Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis

Barati, Mojdeh; Darvishi, Behrad; Javidi, Maryam; Mohammadian, Ali; Shariatpanahi, Seyed Peyman; Eisavand, Mohammad Reza; Ansari, Alireza Madjid

doi:10.1111/cpr.13154

Cited by 28 publications

(35 citation statements)

References 213 publications

(275 reference statements)

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“…Many studies report that non-ionizing, non-thermal, extremely low-frequency EMF can modulate apoptosis. However, the results of other studies differ and there is an opinion that statistically significant changes in apoptosis are not observed 49 . However, they did not observe a statistically significant difference in the study by Martinelli et al, when exposed to EMF (915 MHz) on cardiac cells, their structural tissue integrity, and the expression of apoptotic genes 50 .…”

Section: Discussionmentioning

confidence: 85%

Comparison of pulsed and continuous electromagnetic field generated by WPT system on human dermal and neural cells

Zahumenska,

Badurova,

Pavelek

et al. 2024

Sci Rep

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In recent decades, we have seen significant technical progress in the modern world, leading to the widespread use of telecommunications systems, electrical appliances, and wireless technologies. These devices generate electromagnetic radiation (EMR) and electromagnetic fields (EMF) most often in the extremely low frequency or radio-frequency range. Therefore, they were included in the group of environmental risk factors that affect the human body and health on a daily basis. In this study, we tested the effect of exposure EMF generated by a new prototype wireless charging system on four human cell lines (normal cell lines—HDFa, NHA; tumor cell lines—SH-SY5Y, T98G). We tested different operating parameters of the wireless power transfer (WPT) device (87–207 kHz, 1.01–1.05 kW, 1.3–1.7 mT) at different exposure times (pulsed 6 × 10 min; continuous 1 × 60 min). We observed the effect of EMF on cell morphology and cytoskeletal changes, cell viability and mitotic activity, cytotoxicity, genotoxicity, and oxidative stress. The results of our study did not show any negative effect of the generated EMF on either normal cells or tumor cell lines. However, in order to be able to estimate the risk, further population and epidemiological studies are needed, which would reveal the clinical consequences of EMF impact.

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Section: Discussionmentioning

confidence: 85%

Comparison of pulsed and continuous electromagnetic field generated by WPT system on human dermal and neural cells

Zahumenska,

Badurova,

Pavelek

et al. 2024

Sci Rep

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“…The diagram (Fig. 14 ) showed that how the ELF-EMF might activate downstream signaling pathways and cellular responses (e.g., apoptosis, autophagy 61 , morphology change, differentiation) through oxidative damage.…”

Section: Discussionmentioning

confidence: 99%

Differential biological responses of adherent and non-adherent (cancer and non-cancerous) cells to variable extremely low frequency magnetic fields

Nezamtaheri

Goliaei

Shariatpanahi

et al. 2022

Sci Rep

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Extremely low-frequency electromagnetic field (ELF-EMF) induces biological effects on different cells through various signaling pathways. To study the impact of the ELF-EMF on living cells under an optimal physiological condition, we have designed and constructed a novel system that eliminates several limitations of other ELF-EMF systems. Apoptosis and cell number were assessed by flow cytometry and the Trypan Blue dye exclusion method, respectively. In vitro cell survival was evaluated by colony formation assay. The distribution of cells in the cell cycle, intracellular ROS level, and autophagy were analyzed by flow cytometer. Suspended cells differentiation was assessed by phagocytosis of latex particles and NBT reduction assay. Our results showed that response to the exposure to ELF-EMF is specific and depends on the biological state of the cell. For DU145, HUVEC, and K562 cell lines the optimum results were obtained at the frequency of 0.01 Hz, while for MDA-MB-231, the optimum response was obtained at 1 Hz. Long-term exposure to ELF-EMF in adherent cells effectively inhibited proliferation by arresting the cell population at the cell cycle G2/M phase and increased intracellular ROS level, leading to morphological changes and cell death. The K562 cells exposed to the ELF-EMF differentiate via induction of autophagy and decreasing the cell number. Our novel ELF-EMF instrument could change morphological and cell behaviors, including proliferation, differentiation, and cell death.

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“…In recent years the cellular responses mobilized by PEMF exposure have come into clearer focus and commonly impinge upon calcium signaling and mitochondrial respiration (ROS) to reach fruition [14,20,[48][49][50][51][52][53]. One calcium-permeable channel in particular, the Transient Receptor Potential Cation Channel Subfamily C Member 1, or TRPC1, has received attention [20,22,23,27,28,52,54,55].…”

Section: Muscle-targeted Pemf Therapy and Metabolic Stabilizationmentioning

confidence: 99%

Brief, weekly magnetic muscle therapy improves mobility and lean body mass in older adults: a Southeast Asia community case study

Venugobal

Tai

Goh

et al. 2023

Aging

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Brief (10 min) weekly exposure to low energy pulsed electromagnetic fields (PEMFs) has been shown to improve human muscle mitochondrial bioenergetics and attenuate systemic lipotoxicity following anterior cruciate ligament surgical reconstruction. Here we present data generated from 101 participants, 62% female, aged 38-91 years, recruited from the QuantumTx Demo Centre in Singapore, wherein 87% of participants (n = 88) presented with pre-existing mobility dysfunction and 13% (n = 13) were healthy volunteers. Participants were recruited if: (i) not pregnant; (ii) above 35 years of age and; (iii) without surgical implants. All participants completed mobility testing, pre-and post-PEMF intervention for 12 weeks, whereas bioelectrical impedance analysis was conducted in a subgroup of 42 and 33 participants at weeks 4 and 8, respectively.Weekly PEMF exposure was associated with significant improvements in mobility (Timed Up and Go, 5 times Sit-to-Stand, and 4m Normal Gait Speed) and body composition (increased skeletal muscle mass and reduced total and visceral fat mass), particularly in the older participants. Perception of pain was also significantly reduced. PEMF therapy may provide a manner to counteract age-associated mobility and metabolic disruptions and merits future investigation in randomized controlled trials to elucidate its clinical benefits in the frail and older adult populations.

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Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis

Cited by 28 publications

References 213 publications

Comparison of pulsed and continuous electromagnetic field generated by WPT system on human dermal and neural cells

Comparison of pulsed and continuous electromagnetic field generated by WPT system on human dermal and neural cells

Differential biological responses of adherent and non-adherent (cancer and non-cancerous) cells to variable extremely low frequency magnetic fields

Brief, weekly magnetic muscle therapy improves mobility and lean body mass in older adults: a Southeast Asia community case study

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