Cellular Senescence in Liver Cancer: How Dying Cells Become “Zombie” Enemies
Aurora Gazzillo,
Camilla Volponi,
Cristiana Soldani
et al.
Abstract:Liver cancer represents the fourth leading cause of cancer-associated death worldwide. The heterogeneity of its tumor microenvironment (TME) is a major contributing factor of metastasis, relapse, and drug resistance. Regrettably, late diagnosis makes most liver cancer patients ineligible for surgery, and the frequent failure of non-surgical therapeutic options orientates clinical research to the investigation of new drugs. In this context, cellular senescence has been recently shown to play a pivotal role in t… Show more
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