Cellularity of atherosclerotic lesions

The Role of the Platelet in the Pathogenesis of Atherothrombosis

“…[9] Subsequent lesion development may result in progressive arterial As well as producing mediators of cell adhesion and thrombostenosis, potentially leading to symptoms of stable angina or sis, the platelet contains numerous inflammatory proteins, includintermittent claudication. However, erosion or rupture of an unstaing P-selectin, thrombospondin-1, platelet factor-4, TGF-±, and ble atherosclerotic plaque triggers an acute thrombotic process RANTES (Regulated upon Activation Normally T-cell Expressed leading to the rapid formation of a platelet-rich thrombus that may and Secreted), which are stored within cytosolic β-granules.…”

Monocyte Chemoattractant Protein-1 but Not Tumor Necrosis Factor-α Is Correlated With Monocyte Infiltration in Mouse Lipid Lesions

“…6 -9 Macrophages and T cells constitute Ϸ40% of the total population of cells in the lipid core region of atherosclerotic plaques. 1,10,11 Their recruitment to the lesion may depend on alterations in the adhesive properties of the endothelial surface. [12][13][14] Increased endothelial cell permeability and endothelial cell activation are among the earliest changes associated with developing lesions of atherosclerosis.…”

Contribution of Proliferating Leukocytes to Phenotypic Change in Smooth Muscle Cells during the Development of Coronary Arteriosclerosis in Transplanted Hearts

“…Interestingly, HIS36+ and R73+ cells were also found in the same area, which suggests that the subtype of the PCNA+ cells may be T cells and macrophages. Therefore, macrophages and T cells probably contribute to arteriosclerosis of the coronary arteries in the transplanted heart [24,[27][28][29].…”