1978
DOI: 10.1056/nejm197808172990703
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Cellular Sensitivity to Collagen in Rheumatoid Arthritis

Abstract: We examined patients with rheumatoid arthritis for cellular sansitivity to native human Types I, II and III collagens. Mononuclear cells from 50 patients with rheumatoid arthritis, 21 with other inflammatory arthritides, 20 with osteoarthritis and 20 normal subjects were evaluated for the in vitro production of leukocyte inhibitory factor in response to collagen and a control antigen, streptokinase-streptodornase. By this assay, cells from 37 (74 per cent) and 39 (78 per cent) of the patients with rheumatoid a… Show more

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Cited by 204 publications
(75 citation statements)
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“…These studies also confirm the findings of Trentham et a1 (5,18) and Clague et a1 (15) that the titer of anticollagen antibodies correlates neither with disease activity nor with rheumatoid factor. We found no correlation between antibody titer and disease activity, age, or medications.…”
Section: Discussionsupporting
confidence: 88%
See 1 more Smart Citation
“…These studies also confirm the findings of Trentham et a1 (5,18) and Clague et a1 (15) that the titer of anticollagen antibodies correlates neither with disease activity nor with rheumatoid factor. We found no correlation between antibody titer and disease activity, age, or medications.…”
Section: Discussionsupporting
confidence: 88%
“…The mean titer of antibodies to native human type I1 collagen among the 5 HLA-DR3 positive individuals studied was 1,428 2 908 (mean ? SEM) versus 60 5 22 in individuals whose tissue type did not have HLA-DR3 (T = 1.48, P = 0.11). Although the difference did not reach statistical significance, probably due to the small number of individuals with HLA-DR3 in this study, this result was similar to that found by Dyer et a1 (38).…”
Section: Resultsmentioning
confidence: 97%
“…There is now considerable evidence that patients with RA have autoimmunity to collagen. Cellular reactions to interstitial collagens in RA were reported by Trentham et a1 (29) and by us (30). Solinger et a1 (3 1) found this reactivity to be genetically linked to HLA-DRw4, a gene previously associated with RA (32).…”
Section: Discussionmentioning
confidence: 82%
“…The circumferences of the wrists, elbows, knees, and ankles at fixed bony landmarks were recorded with a tape measure. The degree of overall synovitis was graded as 0, 1, 2, or 3, according to a previously formulated scale (13). The time required to walk 50 feet, the duration of morning stiffness, and the number of antiinflammatory and analgesic tablets or capsules ingested daily were recorded.…”
mentioning
confidence: 99%