Cellular Uptake and In Vitro Drug Release Studies on Paclitaxel-Loaded Poly(caprolactone)-Grafted Dextran Copolymeric Nanoparticles

Prabu, P.; Chaudhari, Atul A.; Ko, Ji Hyun; Dharmaraj, N.; Park, S. Y.; Kim, H. Y.; Khil, Myung-Seob

doi:10.1007/s12030-010-9031-7

Cited by 5 publications

(2 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The internalization of nanoparticles in Hela cells was proved by confocal laser scanning microscopy (CLSM, Olympus FV1000, Japan) according to the reference with some modification [9]. Briefly, Hela cells were seeded on Lab-Tek® chambered cover glasses and incubated until cells were about 80% confluent.…”

Section: Nanoparticle Uptake By Hela Cellsmentioning

confidence: 99%

Cellular Uptake of PEGylated PLGA Nanoparticles in Hela Cells

Lin

Xie

et al. 2012

AMR

View full text Add to dashboard Cite

PLGA nanoparticles (PLGA-NPs) are being extensively studied as drug carriers for their controlled release, biodegradability and biocompatibility. This study evaluated the cellular uptake of PEGylated PLGA-NPs in Hela cells. MePEG-PLGA (5%-15%) was used to prepare PEG modified PLGA nanoparticles (PEG-PLGA-NPs), and the fluorescent marker DiI was encapsulated in the nanoparticles for the visualized analysis. The nanoparticles were characterized for surface morphology, particle size, zeta potential, and for cellular uptake by Hela cells. Results showed that PLGA nanoparticles were lowly cytotoxic and could be uptaken by Hela cells freely. PEG-PLGA-NPs had faster cellular uptake than that of nude PLGA nanoparticles, especially 10%PEG-PLGA-NPs. It suggested that the surface modification of PLGA-NPs by PEG notably improved the cellular uptake.

show abstract

Section: Nanoparticle Uptake By Hela Cellsmentioning

confidence: 99%

Cellular Uptake of PEGylated PLGA Nanoparticles in Hela Cells

Lin

Xie

et al. 2012

AMR

View full text Add to dashboard Cite

show abstract

“…18,19 Interestingly, CS has been shown to target breast cancer stem-like cells overexpressing CD44 receptors. 20 Polymer conjugates and NPs have been employed as drug carriers to improve the solubility, stability, drug retention, and to reduce the adverse effect of taxanes, 21,22 and paclitaxelloaded polymeric NPs (Genexol) have been approved for treatment of various cancers. 23 Although current drugpolymeric micellar NPs improve drug solubility and decrease drug toxicity, their therapeutic efficacy is often comparable to that of free drug.…”

Section: Introductionmentioning

confidence: 99%

Drug-Loaded Photosensitizer-Chitosan Nanoparticles for Combinatorial Chemo- and Photodynamic-Therapy of Cancer

et al. 2020

View full text Add to dashboard Cite

In this study we have developed biodegradable polymeric nanoparticles (NPs) containing the cytostatic drugs mertansine (MRT) or cabazitaxel (CBZ). The NPs are based on chitosan (CS) conjugate polymers synthesized with different amounts of the photosensitizer tetraphenylchlorin (TPC). These TPC−CS NPs have high loading capacity and strong drug retention due to π−π stacking interactions between the drugs and the aromatic photosensitizer groups of the polymers. CS polymers with 10% of the side chains containing TPC were found to be optimal in terms of drug loading capacity and NP stability. The TPC−CS NPs loaded with MRT or CBZ displayed higher cytotoxicity than the free form of these drugs in the breast cancer cell lines MDA-MB-231 and MDA-MB-468. Furthermore, light-induced photochemical activation of the NPs elicited a strong photodynamic therapy effect on these breast cancer cells. Biodistribution studies in mice showed that most of the TPC−CS NPs accumulated in liver and lungs, but they were also found to be localized in tumors derived from HCT-116 cells. These data suggest that the drug-loaded TPC−CS NPs have a potential in combinatory anticancer therapy and as contrast agents.

show abstract

Preparation and Evaluation of MPEG-PCL Polymeric Nanoparticles Against Gastric Cancer

Liu

Huang

et al. 2020

J. Wuhan Univ. Technol.-Mat. Sci. Edit.

View full text Add to dashboard Cite

Cellular Uptake and In Vitro Drug Release Studies on Paclitaxel-Loaded Poly(caprolactone)-Grafted Dextran Copolymeric Nanoparticles

Cited by 5 publications

References 33 publications

Cellular Uptake of PEGylated PLGA Nanoparticles in Hela Cells

Cellular Uptake of PEGylated PLGA Nanoparticles in Hela Cells

Drug-Loaded Photosensitizer-Chitosan Nanoparticles for Combinatorial Chemo- and Photodynamic-Therapy of Cancer

Preparation and Evaluation of MPEG-PCL Polymeric Nanoparticles Against Gastric Cancer

Contact Info

Product

Resources

About