Cellularity of Lobular Carcinoma and Its Relationship to False Negative Fine Needle Aspiration Results

Cytomorphology of Common Malignant Tumors of the Breast

“…9). Variant patterns of lobular carcinoma, such as alveolar, solid, pleomorphic, or mixed patterns, can yield more cellular specimens composed of larger cells and arranged in clusters and sheets, each of which is more typical of ductal carcinoma [19][20][21][22][23][24][25][26][27]. De las Morenas and coworkers [28] have suggested that chromatin pattern may be a helpful distinguishing feature, because a coarse chromatin pattern has only been observed in ductal carcinoma.…”

Fine Needle Biopsy Cytology of Breast Lesions

“…On close examination in high power, the nuclear shape and chromatin pattern are abnormal, but the difference from nonneoplastic terminal ductal epithelium can be subtle. [71][72][73][74][75] In most cases only a small number of cells can be extracted from these fibrosclerotic tumors by FNA. The microtubular and microglandular groupings of cells of tubular carcinoma resemble those of adenosis/sclerosing adenosis (see Fig.…”

Accuracy of Fine Needle Aspiration Cytology in Diagnosing Various Breast Lesions With Histopathological Correlation

“…It has been documented that the cellularity of an invasive lobular carcinoma in cytology smears correlates with histopathological architectural pattern rather than with the original histopathological cellularity. (11) In the case which was cytologically diagnosed as Phyllodes tumour with epithelial hyperplasia, but turned out to be Malignant phyllodes on HPE, the aspiration was blood mixed grey-white material. Smears showed moderate cellularity comprising of epithelial cells in cohesive sheets, in 3D clusters along with stromal fragments.…”