Cellular Stress, Energy Constraints and the Energy Allocation Hypothesis of Sleep
Markus H. Schmidt,
Kaspar A. Schindler
Abstract:A growing body of literature demonstrates a critical role for sleep in upregulating diverse biological processes related to protein synthesis, immune function, and cellular housekeeping such as intracellular transport and membrane repair. The energy allocation (EA) hypothesis places sleep in a broader context of resource optimization where sleep–wake partitioning of metabolic operations optimizes resource utilization. The EA hypothesis of sleep carries important implications in health, disease, and homeostatic… Show more
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