Cellulitis

Raff, Adam B.; Kroshinsky, Daniela

doi:10.1001/jama.2016.8825

Cited by 314 publications

(169 citation statements)

References 108 publications

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“…Further, animals are maintained in a controlled sterile environment and mice do not develop secondary chronic lymphedema. Another limitation of this study is that it does not address a role, if any, for Streptococci and methicillin susceptible S. aureus (MSSA) on lymphatic impairment, as Group A Streptococci and MSSA are also common pathogens associated with SSTIs (4). It is likely that MSSA can blunt CLV function through agr -mediated toxin production, albeit MSSA toxin production is lower than that of MRSA (37).…”

Section: Discussionmentioning

confidence: 99%

“…However, complicated infections may additionally require intravenous antibiotics, leading to nearly 500,000 hospital admissions each year in the US (2, 3). The most common pathogens associated with bacterial infections of the skin and underlying tissues are beta-hemolytic Streptococci and Staphylococcus aureus, including strains of methicillin-resistant Staphylococcus aureus (MRSA) (4). The resistance of MRSA to antibiotics, along with an increasing incidence of infections, has become a growing public health concern for individuals in the community and hospital settings (5), and underscores the need for treatments that target both MRSA colonization and its pathogenesis (6).…”

Section: Introductionmentioning

confidence: 99%

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Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction

et al. 2018

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Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of morbidity and mortality worldwide and is a frequent cause of skin and soft tissue infections (SSTIs). Lymphedema—fluid accumulation in tissue caused by impaired lymphatic vessel function—is a strong risk factor for SSTIs. SSTIs also frequently recur in patients and sometimes lead to acquired lymphedema. However, the mechanism of how SSTIs can be both the consequence and cause of lymphatic vessel dysfunction is not known. Intravital imaging in mice revealed both an acute reduction in lymphatic vessel contractility and lymph flow after localized MRSA infection. Moreover, chronic lymphatic impairment is observed long after MRSA is cleared and inflammation is resolved. Associated with decreased collecting lymphatic vessel function was the loss and disorganization of lymphatic muscle cells (LMCs), which are critical for lymphatic contraction. In vitro, incubation of MRSA-conditioned supernatant led to LMC death. Proteomic analysis identified several accessory gene regulator (agr)-controlled MRSA exotoxins that contribute to LMC death. Infection with agr mutant MRSA resulted in sustained lymphatic function compared to animals infected with wild type MRSA. Our findings suggest that agr is a promising target to preserve lymphatic vessel function and promote immunity during SSTIs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction

et al. 2018

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“…Cellulitis is a common infectious disease with poorly demarcated skin inflammation. 1 It is challenging in diagnosis and management. 2 A third of cellulitis patients could be misdiagnosed.…”

Section: Non-invasive Assessment Of Cellulitis From Snapshot Hyperspementioning

confidence: 99%

“…4 However, clinical assessments, rather than image or laboratory measures, are used to evaluate treatment efficacy. 1,5,6 Therefore, it is imperative to establish a rapid and objective method to evaluate cellulitis.…”

Section: Non-invasive Assessment Of Cellulitis From Snapshot Hyperspementioning

confidence: 99%

Non‐invasive assessment of cellulitis from snapshot hyperspectral imaging – A primary study

Chen

Chao

et al. 2018

Skin Research and Technology

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“…polycystic kidney) and repetitive exposures to nosocomial microorganisms can increase the risk of the occurrence of sepsis [40]. The most common source of infection is represented by indwelling catheters followed by lower respiratory tract infections [41], cellulitis and pyocystis [42,43] as well as the breaching of cutaneous barriers. Catheters and prosthetic arteriovenous grafts represent a nidus for infection.…”

Section: Ckd/eskd Patients Admitted In the Icumentioning

confidence: 99%

Management of Chronic Kidney Disease Patients in the Intensive Care Unit: Mixing Acute and Chronic Illness

Rosa

Samoni²,

Villa³

et al. 2017

Blood Purif

3,608

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Patients with chronic kidney disease (CKD) are at high risk for developing critical illness and for admission to intensive care units (ICU). ‘Critically ill CKD patients' frequently develop an acute worsening of renal function (i.e. acute-on-chronic, AoC) that contributes to long-term kidney dysfunction, potentially leading to end-stage kidney disease (ESKD). An integrated multidisciplinary effort is thus necessary to adequately manage the multi-organ damage of those kidney patients and contemporaneously reduce the progression of kidney dysfunction when they are critically ill. The aim of this review is to describe (1) the pathophysiological mechanisms underlying the development of AoC kidney dysfunction and its role in the progression toward ESKD; (2) the most common clinical presentations of critical illness among CKD/ESKD patients; and (3) the continuum of care for CKD/ESKD patients from maintenance hemodialysis/peritoneal dialysis to acute renal replacement therapy performed in ICU and, vice-versa, for AoC patients who develop ESKD.

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Cellulitis

Cited by 314 publications

References 108 publications

Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction

Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction

Non‐invasive assessment of cellulitis from snapshot hyperspectral imaging – A primary study

Management of Chronic Kidney Disease Patients in the Intensive Care Unit: Mixing Acute and Chronic Illness

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