Cellulite: Is there a role for injectables?

Rotunda, Adam M.; Avram, Mathew M.; Avram, Alison Sharpe

doi:10.1080/14764170500430234

Cited by 43 publications

(35 citation statements)

References 86 publications

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“…[47][48][49] Some studies have been revised regarding the role of mesotherapy in gynoid lipodystrophy 50 and others regarding the role of mesotherapy lipolysis. 3,6,51 These revisions offer the conclusion that, theoretically, a subcutaneous injection of specified products can function, but they lack indexed scientific publications on which to base this technique.…”

Section: Literature Reviewmentioning

confidence: 99%

Mesoterapia: uma revisão bibliográfica

Herreros

Moraes²,

Velho³

2011

An. Bras. Dermatol.

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Intradermotherapy is a medical procedure introduced by Pistor in 1958 that consists in the application of intradermal injections of diluted pharmacological substances that are given directly into the region to be treated. There are reports of the use of intradermotherapy to treat painful diseases, skin diseases and unaesthetic conditions. Medical clinics have been recently offering the treatment of intradermotherapy, using the more popular name for this practice -mesotherapy. There is only scant scientific information about this subject published in periodicals indexed on MedLine. Only a few states rigorously pursue this method. Most indexed publications about this subject deal with the complications of this technique. Unaesthetic dermatoses have been a common complaint in dermatologic clinics, and it has become necessary to have scientific evidence to give to patients. Therefore, well-researched scientific studies about this technique are necessary to offer data to medical professionals that will clearly explain to patients both the benefits and the risks of these procedures. A bibliographical review was conducted and we verified the need for new studies with adequate methods to confirm the benefits of intradermotherapy as used in dermatologic treatment. Keywords: Injections, intradermal; Review; Skin; Therapeutics Resumo: A intradermoterapia é um procedimento médico introduzido por Pistor, em 1958, e consiste na aplicação, diretamente na região a ser tratada, de injeções intradérmicas de substâncias farmacológicas muito diluídas. Esse método é capaz de estimular o tecido que recebe os medicamentos tanto pela ação da punctura quanto pela ação dos fármacos, e apregoa-se que sua vantagem é evitar o uso de medicação sistê-mica. Há relatos da utilização da intradermoterapia para tratamento de doenças dolorosas, dermatoses e condições consideradas inestéticas. Atualmente, clínicas médicas oferecem esse tratamento, utilizando, porém, o nome mais popular para essa prática, mesoterapia. Há escassa informação científica sobre o tema publicada em periódicos indexados no MedLine e poucos estudos com metodologia mais rigorosa sobre a eficácia e o mecanismo de ação da via intradérmica. A maioria das publicações indexadas sobre esse tema versa sobre as complicações dessa técnica. As dermatoses inestéticas têm se tornado queixas frequentes nos consultórios dermatológicos, sendo necessário um embasamento científico para lidar com tais pacientes, os quais, muitas vezes, estão em busca das novidades mostradas através da mídia. Assim, há necessidade de estudos cientificamente bem conduzidos sobre essa técnica. Estes estudos deverão oferecer aos médicos elementos para esclarecer os pacientes sobre quais benefícios esperar e quais os riscos de tal abordagem. Desse modo, realizou-se uma revisão bibliográfica sobre o assunto e constatou-se a necessidade de novos estudos com metodologia adequada para a confirmação dos benefícios da intradermoterapia como ferramenta útil no tratamento dermatológico.

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Section: Literature Reviewmentioning

confidence: 99%

Mesoterapia: uma revisão bibliográfica

Herreros

Moraes²,

Velho³

2011

An. Bras. Dermatol.

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“…Prior to these findings, the only clinically confirmed treatment of NASH was weight reduction (Moschen and Tilg, 2008). Fat dissolving local injections have two therapeutic effects; First, the injected reagents are toxic to adipose and other associated cells, causing permanent removal of fat tissue; second, the injections have been associated with a temporary decrease in the fat stores, resulting in smaller fat cells (Rotunda et al, 2005). The results of this study showed that the effects of PTX on adipocyte cells differed according to the PTX concentration.…”

Section: Discussionmentioning

confidence: 99%

“…Mesotherapy, originally introduced in Europe, is a minimally invasive technique that consists of the intra-or subcutaneous injection of variable mixtures of natural plant extracts, homeopathic agents, pharmaceuticals, vitamins, and other bioactive substances (Accessed February 2nd, 2009). The use of mesotherapy in cosmetic medicine, to reduce and contour subcutaneous fat, is gaining popularity (Rotunda et al, 2005;Doerr, 2007), however, the safety and efficacy of this treatment has not been scientifically validated.…”

Section: Introductionmentioning

confidence: 99%

Pentoxifylline Induces Lipolysis and Apoptosis of Human Preadipocytes, Keratinocytes and Fibroblasts In Vitro

Lee¹,

Choi

Shim³

et al. 2010

Biomolecules and Therapeutics

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-Pentoxifylline (PTX) has been used for the local reduction of fat tissue in the clinical setting. However, its safety and efficacy have not been proven. The aim of this study was to evaluate the effects of PTX on cell lines established from fat tissue. Newly cultured human preadipocytes and adipocytes from subcutaneous abdominal fat in addition to purchased human lung fibroblasts and keratinocytes were treated with PTX at different concentrations. Cell viability was determined using the Cell counting kit (CCK)-8 assay and lipolysis was evaluated using an Elisa kit. DNA fragmentation, Western blot analysis, Hoechst and Propidium Iodide (PI) staining and fluorescence activated cell scanning analysis were performed to confirm apoptosis. The viability of adipocytes, preadipocytes, keratinocytes and fibroblasts was markedly decreased at concentrations of PTX above 20 mM. Apoptosis was induced at concentrations of PTX over 40 mM in all cell lines. Lipolysis was increased by 60% at concentrations of PTX of 20 mM compared to the control. In conclusion, the results of this study showed that 20 mM of PTX induced lipolysis. At concentrations over 20 mM, PTX reduced the viability of all cells studied including: adipocytes, preadipocytes, fibroblasts and keratinocytes, in a non-specific manner.

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“…LPL is located on endothelial walls of capillaries and is responsible for serum chylomicron (from dietary lipids) and very low-density lipoprotein breakdown. Lipolysis may also be induced by medication binding to specific adrenergic receptors (α or β) located on adipocyte membranes [15][16][17][18]. A novel medication currently being developed by Lithera, Inc. (San Diego, CA) is termed "LIPO-102" and its use as an injectable fat reducer is called "pharmaceutical lipoplasty."…”

Section: Clarification Of Terms and History Lipolysis Injection Lipomentioning

confidence: 99%