Cellular-Telephone Use and Brain Tumors

Inskip, Peter D.; Tarone, Robert E.; Hatch, Elizabeth E.; Wilcosky, Timothy; Shapiro, William R.; Selker, Robert G.; Fine, Howard A.; Black, Peter M.; Loeffler, Jay S.; Linet, Martha S.

doi:10.1056/nejm200101113440201

Cited by 416 publications

(291 citation statements)

References 30 publications

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“…To date, several case -control studies have been reported from the United States (Muscat et al, 2000;Inskip et al, 2001), Finland (Auvinen et al, 2002), and Sweden (Hardell et al, 1999(Hardell et al, , 2002(Hardell et al, , 2003(Hardell et al, , 2004 before the INTERPHONE study. Two US studies showed negative results for the overall risk of brain tumours, whereas in a Finnish population register-based study, the OR for glioma with relation to ever use of analogue mobile phones was 2.1 (95% CI: 1.3 -3.4).…”

Section: Discussionmentioning

confidence: 99%

Mobile phone use, exposure to radiofrequency electromagnetic field, and brain tumour: a case–control study

et al. 2008

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In a case -control study in Japan of brain tumours in relation to mobile phone use, we used a novel approach for estimating the specific absorption rate (SAR) inside the tumour, taking account of spatial relationships between tumour localisation and intracranial radiofrequency distribution. Personal interviews were carried out with 88 patients with glioma, 132 with meningioma, and 102 with pituitary adenoma (322 cases in total), and with 683 individually matched controls. All maximal SAR values were below 0.1 W kg À1 , far lower than the level at which thermal effects may occur, the adjusted odds ratios (ORs) for regular mobile phone users being 1.22 (95% confidence interval (CI): 0.63 -2.37) for glioma and 0.70 (0.42 -1.16) for meningioma. When the maximal SAR value inside the tumour tissue was accounted for in the exposure indices, the overall OR was again not increased and there was no significant trend towards an increasing OR in relation to SAR-derived exposure indices. A non-significant increase in OR among glioma patients in the heavily exposed group may reflect recall bias. British Journal of Cancer (2008) The rapid increase in mobile phone use has raised public concern about their safety (Rothman et

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Section: Discussionmentioning

confidence: 99%

Mobile phone use, exposure to radiofrequency electromagnetic field, and brain tumour: a case–control study

et al. 2008

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“…5,16 There is no evidence supporting the influence of mobile phone use on the occurrence of benign or malignant CNS tumors, especially those located in the temporal lobe. 17,18,24 Results of studies on mobile phone handset radiation and the risk of developing acoustic neuroma have been contradictory (Table 1). Some authors have found no increased probability of tumor development in mobile phone users, 18,19,21,24 while other have stated that the use of mobile phones -particularly analog handsets -for 10 years or more is a risk factor for developing tumors.…”

Section: Discussionmentioning

confidence: 99%

“…17,18,24 Results of studies on mobile phone handset radiation and the risk of developing acoustic neuroma have been contradictory (Table 1). Some authors have found no increased probability of tumor development in mobile phone users, 18,19,21,24 while other have stated that the use of mobile phones -particularly analog handsets -for 10 years or more is a risk factor for developing tumors. 7,20,23 Muscat et al (2002) 19 have pointed out that acoustic neuromas are slow-growing tumors, and may have been present in case-control study subjects before they began to use mobile phones.…”

Section: Discussionmentioning

confidence: 99%

“…A further point is that cranial nerve tumors are rare, and the neuroma cases that were studied were part of small series. 7,[18][19][20][21]23,24 Various papers have suggested that exposure to mobile phone microwaves has no influence on the activity of cochlear outer hair cells or of cochlear nerve electrical conduction, both in vivo and in vitro. 8,11,15,25,26 Another point is that all of the studies on humans were carried out on normal-hearing volunteers.…”

Section: Discussionmentioning

confidence: 99%

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Telefones celulares: influência nos sistemas auditivo e vestibular

Balbani

Montovani

2008

Rev. Bras. Otorrinolaringol.

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Tel ecommunications systems emit radiofrequency, which is an invisible electromagnetic radiation. Mobile phones operate with microwaves (450900 MHz in the analog service, and 1,82,2 GHz in the digital service) very close to the user's ear. The skin, inner ear, cochlear nerve and the temporal lobe surface absorb the radiofrequency energy. Aim: literature review on the influence of cellular phones on hearing and balance. Study design: systematic review. Methods: We reviewed papers on the influence of mobile phones on auditory and vestibular systems from Lilacs and Medline databases, published from 2000 to 2005, and also materials available in the Internet. Results: Studies concerning mobile phone radiation and risk of developing an acoustic neuroma have controversial results. Some authors did not see evidences of a higher risk of tumor development in mobile phone users, while others report that usage of analog cellular phones for ten or more years increase the risk of developing the tumor. Acute exposure to mobile phone microwaves do not influence the cochlear outer hair cells function in vivo and in vitro, the cochlear nerve electrical properties nor the vestibular system physiology in humans. Analog hearing aids are more susceptible to the electromagnetic interference caused by digital mobile phones. Conclusion: there is no evidence of cochleo-vestibular lesion caused by cellular phones

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“…Recent studies have failed to reveal a link between brain cancer and use of cellular telephones (Muscat et al, 2000;Inskip et al, 2001;Johansen et al, 2001), although there were limitations in terms of the duration of phone use and length of follow-up. A recently published case -control interview study from Germany reported a significant four-fold increased risk of malignant melanoma of the eye associated with the use of radiofrequency (RF) transmitting devices, including mobile telephones (Stang et al, 2001).…”

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confidence: 99%

Mobile phones and malignant melanoma of the eye

Johansen

Boice

et al. 2002

Br J Cancer

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Recently a four-fold increase in the risk of malignant melanoma of the eye was associated with the use of radiofrequency transmitting devices, including mobile phones in Germany. We contrasted the incidence rates of this rare cancer with the number of mobile phone subscribers in Denmark. We observed no increasing trend in the incidence rate of melanoma, which was in sharp contrast to the exponentially increasing number of mobile phone subscribers starting in the early 1980s. Our study provides no support for an association between mobile phones and ocular melanoma.

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Cellular-Telephone Use and Brain Tumors

Abstract: These data do not support the hypothesis that the recent use of hand-held cellular telephones causes brain tumors, but they are not sufficient to evaluate the risks among long-term, heavy users and for potentially long induction periods.

Cited by 416 publications

References 30 publications

Mobile phone use, exposure to radiofrequency electromagnetic field, and brain tumour: a case–control study

Mobile phone use, exposure to radiofrequency electromagnetic field, and brain tumour: a case–control study

Telefones celulares: influência nos sistemas auditivo e vestibular

Mobile phones and malignant melanoma of the eye

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