Cellular senescence of granulosa cells in the pathogenesis of polycystic ovary syndrome
Tsurugi Tanaka,
Yoko Urata,
Miyuki Harada
et al.
Abstract:Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age, but its pathology has not been fully characterized and the optimal treatment strategy remains unclear. Cellular senescence is a permanent state of cell-cycle arrest that can be induced by multiple stresses. Senescent cells contribute to the pathogenesis of various diseases, owing to an alteration in secretory profile, termed ‘senescence-associated secretory phenotype’ (SASP), including with respect to p… Show more
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