Cellular tumorigenicity in nude mice: Correlation with cell growth in semi-solid medium

The metastatic cancer cell cortex: An adaptation to enhance robust cell division in novel environments?

“…This is based on the strong correlation between a cell's ability to proliferate and form colonies in semi-solid media and its potential to induce metastatic tumors following injection into mice [2]. Most non-transformed cells rely on constant adhesionbased signaling for their continued survival and proliferation, both through cell-cell contacts and through integrinmediated adhesion to the extra-cellular matrix (ECM).…”

Chemical transformation of Chinese hamster cells. I. A comparison of some properties of transformed cells

“…However, good agreement has been reported between tumourigenicity and growth in soft agar (Kirkland and Pick, 1973;Kirkland et al, 1975;Evans and DiPaolo, 1975) or in a comparable methyl cellulose suspension medium (Freedman and Shin, 1974). It would therefore seem justifiable, for the present, to take growth in soft agar as one indicator of malignancy.…”

The efficiency of tumor cell purging using immunomagnetic CD34+ cell separation systems

“…29,30 In consequence, Experiments Nos 5 and 6 are examples for a tumor cell line (HTB 131) in which still unknown reasons produce HTCA results may bear higher predictability for a potential relapse of the disease. a much lower purging effect than expected.…”