Cellular therapy for sickle cell disease

Abraham, Allistair; Jacobsohn, David A.; Bollard, Catherine M.

doi:10.1016/j.jcyt.2016.06.011

Cited by 11 publications

(7 citation statements)

References 66 publications

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“…Sickle cell anemia is one of the most common monogenic red cell disorders worldwide. It is a multi-system disorder, associated with episodes of acute illness, progressive organ damage and premature death [1,2]. Although all homozygous sickle cell disease patients have the same genetic alteration in their DNA, they experience a wide spectrum of clinical manifestations, ranging from an almost asymptomatic condition to severe illness.…”

Section: Introductionmentioning

confidence: 99%

The effect of interleukin-1β and interleukin-6 genetic polymorphisms on sickle cell disease course in childhood: an Egyptian study

Khorshied¹,

Ibrahim²,

Gad³

et al. 2018

Arch Med Sci Civil Dis

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Introduction: Sickle cell disease (SCD) is a chronic inflammatory disorder characterized by altered levels of several inflammatory cytokines, which may be regulated by genetic polymorphisms and could be associated with diverse clinical presentations. Interleukin 1β (IL-1) and interleukin 6 (IL-6) have a pivotal role in the pathogenesis of many acute and chronic diseases, and their genetic alterations have been considered as molecular contributors to several inflammatory disorders. The current study aimed to define the impact of IL-1β and IL-6 genetic polymorphisms on the clinical course of the disease in a cohort of pediatric SCD patients. Material and methods: Genotyping of IL-1β +3954 C/T and IL-6-174 G/C polymorphisms was performed by the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) technique for 84 SCD patients and 100 age-and gender-matched unrelated healthy controls. Results: The polymorphic genotypes of IL-6-174 G/C were associated with patients suffering from repeated, severe attacks of vaso-occlusion (VOC) requiring hospitalization (p = 0.023 and p = 0.03 respectively), while no significant differences were noted between SCD patients harboring the wild or the polymorphic genotypes of IL-1β +3954 C/T and their demographic, clinical or laboratory characteristics. Conclusions: IL-6-174 G/C polymorphism could be considered as a molecular predictor for recurrent, severe attacks of vascular occlusion in Egyptian SCD patients. Considering the important roles of cytokines in SCD pathophysiology, further investigations in larger cohorts are recommended for better characterization of individual variations in immune regulatory genes and identification of novel markers for disease complications and morbidity.

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Section: Introductionmentioning

confidence: 99%

The effect of interleukin-1β and interleukin-6 genetic polymorphisms on sickle cell disease course in childhood: an Egyptian study

Khorshied¹,

Ibrahim²,

Gad³

et al. 2018

Arch Med Sci Civil Dis

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“…SCD is one of the most common autosomal recessive blood hereditary diseases, affecting approximately 300,000 newborns every year (Abraham et al, 2016). Single nucleotide mutation in the Hb β-chain coding gene is responsible for the molecular mechanism of this disease occurrence (Dever et al, 2016;Kato et al, 2018).…”

Section: Sickle Cell Disease-and Hemophilia-associated Osteoarthritismentioning

confidence: 99%

Interplay Between Iron Overload and Osteoarthritis: Clinical Significance and Cellular Mechanisms

Cai

Chu

2022

Front. Cell Dev. Biol.

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There are multiple diseases or conditions such as hereditary hemochromatosis, hemophilia, thalassemia, sickle cell disease, aging, and estrogen deficiency that can cause iron overload in the human body. These diseases or conditions are frequently associated with osteoarthritic phenotypes, such as progressive cartilage degradation, alterations in the microarchitecture and biomechanics of the subchondral bone, persistent joint inflammation, proliferative synovitis, and synovial pannus. Growing evidences suggest that the conditions of pathological iron overload are associated with these osteoarthritic phenotypes. Osteoarthritis (OA) is an important complication in patients suffering from iron overload-related diseases and conditions. This review aims to summarize the findings and observations made in the field of iron overload-related OA while conducting clinical and basic research works. OA is a whole-joint disease that affects the articular cartilage lining surfaces of bones, subchondral bones, and synovial tissues in the joint cavity. Chondrocytes, osteoclasts, osteoblasts, and synovial-derived cells are involved in the disease. In this review, we will elucidate the cellular and molecular mechanisms associated with iron overload and the negative influence that iron overload has on joint homeostasis. The promising value of interrupting the pathologic effects of iron overload is also well discussed for the development of improved therapeutics that can be used in the field of OA.

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“…They subsequently classified 14 viruses as belonging to the Bunyamwera group viruses and further identified five subgroups or complexes: Bunyamwera, Cache Valley, Wyeomyia, Kairi, and Guaroa ( 43 ). In 1978, this classification was updated based on the antigenic relationships of Bunyamwera group viruses established by the cross-neutralization pattern of virus-specific hyperimmune antibodies ( 44 , 45 ). From this effort emerged three subgroups that diverge largely over geographic origin: South America, Africa, and Europe/Asia (of which BATV is the only member) ( 28 ).…”

Section: Classification Genomic Characteristics and Replication In mentioning

confidence: 99%

A Review of Bunyamwera, Batai, and Ngari Viruses: Understudied Orthobunyaviruses With Potential One Health Implications

Dutuze

Nzayirambaho

et al. 2018

Front. Vet. Sci.

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Bunyamwera (BUNV), Batai (BATV), and Ngari (NRIV) are mosquito-borne viruses of the Bunyamwera serogroup in the Orthobunyavirus genus of the Bunyaviridae family. These three viruses have been found to cause disease in both livestock animals, avian species, and humans. Thus, these viruses pose a potential threat to human public health, animal health, and food security. This is especially the case in the developing nations, where BUNV and NRIV are found, mainly in Africa. BUNV and BATV are fairly well characterized, while NRIV is not well characterized owing to only sporadic detection in human and animal populations in Africa. Reassortment is common among bunyaviruses, but NRIV is believed to be the only natural reassortant of the Bunyamwera serogroup. It resulted from a combination of BUNV S and L segments and the BATV M segment. This indicates at least some level co-circulation of BUNV and BATV, which have no historically been reported to overlap in geographic distributions. But as these viruses are undercharacterized, there remains a gap in the understanding of how such reassortment could occur, and the consequences of such. Due to their combined wide range of hosts and vectors, geographic distributions, potential severity of associated diseases, and potential for transmissibility between vertebrate hosts, these viruses represent a significant gap in knowledge with important One Health implications. The goal of this review is to report available knowledge of and identify potential future directions for study of these viruses. As these are collectively understudied viruses, there is a relative paucity of data; however, we use available studies to discuss different perspectives in an effort to promote a better understanding of these three viruses and the public and One Health threat(s) they may pose.

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Cellular therapy for sickle cell disease

Cited by 11 publications

References 66 publications

The effect of interleukin-1β and interleukin-6 genetic polymorphisms on sickle cell disease course in childhood: an Egyptian study

The effect of interleukin-1β and interleukin-6 genetic polymorphisms on sickle cell disease course in childhood: an Egyptian study

Interplay Between Iron Overload and Osteoarthritis: Clinical Significance and Cellular Mechanisms

A Review of Bunyamwera, Batai, and Ngari Viruses: Understudied Orthobunyaviruses With Potential One Health Implications

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