Cellulose acetate nanofibers loaded with crude annatto extract: Preparation, characterization, and in vivo evaluation for potential wound healing applications

Santos, Ana Elisa Antunes dos; Santos, Francisco Vieira dos; Freitas, Kátia Michelle; Pimenta, Lúcia Pinheiro Santos; Andrade, Luciana de Oliveira; Marinho, Tamires Amorim; Avelar, Gleide Fernandes de; Silva, Aline Bruna da; Ferreira, Roberta Viana

doi:10.1016/j.msec.2020.111322

Cited by 60 publications

(30 citation statements)

References 64 publications

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“…Nanofiber diameter is a vital factor for regulating the release of drugs. The mean CA diameters in this study are smaller than those reported in several previous works 16,23,29,30 but higher than in another 31 . The average PCLNF diameters recorded in the current study are also lower than in the previous studies 32,33 .…”

Section: Resultscontrasting

confidence: 81%

“…The peak at 1372.9 cm −1 is due to the bending vibration of CH 3. 31 The ATR peaks obtained in this study are equivalent to those reported in the CA nanofiber literature 16,36,42 …”

Section: Resultssupporting

confidence: 76%

“…The drug‐loaded electrospun nanofibers were made from cellulose acetate (CA) polymers and used to compact the drug within the implant's core. CA is a biocompatible, partially biodegradable, nonirritating, and nontoxic polymer 16 . This polymer has been commonly used in drug delivery systems due to its mechanical properties, high affinity to other materials, and renewable properties 11 …”

Section: Introductionmentioning

confidence: 99%

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Development of prolonged drug delivery system using electrospun cellulose acetate/polycaprolactone nanofibers: Future subcutaneous implantation

Wsoo

Razak

Shahir

et al. 2021

Polymers for Advanced Techs

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Implantable drug delivery systems (IDDSs) play a vital role in treating chronic diseases by reducing dosing frequency and enhancing drug efficacy due to targeted delivery. In the present study, an IDDS was developed from electrospun cellulose acetate (CA) and polycaprolactone (PCL) nanofiber membranes. The implant core consists of a drug‐loaded CA nanofiber (CA + Vit.D3) enclosed in a rate limiting of the PCL membrane (CA + Vit.D3/PCL). The CA and PCL nanofibrous membranes were characterized using a scanning electron microscope (SEM), Fourier transform infrared spectroscopy, X‐ray diffraction, and UV–Vis spectroscopy. This research also investigated in‐vitro cytotoxicity and whether the PCL membrane prolonged drug delivery or led to enhanced mechanical properties. A smooth, beadless surface morphology was observed with fiber diameters of 325 ± 101 nm and 333 ± 79 nm for CA and PCL, respectively. In‐vitro drug release and tensile testing showed that surrounding the core's implants with a PCL membrane improved mechanical properties and kinetic drug release. The modulus and tensile strength of CA + Vit.D3/PCL were 161 ± 14 and 13.07 ± 2.5 MPa, respectively—these values were significantly higher than those obtained for CA + Vit.D3 (132 ± 52 MPa and 8.16 ± 2.36 MPa, respectively). The drug release pattern exhibited by CA + Vit.D3 was burst release, which fits the first‐order kinetic model. In contrast, CA + Vit.D3/PCL exhibited slow drug release, which fits the zero‐order kinetic model. In conclusion, based on the outcomes and facility of the technologies outlined in this article, electrospun CA and PCL nanofibers are suitable for developing long‐term IDDSs.

