Cellular/tissue engineering-promises and challenges in tissue engineering

Papadaki, M.

doi:10.1109/51.956007

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The Promises Of Tissue Engineering1

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“…Significant effort and progress have been made in TE in the past 20 years and the pronounced milestones include development of biodegradable scaffolds, TE constructs comprised of cells and biomaterials and bioreactors [14]. The advances in TE have stimulated and led to great success in clinical applications.…”

Section: The Promises Of Tissue Engineeringmentioning

confidence: 99%

Introduction to Tissue Engineering

Chua¹,

Yeong²

2014

Bioprinting

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Section: The Promises Of Tissue Engineeringmentioning

confidence: 99%

Introduction to Tissue Engineering

Chua¹,

Yeong²

2014

Bioprinting

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Heart Valve Tissue Engineering

Veselý

2005

Circulation Research

276

144

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Abstract-Tissue-engineered heart valves have been proposed by physicians and scientists alike to be the ultimate solution for treating valvular heart disease. Rather than replacing a diseased or defective native valve with a mechanical or animal tissue-derived artificial valve, a tissue-engineered valve would be a living organ, able to respond to growth and physiological forces in the same way that the native aortic valve does. Two main approaches have been attempted over the past 10 to 15 years: regeneration and repopulation. Regeneration involves the implantation of a resorbable matrix that is expected to remodel in vivo and yield a functional valve composed of the cells and connective tissue proteins of the patient. Repopulation involves implanting a whole porcine aortic valve that has been previously cleaned of all pig cells, leaving an intact, mechanically sound connective tissue matrix. The cells of the patients are expected to repopulate and revitalize the acellular matrix, creating living tissue that already has the complex microstructure necessary for proper function and durability. Regrettably, neither of the 2 approaches has fared well in animal experiments, and the only clinical experience with tissue-engineered valves resulted in a number of early failures and patient death. This article reviews the technological details of the 2 main approaches, their rationale, their strengths and weaknesses, and the likely mechanisms for their failure. Alternative approaches to valvular tissue engineering, as well as the role of industry in shaping this field in the future, are also reviewed.

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Cellular/tissue engineering-promises and challenges in tissue engineering

Cited by 2 publications

References 8 publications

Introduction to Tissue Engineering

Introduction to Tissue Engineering

Heart Valve Tissue Engineering

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