, and do not produce catabolic enzymes to degrade them.…”

Section: Functions and Bioactivities Of Natural Polymersmentioning

confidence: 99%

Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties

Joyce

Fabra

Bozkurt

et al. 2021

Sig Transduct Target Ther

149

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Biomaterials have had an increasingly important role in recent decades, in biomedical device design and the development of tissue engineering solutions for cell delivery, drug delivery, device integration, tissue replacement, and more. There is an increasing trend in tissue engineering to use natural substrates, such as macromolecules native to plants and animals to improve the biocompatibility and biodegradability of delivered materials. At the same time, these materials have favourable mechanical properties and often considered to be biologically inert. More importantly, these macromolecules possess innate functions and properties due to their unique chemical composition and structure, which increase their bioactivity and therapeutic potential in a wide range of applications. While much focus has been on integrating these materials into these devices via a spectrum of cross-linking mechanisms, little attention is drawn to residual bioactivity that is often hampered during isolation, purification, and production processes. Herein, we discuss methods of initial material characterisation to determine innate bioactivity, means of material processing including cross-linking, decellularisation, and purification techniques and finally, a biological assessment of retained bioactivity of a final product. This review aims to address considerations for biomaterials design from natural polymers, through the optimisation and preservation of bioactive components that maximise the inherent bioactive potency of the substrate to promote tissue regeneration.

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Cellulose alters the expression of nuclear factor kappa B-related genes and Toll-like receptor-related genes in human peripheral blood mononuclear cells

Cited by 5 publications

References 79 publications

Evaluation of Cellulosic Polymers and Curcumin to Reduce Aflatoxin B1 Toxic Effects on Performance, Biochemical, and Immunological Parameters of Broiler Chickens

Evaluation of Cellulosic Polymers and Curcumin to Reduce Aflatoxin B1 Toxic Effects on Performance, Biochemical, and Immunological Parameters of Broiler Chickens

In Vitro Toxicity Evaluation of Lignin-(Un)coated Cellulose Based Nanomaterials on Human A549 and THP-1 Cells

Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties

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