Cellular uptake of collagens and implications for immune cell regulation in disease

Jürgensen, Henrik J.; Putten, Sander van; Nørregaard, Kirstine Sandal; Bugge, Thomas H.; Engelholm, Lars H.; Behrendt, Niels; Madsen, Daniel H.

doi:10.1007/s00018-020-03481-3

Cited by 28 publications

(19 citation statements)

References 151 publications

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“…Integrins are surface receptors mediating cell-matrix and cell-cell adhesion, which transmit bidirectional signals between cancer cells and the ECM. Integrins are also key components of migration machinery, which determine the colonization sites of metastatic cells and facilitate the survival of these cells [ 51 , 52 ]. In fact, several pro-survival signals such as PI3K and MAPK pathways should depend on cells that adherent to the ECM via integrins, and the ECM molecules may amplify these signals [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of prognostic biomarkers associated with the occurrence of portal vein tumor thrombus in hepatocellular carcinoma

Lin

Zheng

Mai

et al. 2021

Aging

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The occurrence of portal vein tumor thrombus (PVTT) is strongly correlated to the staging and poor prognosis of hepatocellular carcinoma (HCC) patients. However, the mechanisms of PVTT formation remain unclear. This study aimed to investigate differentially expressed genes (DEGs) between primary tumor (PT) and PVTT tissues and comprehensively explored the underlying mechanisms of PVTT formation. The DEGs between PT and paired PVTT tissues were analyzed using transcriptional data from the Gene Expression Omnibus (GEO) database. The expression, clinical relevance, prognostic significance, genetic alternations, DNA methylation, correlations with immune infiltration, co-expression correlations, and functional enrichment analysis of the DEGs were explored using multiple databases. As result, 12 DEGs were commonly down-expressed in PVTT compared with PT tissues among three datasets. The expression of DCN , CCL21 , IGJ , CXCL14 , FCN3 , LAMA2 , and NPY1R was progressively decreased from normal liver, PT, to PVTT tissues, whose up-expression associated with favorable survivals of HCC patients. The genetic alternations and DNA methylation of the DEGs frequently occurred, and several methylated CpG sites of the DEGs significantly correlated with outcomes of HCC patients. The immune infiltration in the tumor microenvironment of HCC was correlated with the expression level of the DEGs. Besides, the DEGs and their co-expressive genes participated in the biological processes of extracellular matrix (ECM) organization and focal adhesion. In summary, this study indicated the dysregulation of ECM and focal adhesion might contribute to the formation of PVTT. And the above seven genes might serve as potential biomarkers of PVTT occurrence and prognosis of HCC patients.

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Section: Discussionmentioning

confidence: 99%

Identification of prognostic biomarkers associated with the occurrence of portal vein tumor thrombus in hepatocellular carcinoma

Lin

Zheng

Mai

et al. 2021

Aging

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“…After performing an ileal anastomosis, those authors found hydroxyproline concentration was increased in CV but not in GF rats, where it was even reduced. One may hypothesize that metabolic and signaling products of the bacteria were able to influence fibroblasts in the colon mucosa, which are the main source of collagen fibers (Hooper et al 2012Narayanan et al 1989Wang et al 2019;Jurgensen et al 2020). Bacteria and their strain can differently affect the intestinal fibrosis process and fibroblast activation as shown by Jacob et al (2018) in an experimental model where stool from mice with defined microflora was transplanted into GF mice.…”

Section: Discussionmentioning

confidence: 99%

Immune activation by microbiome shapes the colon mucosa: Comparison between healthy rat mucosa under conventional and germ-free conditions

Čaja

Stakheev

Chernyavskiy

et al. 2021

Journal of Immunotoxicology

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Germ-free animals (GF) are those without a microbiome since birth. This particular biological model has become one of special interest with the growing evidence of importance of the microbiome in the life, development, adaptation, and immunity of humans and animals in the environments in which they live. Anatomical differences observed in GF compared with conventionally-reared animals (CV) has given rise to the question of the influence of commensal microflora on the development of structure and function (even immunological) of the bowel. Only recently, thanks to achievements in microscopy and associated methods, structural differences can be better evaluated and put in perspective with the immunological characteristics of GF vs. CV animals. This study, using a GF rat model, describes for the first time the possible influence that the presence of commensal microflora, continuously stimulating mucosal immunity, has on the collagen scaffold organization of the colon mucosa. Significant differences were found between CV and GF mucosa structure with higher complexity in the CV rats associated to a more activated immune environment. The immunological data suggest that, in response to the presence of a microbiome, an effective homeostatic regulation in developed by the CV rats in healthy conditions to avoid inflammation and maintain cytokine levels near the spontaneous production found in the GF animals. The results indicated that collagen scaffold adapted to the immune microenvironment; therefore, it is apparent that the microbiome was able to condition the structure of the colon mucosa.

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“…It is an important part of extracellular matrix, and plays a regulatory role in tissue structure. Its subunits directly affect cell phenotypes by mediating cell differentiation and apoptosis via relevant signaling pathways (Brondijk et al, 2010;Jürgensen et al, 2020). Collagen also acts as a major part in the immune system.…”

Section: Collagen Familymentioning

confidence: 99%

Transcriptome Profiling Based on Different Time Points After Hatching Provides a Core Set of Gene Resource for Understanding Larval Immune Response Mechanisms Against Vibrio anguillarum Infection in Amphioctopus fangsiao

Bao

Zhang³

et al. 2021

Front. Mar. Sci.

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Immune defense systems are indispensable for living organisms. Within an immune network, problems with any given link can impact the normal life activities of an organism. Amphioctopus fangsiao is a cephalopod that exists widely throughout the world’s oceans. Because of its nervous system and locomotive organs, it has become increasingly studied in recent years. Vibrio anguillarum is one of the most common pathogenic bacteria in aquaculture organisms. It is highly infectious and can infect almost all aquaculture organisms. V. anguillarum infection can cause many adverse biological phenomena, including tissue bleeding. Study the immune response after V. anguillarum infection would help us to understand the molecular mechanisms of immune response in aquaculture organisms. In this research, we infected the primary incubation A. fangsiao with V. anguillarum for 24 h. We analyzed gene expression in A. fangsiao larvae via transcriptome profiles at 0, 4, 12, and 24 h after hatching, and 1,385, 734, and 6,109 differentially expressed genes (DEGs) were identified at these three time points. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were used to identify immune-related DEGs. Protein–protein interaction networks were constructed to examine interactions between immune-related genes. Twenty hub genes involved in multiple KEGG signaling pathways or with multiple protein–protein interaction relationships were identified, and their differential expression verified by quantitative RT-PCR. We first studied V. anguillarum infection of A. fangsiao larvae by means of protein–protein interaction networks. The results provide valuable genetic resources for understanding immunity in molluscan larvae. These data serve as a theoretical basis for the artificial breeding of A. fangsiao.

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Cellular uptake of collagens and implications for immune cell regulation in disease

Cited by 28 publications

References 151 publications

Identification of prognostic biomarkers associated with the occurrence of portal vein tumor thrombus in hepatocellular carcinoma

Identification of prognostic biomarkers associated with the occurrence of portal vein tumor thrombus in hepatocellular carcinoma

Immune activation by microbiome shapes the colon mucosa: Comparison between healthy rat mucosa under conventional and germ-free conditions

Transcriptome Profiling Based on Different Time Points After Hatching Provides a Core Set of Gene Resource for Understanding Larval Immune Response Mechanisms Against Vibrio anguillarum Infection in Amphioctopus fangsiao

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