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Section: Resultscontrasting

confidence: 81%

“…The peak at 1372.9 cm −1 is due to the bending vibration of CH 3. 31 The ATR peaks obtained in this study are equivalent to those reported in the CA nanofiber literature 16,36,42 …”

Section: Resultssupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Development of prolonged drug delivery system using electrospun cellulose acetate/polycaprolactone nanofibers: Future subcutaneous implantation

Wsoo

Razak

Shahir

et al. 2021

Polymers for Advanced Techs

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show abstract

“…According to the literature, the density of cellulose is 1.50 g cm −3 ( Pereira et al, 2020 ). The densities of the additives used in the production of the aerogel composites are (ρ additive ): algae—1.02 g cm −3 ( Zhu, Lu & Dai, 2018 ), straw—1.1 g cm −3 ( Lam et al, 2007 ), wool—1.3 g cm −3 ( Kozyreff et al, 2003 ), and cellulose acetate—1.3 g cm −3 ( dos Santos et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

Cellulose aerogel composites as oil sorbents and their regeneration

Paulauskienė¹,

Uebe²,

Ziogas³

2021

PeerJ

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Background With every oil tanker comes the risk of an accident and oil spill. Sorbents are the most suitable means to remove oil spills. Aerogels as sorbents have high porosity and can be made from cellulose from paper waste. The literature does not distinguish between paper and cardboard as sources of cellulose aerogels and little is known about composites of cellulose aerogels consisting of cellulose fibres and chemically untreated, unprocessed fibres or particles of straw, wool, macroalgae or cellulose acetate from cigarette butts. In this study, the sorption properties for marine diesel oil and biodiesel of such aerogels and their regenerative capacity with bioethanol were investigated. Methods Cellulose aerogels were prepared from office paper and cardboard waste without and with chemically untreated algae, straw, wool and cellulose acetate as a composite by freeze drying. All samples were hydrophobised with methylsilane. The density to calculate the porosity and the contact angle were determined. Then the sorption capacity was determined over five cycles of sorption of oil and regeneration with bioethanol. Results The average contact angle of all samples was 125°, indicating hydrophobicity. Paper-based aerogels were found to consistently have higher sorption capacities for biodiesel, marine diesel oil and bioethanol than cardboard-based aerogels. In particular, the wool/cellulose aerogel composite was found to have better sorption capacity for biodiesel, marine diesel oil and bioethanol than all other samples. The cellulose acetate/cellulose aerogel composite showed significantly higher sorption capacities than the paper and cardboard control samples (highest value is 32.25 g g−1) only when first used as a sorbent for biodiesel, but with a rapid decrease in the following cycles.

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“…In a recent study, Santos et al [ 81 ] had synthesized electrospun cellulose acetate fibers, modified in volume with an annatto extract. The prepared material was evaluated as a wound dressing, able to induce the antibacterial and anti-inflammatory reactions.…”

Section: Examples Of the Electrospinnable Biopolymersmentioning

confidence: 99%

Advances in Fabricating the Electrospun Biopolymer-Based Biomaterials

Wilk

Benko

2021

JFB

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Biopolymers formed into a fibrous morphology through electrospinning are of increasing interest in the field of biomedicine due to their intrinsic biocompatibility and biodegradability and their ability to be biomimetic to various fibrous structures present in animal tissues. However, their mechanical properties are often unsatisfactory and their processing may be troublesome. Thus, extensive research interest is focused on improving these qualities. This review article presents the selection of the recent advances in techniques aimed to improve the electrospinnability of various biopolymers (polysaccharides, polynucleotides, peptides, and phospholipids). The electrospinning of single materials, and the variety of co-polymers, with and without additives, is covered. Additionally, various crosslinking strategies are presented. Examples of cytocompatibility, biocompatibility, and antimicrobial properties are analyzed. Special attention is given to whey protein isolate as an example of a novel, promising, green material with good potential in the field of biomedicine. This review ends with a brief summary and outlook for the biomedical applicability of electrospinnable biopolymers.

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Cellulose acetate nanofibers loaded with crude annatto extract: Preparation, characterization, and in vivo evaluation for potential wound healing applications

Cited by 60 publications

References 64 publications

Development of prolonged drug delivery system using electrospun cellulose acetate/polycaprolactone nanofibers: Future subcutaneous implantation

Development of prolonged drug delivery system using electrospun cellulose acetate/polycaprolactone nanofibers: Future subcutaneous implantation

Cellulose aerogel composites as oil sorbents and their regeneration

Advances in Fabricating the Electrospun Biopolymer-Based Biomaterials

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