Cellulase as an “active” excipient in prolonged-release HPMC matrices: A novel strategy towards zero-order release kinetics

Palugan, Luca; Filippin, Ilaria; Cirilli, Micol; Moutaharrik, Saliha; Zema, L.; Cerea, Matteo; Maroni, Alessandra; Foppoli, Anastasia; Gazzaniga, A.

doi:10.1016/j.ijpharm.2021.121005

Cited by 4 publications

(2 citation statements)

References 33 publications

(34 reference statements)

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“…Although at different times, all printed tablets showed a sustained and complete drug release within 48 h. In fact, HP-β-CD-containing formulations (3 and 4) achieved 100% NCS release in 24 h. In contrast, formulations 1 and 2 released 65% and 70% of NCS at 24 h, respectively, achieving complete drug release at 48 h. The different release profile of the tablets could be related to the different concentration of HPMC that constitutes them. In fact, the HPMC interacting with the aqueous fluid led to the formation of a gel layer, which acts as a diffusion barrier that counteracted drug release [ 43 ]. Several studies have been found in the literature concerning the behavior of HPMC when it is placed in contact with aqueous fluids [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

“…In fact, the HPMC interacting with the aqueous fluid led to the formation of a gel layer, which acts as a diffusion barrier that counteracted drug release [ 43 ]. Several studies have been found in the literature concerning the behavior of HPMC when it is placed in contact with aqueous fluids [ 43 ]. Palugan et al demonstrated the previously described phenomenon and provided as a potential solution the use of cellulolytic products capable of degrading the HPMC matrix more rapidly.…”

Section: Resultsmentioning

confidence: 99%

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Direct cyclodextrin-based powder extrusion 3D printing for one-step production of the BCS class II model drug niclosamide

Pistone

Racaniello

Arduino

et al. 2022

Drug Deliv. and Transl. Res.

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Niclosamide (NCS) is a drug that has been used as an anthelmintic and anti-parasitic drug for about 40 years. Recently, some studies have highlighted its potential in treating various tumors, allowing a repositioning of this drug. Despite its potential, NCS is a Biopharmaceutical Classification System (BCS) Class II drug and is consequently characterized by low aqueous solubility, poor dissolution rate and reduced bioavailability, which limits its applicability. In this work, we utilize a very novel technique, direct powder extrusion (DPE) 3D printing, which overcomes the limitations of previously used techniques (fused deposition modelling, FDM) to achieve direct extrusion of powder mixtures consisting of NCS, hydroxypropyl methylcellulose (HPMC, Affinisol 15 LV), hydroxypropyl-β-cyclodextrin (HP-β-CD) and polyethylene glycol (PEG) 6000. For the first time, direct printing of powder blends containing HP-β-CD was conducted. For all tablets, in vitro dissolution studies showed sustained drug release over 48 h, but for tablets containing HP-β-CD, the release was faster. Solid-state characterization studies showed that during extrusion, the drug lost its crystal structure and was evenly distributed within the polymer matrix. All printed tablets have exhibited good mechanical and physical features and a stability of the drug content for up to 3 months. This innovative printing technique has demonstrated the possibility to produce personalized pharmaceutical forms directly from powders, avoiding the use of filament used by FDM. Graphical abstract

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%