Cellular uptake and cytotoxicity of PEGylated MXene nanomaterials mediated by protein corona

Wu, Xuri; Gong, Jixiang; Zhang, Han; Wang, Yan; Tan, Feng

doi:10.1016/j.scitotenv.2023.169227

Cited by 5 publications

(5 citation statements)

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“…While MXene did not significantly affect cell viability, it exhibited a dual role as both a stimulus and scavenger of reactive oxygen species (ROS) within THP-1 cells, influenced by PEGylation and protein corona formation. 150 The therapeutic potential of MoS 2 QDs/MM, incorporating macrophage membrane targeting and NIR therapy, was investigated for multitarget therapy in Alzheimer's disease. Results demonstrated targeted ROS elimination and reduction in Aβ1−42 deposition, effectively mitigating cytotoxicity.…”

Section: Healthcare Applicationsmentioning

confidence: 99%

“…Both MXene and PEGylated MXene accumulated in lysosomal sites within THP-1 cells, primarily through clathrin-mediated endocytosis. While MXene did not significantly affect cell viability, it exhibited a dual role as both a stimulus and scavenger of reactive oxygen species (ROS) within THP-1 cells, influenced by PEGylation and protein corona formation . The therapeutic potential of MoS 2 QDs/MM, incorporating macrophage membrane targeting and NIR therapy, was investigated for multitarget therapy in Alzheimer’s disease.…”

Section: Properties Of 2d Nanomaterials Used In Healthcare Applicationsmentioning

confidence: 99%

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Recent Advances in Two-Dimensional Nanomaterials for Healthcare Monitoring

Manoharan,

Batcha,

Mahalingam

et al. 2024

ACS Sens.

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The development of advanced technologies for the fabrication of functional nanomaterials, nanostructures, and devices has facilitated the development of biosensors for analyses. Two-dimensional (2D) nanomaterials, with unique hierarchical structures, a high surface area, and the ability to be functionalized for target detection at the surface, exhibit high potential for biosensing applications. The electronic properties, mechanical flexibility, and optical, electrochemical, and physical properties of 2D nanomaterials can be easily modulated, enabling the construction of biosensing platforms for the detection of various analytes with targeted recognition, sensitivity, and selectivity. This review provides an overview of the recent advances in 2D nanomaterials and nanostructures used for biosensor and wearable-sensor development for healthcare and healthmonitoring applications. Finally, the advantages of 2D-nanomaterial-based devices and several challenges in their optimal operation have been discussed to facilitate the development of smart highperformance biosensors in the future.

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Section: Healthcare Applicationsmentioning

confidence: 99%

Section: Properties Of 2d Nanomaterials Used In Healthcare Applicationsmentioning

confidence: 99%

Recent Advances in Two-Dimensional Nanomaterials for Healthcare Monitoring

Manoharan,

Batcha,

Mahalingam

et al. 2024

ACS Sens.

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Section: How Can We Exploit This Alliance?mentioning

confidence: 99%

“…This includes processes like cellular internalization and pathway activation, which may be notably affected [64]. Wu et al [65] explored the cellular internalization and toxic impact of MXene Ti3C2Tx and polyethylene glycol (PEG)-modified Ti3C2Tx in THP-1 cells, mediated by the presence of a human serum protein corona (Figure 4). They presented the possibility that the PEGylation process could change the interactions between Ti3C2Tx and serum proteins and thus cause a major transformation in the PC fingerprint.…”

Section: How Can We Exploit This Alliance?mentioning

confidence: 99%

“…They reported that no significant effect on cell viability was observed. In addition, Ti3C2Tx has a dual effect as both a stimulator and scavenger of ROS in THP-1 cells, which are affected by PEGylation and PC formation [65]. The cellular destiny of the nanocarriers is influenced by alterations in the composition of the PC, which can be contingent upon certain parameters.…”

Section: How Can We Exploit This Alliance?mentioning

confidence: 99%

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A Review for Uncovering the “Protein-Nanoparticle Alliance”: Implications of the Protein Corona for Biomedical Applications

Önal Acet,

Gül,

Stauber

et al. 2024

Nanomaterials

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Understanding both the physicochemical and biological interactions of nanoparticles is mandatory for the biomedical application of nanomaterials. By binding proteins, nanoparticles acquire new surface identities in biological fluids, the protein corona. Various studies have revealed the dynamic structure and nano–bio interactions of the protein corona. The binding of proteins not only imparts new surface identities to nanoparticles in biological fluids but also significantly influences their bioactivity, stability, and targeting specificity. Interestingly, recent endeavors have been undertaken to harness the potential of the protein corona instead of evading its presence. Exploitation of this ‘protein–nanoparticle alliance’ has significant potential to change the field of nanomedicine. Here, we present a thorough examination of the latest research on protein corona, encompassing its formation, dynamics, recent developments, and diverse bioapplications. Furthermore, we also aim to explore the interactions at the nano–bio interface, paving the way for innovative strategies to advance the application potential of the protein corona. By addressing challenges and promises in controlling protein corona formation, this review provides insights into the evolving landscape of the ‘protein–nanoparticle alliance’ and highlights emerging.

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